Influence of nutritional factors and the PON1 C(-107)T polymorphism on paraoxonase-1 activity in childhood

Sigales, Tainá S.; Uliano, Gabriela; Muniz, Ludmila Correa; Barros, Carlos Castilho; Schneider, Augusto; Valle, Sandra Costa

doi:10.1016/j.jped.2019.02.004

Cited by 1 publication

(1 citation statement)

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“…7 Paraoxonase-1 and lecithin-cholesterol acyltransferase are enzymes with antioxidant activities. [8][9][10] The ferric reducing antioxidant power assay is used to measure the antioxidant potential of body samples. 11 Also, advanced glycation end products are glycated proteins that lead to the formation of reactive oxygen species through interactions with advanced glycation end product-specific receptors and result in increased oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and antioxidant markers in patients with alopecia areata: A comparative cross-sectional study

Shakoei

Mirmiranpoor²,

Nakhjavani³

et al. 2022

IJDVL

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Background Alopecia areata is a chronic inflammatory skin disease. Oxidative stress may contribute to the pathogenesis of this condition. Aim To evaluate the serum oxidative stress markers and antioxidant capacity in patients with alopecia areata. Methods This cross-sectional study was performed on 40 patients with alopecia areata and 40 healthy controls. The fasting blood sugar, C-reactive protein, lipid profile, and serum oxidative markers, including advanced glycation end products and advanced oxidation protein products, were measured in this study. Also, antioxidant enzymes, including paraoxonase-1, lecithin-cholesterol acyltransferase and serum ferric-reducing antioxidant power, were determined. Results The serum levels of advanced glycation end products and advanced oxidation protein products were significantly higher in patients with alopecia areata, compared to the controls (P < 0.001), whereas the levels of ferric-reducing antioxidant power, paraoxonase-1 and lecithin-cholesterol acyltransferase were significantly lower in patients with alopecia areata, compared to the controls (P < 0.001). The mean fasting blood sugar level was significantly higher in patients with alopecia areata, compared to the controls. The ferric reducing antioxidant power level was significantly associated with the percentage of hair loss (P = 0.01, r = 0.4) and the serum C-reactive protein level (P = 0.03, r = -0.3) in patients with alopecia areata. Limitations Since the current study had a cross-sectional design, no cause-effect relationship was established between alopecia areata and oxidative stress. The sample size of our study was also small. Conclusion Based on the present results, the oxidant-antioxidant enzymatic system is impaired in alopecia areata due to the increased oxidative products and decreased antioxidant activity.

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