Influence of pathogenic bacteria species present in the postpartum bovine uterus on proteome profiles

Ledgard, A. M.; Smolenski, Grant; Hv, Henderson; Lee, R S F

doi:10.1071/rd13144

Cited by 18 publications

(17 citation statements)

References 53 publications

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“…In cattle, XBP1 is involved in corpus luteum development and maintenance [53], and is upregulated in large follicles [54]. Window 18-19Mb of BTA26 harbors FRAT1 which is differentially expressed during the secretory phases of the human endometrium [55], and PGAM1 related to spermatogenesis success in mice [56] whose expression was found to be increased in cows with postpartum infection caused by pathogenic bacteria [57]. …”

Section: Resultsmentioning

confidence: 99%

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

et al. 2017

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Reproductive traits are economically important for beef cattle production; however, these traits are still a bottleneck in indicine cattle since these animals typically reach puberty at older ages when compared to taurine breeds. In addition, reproductive traits are complex phenotypes, i.e., they are controlled by both the environment and many small-effect genes involved in different pathways. In this study, we conducted genome-wide association study (GWAS) and functional analyses to identify important genes and pathways associated with heifer rebreeding (HR) and with the number of calvings at 53 months of age (NC53) in Nellore cows. A total of 142,878 and 244,311 phenotypes for HR and NC53, respectively, and 2,925 animals genotyped with the Illumina Bovine HD panel (Illumina®, San Diego, CA, USA) were used in GWAS applying the weighted single-step GBLUP (WssGBLUP) method. Several genes associated with reproductive events were detected in the 20 most important 1Mb windows for both traits. Significant pathways for HR and NC53 were associated with lipid metabolism and immune processes, respectively. MHC class II genes, detected on chromosome 23 (window 25-26Mb) for NC53, were significantly associated with pregnancy success of Nellore cows. These genes have been proved previously to be associated with reproductive traits such as mate choice in other breeds and species. Our results suggest that genes associated with the reproductive traits HR and NC53 may be involved in embryo development in mammalian species. Furthermore, some genes associated with mate choice may affect pregnancy success in Nellore cattle.

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Section: Resultsmentioning

confidence: 99%

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

et al. 2017

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“…and T. pyogenes were the most common. Isolation of E. coli at 0 DIM did not have an effect at 21 DIM on the isolation of T. pyogenes but T. pyogenes was associated with PVD (de-Boer et al, 2015;Ledgard et al, 2015).…”

Section: Infectious Factorsmentioning

confidence: 77%

“…Some proteins have been correlated with the percentages of PMN as well. Ledgard et al (2015) found a strong correlation between percentages of PMN and cathelicidin, PGLYRP1, SERPINB1, and S100A9. These proteins are products of immune cells in response to a current infection and during a prolonged inflammatory response.…”

Section: Diagnosis Of Uterine Diseasementioning

confidence: 78%

“…Transrectal palpation (Hartmann et al, 2016) and transrectal ultrasonography (Polat et al, 2015;Toni et al, 2015) allows to palpate or look at the reproductive organs, texture, size, and content, ultrasonography gives a more accurate diagnosis than palpation. Uterine flush (Bicalho et al, 2016), cytobrush (Madoz et al, 2014;Denis-Robichaud and Dubuc, 2015b;Ledgard et al, 2015;Pascottini et al, 2015;Polat et al, 2015;Hartmann et al, 2016), cytotape and biopsies (Hartmann et al, 2016) (Madoz et al, 2014) are more invasive methods, uterine flush consist in the introduction of fluid into the uterus to retrieve it with the uterine content sample. The cytobrush and cytotype techniques have to reach the uterine lumen to collect the content of the endometrial walls, the cytobrush uses a small brush to collect the samples, meanwhile, the cytotype is a modification of the cytobrush technique where the sample is collected by a piece of tape.…”

Section: Diagnosis Of Uterine Diseasementioning

confidence: 99%

“…When biopsy technique is used, pieces of endometrial tissue are taken by using biopsy forceps, all these techniques require laboratory work for evaluation of the uterine samples. Cow-side methods such as metricheck device (Denis-Robichaud and Dubuc, 2015b;Ledgard et al, 2015;Bicalho et al, 2016) and gloved hand (Toni et al, 2015) are also methods to evaluate the vaginal content. These methods are used to assess different uterine diseases such as metritis, clinical or subclinical endometritis, and even cervicitis.…”

Section: Diagnosis Of Uterine Diseasementioning

confidence: 99%

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Uterine inflammation affects the reproductive performance of dairy cows: A review

Molina‐Coto

Lucy

2018

Mesoam. Agron.

