Influence of narrowband UVB phototherapy on vitamin D and folate status

Cicarma, Emanuela; Mørk, Cato; Porojnicu, Alina Carmen; Juzeniene, Asta; Tam, Tran Thi Thu; Dahlback, Arne; Moan, Johan Emelian

doi:10.1111/j.1600-0625.2009.00987.x

Cited by 67 publications

(73 citation statements)

References 43 publications

(58 reference statements)

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“…16 Our observation that individuals with low initial concentrations of 25(OH)D have a higher response to UVBnb irradiation confirmed previous reports. 4,11,17 We did not find any correlation between the cumulative dose of UVBnb and the increase of serum 25(OH)D at 12 weeks, in accordance with Osmancevic et al 14 but in contradiction to a recent study. 18 The explanation might be that 25(OH)D reaches a plateau after 3 weeks already, and that exposure to additional UVBnb may not result in a continued proportional increase in serum vitamin D. UVBnb therapies but significant only under UVBbb therapy.…”

Section: -15supporting

confidence: 72%

Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3

Feldmeyer

Shojaati

Spanaus³

et al. 2013

Journal of the American Academy of Dermatology

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BACKGROUND: Ultraviolet (UV) B radiation increases serum 25-hydroxyvitamin-D3 [25(OH)D], but the influence of UVA1 and UVA/narrowband UVB (UVBnb) phototherapy on serum vitamin D is unknown. OBJECTIVE: We sought to investigate the influence of UVBnb, UVA1, and UVA/UVBnb phototherapy on serum levels of 25(OH)D and related parameters in patients with an inflammatory skin condition. METHODS: 25(OH)D, as well as calcium, parathormone, phosphate, and albumin were measured before therapy, 2 weeks after start, and after completion of the phototherapy. Diagnoses were divided in 4 groups: atopic dermatitis, psoriasis, morphea, and others. RESULTS: We surveyed 116 dermatologic patients undergoing phototherapy with UVA1 (n = 38), UVA/UVBnb (n = 30), or UVBnb (n = 48) 2 to 3 times a week for 53 to 90 days. UVBnb phototherapy increased serum 25(OH)D from 22.1 to 39.5 ng/mL after the therapy (P < .001). The lower the baseline 25(OH)D level was, the steeper the increase in 25(OH)D was upon application of UVBnb phototherapy. UVA/UVBnb therapy also increased serum 25(OH)D, from 23.9 to 50.3 ng/mL (P = .003). Conversely, in the UVA1 therapy group, 25(OH)D serum levels decreased significantly from 21.9 to 19.0 ng/mL (P < .001). LIMITATIONS: The study design was open trial without randomization. An influence of a precise skin disease cannot be excluded because of the heterogeneous diagnoses. Bias may have arisen from patient preference for treatment at our center, referral, unrecognized differences in underlying skin disease, and other factors.

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Section: -15supporting

confidence: 72%

Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3

Feldmeyer

Shojaati

Spanaus³

et al. 2013

Journal of the American Academy of Dermatology

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“…Level of vitamin D decreased after treatment in 3 patients (2 males and 1 female) with the initial normal level of vitamin D, which was at the normal range for male patients, but it was inadequate in the female patient; and this was consistent with previous studies (13,14). Such a similar relationship in response to 25 (OH) D to radiation and its relationship with initial level of 25 (OH) D in a study is seen in our sun bed in healthy individuals as well, but it was not associated with body mass index, oral intake of vitamin D, and gender.…”

Section: U N C O R R E C T E D P R O O Fsupporting

confidence: 90%

“…Only 10% to 15% of the 7-Dehydrocholesterol can be converted into the previtamin D in response to sunlight. Some believe that only 7% of 7-Dehydrocholesterol can be converted into the previtamin D. Thus, it seems that the availability of the substrate may be variable: people with a base level lower than 25 (OH) D, which could also increase in response to UVB, have more availability of substrate compared to those with a higher base level of 25 (OH) (13).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

Evaluation of Serum Vitamin D Levels in Patients with Vitiligo Undergoing NBUVB (Narrowband UV-B) Therapy

Omidian

Asadian

2017

Jundishapur J Nat Pharm Prod

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Background: Vitamin D increases the contents of tyrosinase in cultured human melanocytes, which raises its possible role in modulating melanogenesis. Objectives: In this study, the level of 25 (OH) D was measured before and after NBUVB therapy and its relationship with outcome of NBUVB therapy in patients with vitiligo was also assessed. Methods: This study was conducted on 30 patients with generalized vitiligo (less than 30% body surface) and 30 healthy individuals without age and gender limitations. The patients received NBUVB therapy 2 times a week for 15 weeks. We measured the serum vitamin D level and involvement area (VASI score, vitiligo area, and severity index) at baseline and 30 sessions post treatment. Results:The level of vitamin D increased significantly compared to baseline measurements. Vitamin D level changes were not significantly associated with clinical outcome in which VASI score decreased. Conclusions: Vitamin D did not improve clinical outcomes. Thus, we suggest that further studies be conducted to understand the mechanisms of pigmentation due to NBUVB therapy in vitiligo.

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“…The increase in 25(OH)D was higher in the BUVB treated patients when compared to the NBUVB (p=0.008) and heliotherapy (p=0.017) treated groups. Low-dose NBUVB treatment significantly increased vitamin D status in patients with psoriasis, atopic eczema and other skin disorders with low initial levels of 25(OH)D (60,61). Within the following intervention studies, age showed no correlation with the observed increase in 25(OH)D levels (57,58,62).…”

Section: The Effects Of Phototherapy On Vitamin D Status In Patients mentioning

confidence: 87%

UVB and Vitamin D in Psoriasis

Osmancevic¹

2012

Psoriasis

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Influence of narrowband UVB phototherapy on vitamin D and folate status

Cited by 67 publications

References 43 publications

Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3

Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3

Evaluation of Serum Vitamin D Levels in Patients with Vitiligo Undergoing NBUVB (Narrowband UV-B) Therapy

UVB and Vitamin D in Psoriasis

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