Influence of Neonatal and Maternal Factors on the Prevalence of Vernix Caseosa

Monteagudo, Benigno; Labandeira, J.; León-Muiños, Elvira; Romarís, Rosa; Ramírez-Santos, A.; González‐Vilas, D.; Fernández-Prieto, R.; Toribio, Jaime

doi:10.1016/j.adengl.2011.11.002

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…At birth, both the presence of the VC and the active secretion of sebaceous lipids (sebum) at the neonate skin surface have the potential to affect the observations reported by this study. The VC is a protective, hydrophobic layer comprising water (80·5%), lipids and proteins (8–10% each), reported to be visibly present in around half of neonates at birth . Previous studies have identified that VC retention maintains SC hydration and supports acid mantle development, contributed to in part by providing a source of FAA to the superficial SC .…”

Section: Discussionmentioning

confidence: 99%

Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

Chittock

Cooke

Lavender

et al. 2016

British Journal of Dermatology

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Conflicts of interest disclosure: None to declare. What's already known about this topic? From birth the acidification and hydration of the infant stratum corneum to adult levels suggests transitory mechanisms underlying differentiation and desquamation. What does this study add? Superficial chymotrypsin-like protease activity and natural moisturising factors (NMF) increase from birth to 4 weeks of age and differ to adults. Impaired barrier function at birth is accompanied by elevated protease activity and reduced NMF, highlighting why certain infants are predisposed to epidermal barrier breakdown and the development of atopic dermatitis. AbstractBackground: From birth, the functional properties of the neonatal epidermal barrier mature whereby

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Section: Discussionmentioning

confidence: 99%

Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

Chittock

Cooke

Lavender

et al. 2016

British Journal of Dermatology

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“…Possible factors include oligohydramnios and excessive manipulation of the fetus during difficult labor, both of which would increase concentration of vernix caseosa in amniotic fluid [10]. Other considerations include maternal and fetal factors affecting the prevalence of vernix caseosa itself, such as multiparous mothers who ingest medications and dietary supplements during pregnancy, female infant, fullterm gestation, and high birth weight [31].…”

Section: Discussionmentioning

confidence: 99%

Vernix Caseosa Peritonitis Causing Acute Abdomen After Cesarean Section: A Case Series

et al. 2022

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Objective:Rare disease Background:Vernix caseosa peritonitis (VCP) is a rare complication that typically presents following an otherwise uneventful cesarean section. Leakage of vernix caseosa into the peritoneum is thought to elicit a granulomatous foreign body reaction. Symptoms can be similar to other acute abdominal conditions, and diagnosis is confirmed by intraoperative findings and histological examination. Peritoneal lavage with supportive measures is the mainstay of treatment and recovery. Case Reports:Case 1 was a 30-year-old woman who developed right iliac fossa pain, fever, tachycardia, and tachypnea less than a week after her lower segment cesarean section (LSCS). She underwent a laparoscopy for a peritonitic abdomen and concern for intra-abdominal sepsis. A peritoneal biopsy demonstrated histological changes consistent with VCP.Case 2 was a 39-year-old woman who underwent a LSCS. After discharge, she re-presented with generalized abdominal pain. With computed tomography (CT) scan findings suggestive of appendicitis, an appendectomy was performed, and vernix caseosa was detected in all quadrants.Case 3 was a 33-year-old woman who presented with fever, vomiting, diarrhea, and iliac fossa pain 9 days following an LSCS. She was given analgesia and antibiotics for a pelvic fluid collection noted on CT scan. She represented with tense swelling and pain above her cesarean section incision. Laparoscopy revealed adhesions over the lower abdomen and pelvis and white plaques suggestive of vernix caseosa along the peritoneal side walls. Conclusions:The rising incidence of cesarean births worldwide creates the potential for increased numbers of VCP cases.Greater recognition of VCP is warranted to prevent unnecessary procedures.

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“…Nevertheless vernix caseosa is not present in all newborns. Monteagudo et al (10) observed this material in 43% of newborns infants.…”

Section: Discussionmentioning

confidence: 99%

Vernix caseosa peritonitis: report of two cases

Val-Bernal¹,

Mayorga²,

García-Arranz³

et al. 2014

TJPATH

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Vernix caseosa peritonitis is a rare complication caused by inflammatory response to amniotic fluid spilled into the maternal peritoneal cavity. Most cases occur after cesarean section. We discuss herein two patients, aged 33 and 29 years, who presented with vernix caseosa peritonitis seven to nine days after a cesarean delivery. Laparotomy was performed and it revealed neither uterine rupture nor other surgical emergencies, but cheesy exudates on the serosal surface of all viscera. Appendicectomy was performed. Histopathologic study revealed acute fibrinous serositis and a mixed cellular infiltrate, rich in neutrophils, around fetal desquamated anucleate squamous cells. Patients´ recovery was complete. Clinical diagnosis of vernix caseosa peritonitis should be suspected in patients presenting post-cesarean section with an acute abdomen. Distinctive histopathologic findings allow making the correct diagnosis. Vigilant monitoring after diagnosis is essential as delayed morbidities may appear.

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Influence of Neonatal and Maternal Factors on the Prevalence of Vernix Caseosa

Cited by 7 publications

References 10 publications

Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

Development of stratum corneum chymotrypsin-like protease activity and natural moisturizing factors from birth to 4 weeks of age compared with adults

Vernix Caseosa Peritonitis Causing Acute Abdomen After Cesarean Section: A Case Series

Vernix caseosa peritonitis: report of two cases

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