Influence of Nucleoshuttling of the ATM Protein in the Healthy Tissues Response to Radiation Therapy: Toward a Molecular Classification of Human Radiosensitivity

Granzotto, Adeline; Benadjaoud, Mohamed Amine; Vogin, Guillaume; Devic, Clément; Ferlazzo, Mélanie L.; Bodgi, Larry; Pereira, Sandrine; Sonzogni, Laurène; Forcheron, Fabien; Viau, Muriel; Etaix, Aurélie; Malek, Karim; Mengue-Bindjeme, Laurence; Escoffier, Clémence; Rouvet, Isabelle; Zabot, M. T.; Joubert, Aurélie; Vincent, Anne; Venezia, Nicole Dalla; Bourguignon, M.; Canat, Edme-Philippe; d’Hombres, A.; Thébaud, Estelle; Orbach, Daniel; Stoppa‐Lyonnet, Dominique; Radji, Abderraouf; Doré, Éric; Pointreau, Y.; Bourgier, C.; Leblond, Pierre; Defachelles, Anne‐Sophie; Lervat, Cyril; Guey, Stéphanie; Feuvret, L.; Gilsoul, F.; Berger, Claire; Moncharmont, Coralie; Laroche, Guy de; Moreau-Claeys, M.-V.; Chavaudra, N.; Combemale, P.; Biston, Marie-Claude; Malet, C.; Martel-Lafay, Isabelle; Laude, C.; Hau-Desbat, Ngoc-Hanh; Ziouèche, A.; Tanguy, R.; Sunyach, Marie‐Pierre; Racadot, S.; Pommier, P.; Claude, L.; Baleydier, Fréderic; Fleury, B.; Crevoisier, R. de; Simon, Jean‐Marc; Verrelle, Pierre; Peiffert, D.; Belkacémi, Yazid; Bourhis, Jean; Lartigau, Éric; Carrié, C.; Vathaire, Florent de; Eschwège, F.; Puisieux, Alain; Lagrange, Jean‐Léon; Balosso, Jacques; Foray, Nicolas

doi:10.1016/j.ijrobp.2015.11.013

Cited by 94 publications

(187 citation statements)

References 37 publications

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“…Many other immunofluorescent markers have been developed and permit dynamic cellular investigations: is the right protein at the right place at the right time (e.g., ATM, Rad 51, MRE11, ...) (Granzotto et al, 2016)? These new techniques allow nowadays a functional evaluation of DNA damage signaling and pathway responses (DDR) after IR exposure; the corresponding observations are quite significant.…”

Section: Radiation Biologymentioning

confidence: 99%

“…Therefore studies on biological samples from human cell and tissue collections (e.g., the United States Transuranium & Uranium Registries (USTUR) or the COPERNIC collection of fibroblasts from radiosensitive patients (Granzotto et al, 2016), ...) should be encouraged. Multiple investigations on the same tissues will provide a better and more complete view of cellular mechanisms of response to IR.…”

Section: Radiation Biologymentioning

confidence: 99%

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-In recent years, Radioprotection, the journal of the French Radiation Protection Society (SFRP) has evolved to an international peer-reviewed journal. This evolution, together with a recent change in the editorial board of the journal, stimulated a reflexion on the aims and topics of interest for the journal. The starting point of this reflexion is an analysis by the editorial board of the current issues in the various fields of radiation protection and the associated challenges in corresponding research areas such as epidemiology, fundamental radiation biology, biological and physical dosimetry, radiation toxicology, ecotoxicology and environmental radiation protection. This article presents the results of this think tank action and paves the way for an evolution of the aims and scope of the journal Radioprotection.

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Section: Radiation Biologymentioning

confidence: 99%

Section: Radiation Biologymentioning

confidence: 99%

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“…D'autres traceurs immunofluorescents ont été développés, permettant une analyse dynamique : la bonne protéine est-elle au bon endroit au bon moment (ATM, Rad 51, MRE11...) (Granzotto et al, 2016) ? Au total nous avons actuellement une évaluation fonctionnelle dynamique de la signalisation des dommages induits à l'ADN par les RI et des voies de leur réparation (DDR).…”

Section: La Radiobiologieunclassified

“…Des travaux sur des collections d'échantillons ou de matériel biologique humain (comme le registre américain USTUR [United States Transuranium & Uranium Registries]) ou la collection COPERNIC de fibroblastes de patients radiosensibles (Granzotto et al, 2016) doivent être encouragés. De même des investigations par des méthodes multiples sur les mêmes échantillons permettront une compréhension plus fine et plus sûre des mécanismes mis en jeu.…”

Section: La Radiobiologieunclassified

Radioprotection : quel avenir ?

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Radioprotection

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“…The functional proximity of BRCA proteins and of ATM is in favor of the potential usefulness of nuclear pATM assays developed for individual radiosensitivity screening (Granzotto et al, 2016;Ferlazzo et al, 2017) to individual radio-susceptibility to cancer screening.…”

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confidence: 99%

Editorial Comment on: Radiation induced breast cancer risk in BRCA mutation carriers from low-dose radiological exposures: a systematic review

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Radioprotection

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Influence of Nucleoshuttling of the ATM Protein in the Healthy Tissues Response to Radiation Therapy: Toward a Molecular Classification of Human Radiosensitivity

Cited by 94 publications

References 37 publications

What's next inRadioprotection?

What's next inRadioprotection?

Radioprotection : quel avenir ?

Editorial Comment on: Radiation induced breast cancer risk in BRCA mutation carriers from low-dose radiological exposures: a systematic review

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