Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum

Mohammed, D.; Crowther, Jonathan; Matts, Paul J.; Hadgraft, Jonathan; Lane, Majella E.

doi:10.1016/j.ijpharm.2012.11.043

Cited by 54 publications

(48 citation statements)

References 25 publications

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“…The importance of lipids in the skin barrier was demonstrated in another study on AD patients by Simpson et al [34]: TEWL decreased following the 4-week application of a moisturizer containing niacinamide and a ceramide precursor, along with increased ceramide levels. Niacinamide, a compound of vitamin B 3 which has been shown to increase the levels of SC ceramides [35], was also tested on healthy skin, resulting in a lower increase of TEWL following tape stripping [36]. On the other hand, a study by Boireau-Adamezyk et al [37] showed that the relationship between lipids and TEWL is not straightforward in the facial area, characterized by higher levels of ceramides, cholesterol and the lipid/protein ratio, as well as hydration, and yet by a poor barrier function indicated by high TEWL.…”

Section: Resultsmentioning

confidence: 99%

Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

Falcone

Uzunbajakava²,

Varghese

et al. 2015

Skin Pharmacol Physiol

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Skin barrier function, confined to the stratum corneum, is traditionally evaluated using established, noninvasive biophysical methods like transepidermal water loss, capacitance and conductance. However, these methods neither measure skin molecular composition nor its structure, hindering the actual causes of skin barrier change or impairment. At the same time, confocal Raman microspectroscopy (CRS) can directly measure skin molecular composition and structure and has proven itself to be a powerful technique for biomolecular analysis. The aims of this literature review were to evaluate noninvasive biophysical methods in view of CRS and to outline a direction towards more specific and informative skin measurement methods. We address this by investigating, for the first time, the relation between in vivo assessment of the skin barrier using indirect biophysical methods and the actual skin composition and structure as given by CRS, and emphasize the high potential of CRS for dermatology and cosmetic sciences. CRS acceptance in these fields will require close collaboration between dermatologists, skin scientists and spectroscopy experts towards simplifying the technology and creating robust, rapid, easy-to-use and less expensive CRS applications.

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Section: Resultsmentioning

confidence: 99%

Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

Falcone

Uzunbajakava²,

Varghese

et al. 2015

Skin Pharmacol Physiol

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“…Acne is associated with impaired skin barrier function, as demonstrated by increased transepidermal water loss (TEWL) . Nicotinamide has been shown to decrease TEWL, thus improving the skin barrier, which is another potentially beneficial effect for patients with acne …”

Section: Acne and Rosaceamentioning

confidence: 99%

“…Impaired skin barrier function is also implicated in the pathogenesis of rosacea . As indicated, nicotinamide improves the skin barrier function; thus it may be of benefit for rosacea …”

Section: Acne and Rosaceamentioning

confidence: 99%

Nicotinamide and the skin

Chen

Damian

2014

Aust J Dermatology

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Nicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly-ADP-ribose-polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne, rosacea, ageing skin and atopic dermatitis. In particular, recent studies have also shown it to be a potential agent for reducing actinic keratoses and preventing skin cancers.

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“…The broad clinical effects of niacinamide are felt to be from a variety of potential mechanisms of action including anti-inflammatory effects via inhibition of leukocyte chemotaxis, lysosomal enzyme release, lymphocytic transformation, mast cell degranulation, bacteriostatic effects against Propionibacterium acnes, inhibition of vasoactive amines, preservation of intracellular coenzyme homeostasis, and decreased sebum production [74,75]. Niacinamide also increases the thickness of the epidermis [76] while inducing de novo ceramide production through up-regulated expression of serine palmitoyltransferase, the rate-limiting enzyme in sphingolipid synthesis.…”

Section: Niacinamidementioning

confidence: 99%

Irritant Contact Dermatitis: Mechanisms to Repair

Eberting¹

2014

J Clin Exp Dermatol Res

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Irritant contact dermatitis is an extremely common condition resulting from epidermal exposure to any number of skin irritants. Upon contact with skin irritants, the epidermis develops many identifiable problems including specific epidermal lipid deficiencies, elevated epidermal pH with concomitant suppression of epidermal lipid production, pHdependent susceptibility to infection, inflammation, and aberrant calcium gradients. By addressing these problems simultaneously, and through irritant avoidance, the treatment of irritant contact dermatitis can be maximized.

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Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum

Cited by 54 publications

References 25 publications

Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

Microspectroscopic Confocal Raman and Macroscopic Biophysical Measurements in the in vivo Assessment of the Skin Barrier: Perspective for Dermatology and Cosmetic Sciences

Nicotinamide and the skin

Irritant Contact Dermatitis: Mechanisms to Repair

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