Response surface methodology (RSM) is introduced into corrosion research as a tool to assess the effects of environmental factors and their interactions on corrosion behavior and establish a model for corrosion prediction in complex coupled environment (CCE). In this study, a typical CCE, that is, the corrosion environment of pipelines in gas field is taken as an example. The effects of environmental factors such as chloride concentration, pH value and pressure as well as their interactions on critical pitting temperature (CPT) were evaluated, and a quadratic polynomial model was developed for corrosion prediction by RSM. The results showed that the model was excellent in corrosion prediction with R 2 = 0.9949. CPT was mostly affected by single environmental factor rather than interaction, and among the whole factors, chloride concentration was the most influential factor of CPT.