Influence of Nanocluster Molybdenum Polyoxometalates on the Morphofunctional State of Fibroblasts in Culture

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

“…This increases the membrane surface, as was recorded by means of optical, electron, and scanning probe microscopy (a comparison of images obtained by different methods is of interest), and can lead, in turn, to an additional increase in its ability to interact with drugs. The obtained results confirm the prospects for the application of POMs in the field of biomedicine, including the use of Mo 132 in oncological practice [163]. FIG.…”

“…In the course of further investigation of the action of POMs at the cellular level, the effect of Mo 72 Fe 30 and Mo 132 on normal and transformed fibroblasts was assessed [162]. The effect of polyoxometalates on cell survival in culture and their cytotoxic action have been studied [163]. Human dermal fibroblasts (HDF) are more resistant to Mo 72 Fe 30 .…”

The Electrostatic‐Mediated Formation of a Coordination Complex: the Trapping and Release of an Antitumor Drug with an Anthracycline Core from {Mo72Fe30}‐Based Ensembles

“…the {Mo 72 Fe 30 } possesses several advantages. They do not disturb the integrity of cell membrane [29] as compared with magnetite nanoparticles which also induce autophagosome accumulation and mitochondrial damage [30] . Furthermore, unlike magnetic nanoparticles [31] and liposomes [32] the {Mo 72 Fe 30 } can aggregate in a very slow fashion in high concentrated aqueous solution [33] that is important to avoid thrombogenic action.…”