Influence of Organic and Functional Dyspepsia on Work Productivity: The HEROES-DIP Study

Sander, Guilherme Becker; Mazzoleni, Luiz Edmundo; Francesconi, Carlos Ferrnando de Magalhães; Balbinotto, G.; Mazzoleni, Felipe; Wortmann, André Castagna; Cardoso, Israel de Quadros; Klamt, Andreas; Milbradt, Tobias Cancian

doi:10.1016/j.jval.2011.05.021

Cited by 61 publications

(58 citation statements)

References 20 publications

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“…Similarly, a case control study [50] conducted at Noble Higher Clinic; Addis Ababa, Ethiopia using non-invasive tests (H. pylori stool antigen) showed that there was a significant difference between dyspeptic and non-Dyspeptic participants. Even though, many studies [32,[51][52][53] conducted to investigate the association between Dyspepsia and H. pylori on rapid antibody, almost all found that H. pylori infection was significantly associated with Dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

“…There are studies that showed the seroprevalence of H. pylori in different countries. These studies found that the prevalence vary with geographic location, ethnicity, and demographic factors of the studied population [32]. Studies revealed that the prevalence increases in dyspeptic patients than non dyspeptic individuals and dyspeptic symptoms account 10% of hospital admission in Ethiopia [33].…”

Section: Introductionmentioning

confidence: 94%

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Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Ayele¹,

Molla²

2017

Clin Microbiol

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Dyspepsia is a common symptom of gastrointestinal disease with global distribution. The prevalence of this disorder varies between 3% and 40%. Dyspeptic symptoms account 10% of hospital admissions in Ethiopia. The aim of this study was to determine the contributing factors for dyspepsia at Yirga cheffe primary hospital, Southern Ethiopia.: A case control study design was conducted between July 6, 2016 and August 10, 2016 on a total of 168 patients at Yirga cheffe primary hospital, South Ethiopia. The Helicobacter pylori (H. pylori) stool antigen test was used to analyze the stool samples and a face to face interview was taken to assess other contributing factors for the infection. Ethical clearance and informed consents was obtained before data collection. Logistic regression analysis was used to estimate odds ratio (adjusted with 95% confidence interval) of positive responses to the different risk factors. Comparisons between groups were assessed with chi-square test and a P-value of <0.05 was considered statistically significant. Helicobacter pylori antigen was detected in 13 of the 168. Helicobacter pylori infection was six times more associated with dyspeptic patients than non-Dyspeptic individuals. Anxiety and depression was six and three times more likely associated with dyspepsia, respectively. Although dyspepsia was greater among male, and peaked in the age groups of 21-30 years old, the association was not statistically significant. Moreover, patients who consume foods containing peppercorn ("key wot") have high chance of developing Dyspepsia. Study subjects who depend on untapped drinking water sources, treating their drinking water, smoking habit, chewing khat, washing their hand with soap, and their toilet with flush tank were not significantly associated with dyspepsia (P>0.05). Thus, early diagnosis of H. pylori, psychological treatment of patients and food habit of the individuals should give attention to prevent and control Dyspepsia even though additional studies need to be conducted.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Dyspepsia and Associated Risk Factors at Yirga Cheffe Primary Hospital, Southern Ethiopia

Ayele¹,

Molla²

2017

Clin Microbiol

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“…Health economic data indicate that functional dyspepsia has high direct and indirect costs, specifically driven by the high prevalence of comorbidity 18,43 , but both organic dyspepsia and functional dyspepsia have similar economic effects 44 .…”

Section: Epidemiologymentioning

confidence: 99%

“…The most widely used generic measure, the Short Form 36-Item Health Survey (SF-36) 222 , assesses eight dimensions of health: physical functioning, social functioning, Nature Reviews | Disease Primers Fatty foods , milk and dairy Alcohol , coffee Red meat Carbonated drinks Vegetables Spicy foods Carbohydrates and wheat (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53) Citrus (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) Figure 5 | Foods and food groups frequently associated with symptom induction or exacerbation in functional dyspepsia. Offending foods reported by patients with functional dyspepsia include fatty food (for example, fried food [179][180][181]187,191 ), alcohol 179,180 , dairy products 179,181 , coffee [179]…”

Section: Quality Of Lifementioning

confidence: 99%

Functional dyspepsia

Enck¹,

Azpiroz

Boeckxstaens

et al. 2017

Nat Rev Dis Primers

254

247

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| Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation. A genetic predisposition is probable but less evident than in other functional gastrointestinal disorders, such as irritable bowel syndrome (IBS). Psychiatric comorbidity and psychopathological state and trait characteristics could also play a part, although they are not specific to functional dyspepsia and are less pronounced than in IBS. Possible differential diagnoses include Helicobacter pylori infection and peptic ulceration. Pharmacological therapy is mostly based on the subtype of functional dyspepsia, such as prokinetic and fundus-relaxing drugs for PDS and acid-suppressive drugs for EPS, whereas centrally active neuromodulators and herbal drugs play a minor part. Psychotherapy is effective only in a small subset of patients, whereas quality of life can be severely affected in nearly all patients. Future therapies might include novel compounds that attempt to treat the underlying gastric and duodenal inflammation. NATURE REVIEWS | DISEASE PRIMERS VOLUME 3 | ARTICLE NUMBER 17081 | 1 PRIMER © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .standard therapy for gastro -oesophageal reflux disease. Paediatric dyspeptic symptoms are being addressed in a separate classification effort 10 . This Primer covers functional dyspepsia in adults only, although we sporadically refer to paediatric functional dyspepsia when similarities exist. EpidemiologyThe population prevalence of functional dyspepsia is quite variable across the globe, with overall high numbers (10-40%) in Western countries and low numbers (5-30%) in Asia, independent of the respective functional dyspepsia definitions 11 . A large-scale health and nutrition survey from France 12 (which involved >35,000 people) identified that 15% of individuals had suspected functional dyspepsia, 28% had irritable bowel syndrome (IBS) and 6% had both. The population of patients who are affected by both IBS and functional dyspepsia has been reported to range between 10% and 27% in previous studies 13 and to approach 30% in popu lation samples; it could be even higher in specific populations 14,15 . This observation has given rise to the term 'overlap syndrome' (REF. 13), which calls into question the sensitivity and specificity of the Rome criteria, at least for IBS and functional dyspepsia. This argument is also supported by the observation that patients with functional dyspepsia m...

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“…2 Up to 40% of persons who have functional dyspepsia consult a physician, 3 and the condition negatively affects attendance and productivity in the workplace. 4 Functional dyspepsia has substantial financial implications for patients, health care organizations, and society as a whole; costs associated with the condition in the United States in 2009 were in excess of $18 billion. 5 It is therefore important that physicians be able to recognize functional dyspepsia, use investigations and diagnostic tests judiciously, and recommend effective treatments, in order to minimize the potential adverse social and economic effects of the condition.…”

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confidence: 99%