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Incidence of post-partum uterine disease is an important concern in dairy cattle, because it affects its reproduction. Therefore, the objective of this review of literature was to generate a multifactorial overview about uterine diseases, and the reproductive performance of dairy cows, from a zootechnical approach. Dairy cows face multiple challenges around parturition. Immune suppression around calving, exposition to trauma and uterine bacterial contamination, metabolic diseases, lactation, and changes in management make dairy cows susceptible to uterine diseases. Most cows are able to eliminate uterine infection after calving, however, some cows keep uterine disease. Uterine disease may show clinical signs, but also silent signs that affect fertility as well. Poor reproductive performance is not caused by those signs by themselves, but due to alterations in ovarian and uterine function. Also, the problem of this silent signs is that farmers become aware of the disease when it has already caused negative effects on the reproductive performance. Sometimes, uterine disease is still present at the moment of the first service after calving. Uterine disease make it harder for cows to get pregnant because it affects the establishment and maintenance of pregnancy, being another cause for infertility, increasing the cull rate and decreasing incomes from the dairy industry. ResumenEl ganado lechero, entre otros desafíos, presenta enfermedades uterinas post parto que afectan su reproducción, por tanto, el objetivo de esta revisión de literatura fue generar una visión desde múltiples aristas acerca de las enfermedades uterinas y el desempeño reproductivo de la vaca lechera desde un enfoque zootécnico. La vaca lechera enfrenta múltiples retos en el momento del parto. Inmunosupresión alrededor del parto, exposición a trauma y contaminación uterina, enfermedades metabólicas, lactancia y cambios en el manejo, hacen a la vaca lechera un animal vulnerable de sufrir algún tipo de enfermedad uterina. La mayoría de las vacas pueden eliminar la infección Literature review Agron. Mesoam. 29(2):449-468, mayo-agosto, 2018

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The Metritis Complex in Cattle

Sheldon¹,

Sheldon²

2019

Veterinary Reproduction and Obstetrics

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Retained fetal membranesRetained fetal membranes (RFM) are defined as the failure of an animal to expel the fetal membranes, within 24 hours of the end of parturition. Retained placenta is an alternative name used for RFM. There is some variation in the literature about the duration of retention that defines the clinical disorder. Some prefer to define retention as being for12 hours, but the timing is arbitrary and most normal cows expel the fetal membranes within a few hours of parturition. The incidence of RFM varies amongst herds, but is typically 5 to 10% of animals.The importance of RFM is that they are associated with reduced milk yield and an increased risk of metritis. MetritisMetritis is most common within 10 days of parturition. Metritis is characterized by an enlarged uterus and a watery red-brown fluid, to viscous off-white purulent, uterine discharge, which often has a fetid odour (Sheldon et al 2006). The incidence of metritis varies between breed, country and herd, but in a study of the records from 97,318 cows in the USA, the lactation incidence of metritis, including RFM, was 21% (Zwald et al 2004). However, in some studies the incidence is as high as 40% of the herd. The associated clinical signs are used to classify the severity of disease, which varies from unapparent disease to fatal toxaemic metritis. Clinical endometritisClinical endometritis is defined as the presence of a purulent uterine discharge detectable in the vagina of cattle 21 days or more postpartum, or a mucopurulent discharge detectable in the vagina after 26 days postpartum (Sheldon et al 2006). The incidence of clinical endometritis is around 10 to 20%, with variation between breed, country and herd; a typical study reported that 16.9% of 1,865 dairy cows were affected in Canada (LeBlanc et al

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Influence of pathogenic bacteria species present in the postpartum bovine uterus on proteome profiles

Cited by 18 publications

References 53 publications

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

Genome-wide association study provides strong evidence of genes affecting the reproductive performance of Nellore beef cows

Uterine inflammation affects the reproductive performance of dairy cows: A review

The Metritis Complex in Cattle

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