Influence of Oxynitrided Surface in the Production of a Less Susceptible Titanium Surface to Skin-Borne Bacterial Adhesion

Abstract

There is a growing quest for an ideal biomaterial that shows appropriate cellular response and is not susceptible to microbial adhesion. In this study, commercial grade II titanium was submitted to RF/DC plasma surface modification at 2.2 mbar, using gas mixtures of argon, nitrogen, and oxygen at proportions 4:1:2 and 4:1:3. The surfaces were physically and chemically characterized. In order to evaluate bacterial response, the surfaces were exposed to Staphylococcus epidermidis. Oxynitrided samples, although having a higher roughness as compared with untreated samples, exhibited lower bacterial growth. This observation is probably due to the formation of different crystalline phases of nitrides and oxides caused by plasma treatment. The surface with highest contact angle and highest surface tension showed lower bacterial adhesion. These results were confirmed by scanning electron microscopy. The role of nitrogen in reducing bacterial adhesion is clear when this material is compared with untreated titanium, on which only an oxide film is present.

Plant Natural Products Targeting Bacterial Virulence Factors

“…174 Icariin (139), a flavonol glycoside, showed concentration-dependent antibiofilm activity, eradicating Propionibacterium acnes biofilms. 175 Computer-based analyses using the crystal structure of TraR (A. tumefaciens) and in vitro assays identified the flavones baicalein (126) and baicalin (127) as potential QSIs against P. aeruginosa. 154 susceptible to ampicillin, demonstrating that this compound exhibited a marked synergistic activity.…”

“…One alternative regarding nonbiotic surfaces, such as medical devices, is to produce materials less prone to microbe adhesion. In this regard, several physical and chemical features of a given surface may be modified in order to achieve the best anti-infective performance while safe biocompatibility is maintained, following the so-called concept race for the surface . , Briefly, surface modifications may be carried out on the basis of (i) a chemical coating or grafting of the surface using antiadhesive or antimicrobials agents, and (ii) physical treatments of the surface, such as those induced by ionic plasma discharge. − Another scenario in this context is to inhibit adhesion by interfering with the production of microbial appendages, such as pili, curli, and flagella. The second messenger c-di-GMP has also been implicated in bacterial adhesion, including the stimulation of the synthesis of adhesins (for relevant details, see refs and ).…”

Novel antibacterial silver coating on PET fabric assisted with hollow‐cathode glow discharge

“…The wettability test was carried out by contact angle measurement to estimate the surface energy of modified material. The contact angle measurements, based on the sessile drop technique, were carried out in an apparatus developed in Lab Plasma, as described elsewhere 37,38 . The liquids used in this work were water, formamide, and glycerol, and measured contact angles are presented in Table 1.…”

Ionic Oxidation in Cathodic Cage of Titanium CP Grade II

“…Titanium is also found in the form of oxide, the best known as TiO 2 . It is widely used because it is chemically inert and has characteristics such as biocompatibility, good dielectric properties, excellent absorption in the ultraviolet spectrum, high stability and is applied in different industrial areas such as solar cells, environmental purifiers, biomaterials, protective layers against corrosion, nanomaterials [3][4][5][6] . Among the existing titanium oxides compounds, titanium dioxide, TiO 2 , draws attention to possess important properties scientifically and industrially, and can be found in different crystalline structures, the best known being brookite, anatase and rutile.…”