The physicochemical properties and influence on living organisms of nanocluster polyoxomolybdates as prospective bioinspired substances (based on materials from the plenary lecture)

Остроушко, А. А.; Gagarin, I.D.; Grzhegorzhevskii, K. V.; Гетте, И. Ф.; Vlasov, Dmitry Yu.; Ermoshin, Alexander; Antosyuk, O. N.; Shikhova, Svetlana V.; Данилова, И. Г.

doi:10.1016/j.molliq.2019.110910

Cited by 18 publications

(15 citation statements)

References 35 publications

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“…Owing to the pH‐dependent destruction of giant POMs in aqueous media, these nanoclusters can reversibly bind the 10–20‐fold molecular excess of cationic dye without loss of colloidal stability and deactivate their fluorescence signal. Administrated into some living tissues through injection or iontophoresis, such associates will gradually release the dye molecules during POM destruction at physiological pH (7.2–7.4). This will partially solve the problem of dye photobleaching under a laser beam in fluorescent visualization techniques: new dye molecules will be released in place of the photodegraded ones and stain the tissue.…”

Section: Resultsmentioning

confidence: 99%

Fundamental Aspects of Xanthene Dye Aggregation on the Surfaces of Nanocluster Polyoxometalates: H‐ to J‐Aggregate Switching

Fazylova

Shevtsev

Михайлов

et al. 2020

Chemistry A European J

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The induced aggregation of the xanthenedye rho-damineB (RhB) on metal oxide centers belonging to the highly symmetric surfaces of precise nanoscale templates with Keplerate (Mo 132 )o rtoroidal (Mo 138 )s tructures has been studied. With the joint use of the Langmuir isotherma nd full Stern-Volmer models, the thermodynamic reasons for dye adsorption on the nanocluster surface, such as amixture of monomer,H -aggregate (H-dimer), and J-aggregate forms (which can coexist or switch one into another under the exact conditions), were established:t his was shown through UV/Vis and fluorescence spectroscopies. By using the frame-work of the excitonm odel, it is shownt hat the angle( a)b etweent he transition dipole moments of RhB is very sensitive to surface strain inside the dye sub-monolayer.A saresult, it is possible to switch from H-to J-aggregates by the postfunctionalization of polyoxometalate (POM)-RhB associates by the surfactant bilayer shell, which allows the surface strain to grow.R ecommendations are provided for managing the appearance of H-or J-aggregates on metal oxide (or polyelectrolyte) surfacesd uring photovoltaico rb ioimaging applications.[a] V. Fazylova, N. Shevtsev,S .M ikhailov, Prof. [b] G. Kim Institute of Organic Synthesis Ural Branch of the Russian Academyo fSciences 22 AkademicheskayaS t.,6 20990 Ekaterinburg (Russia) Supporting information and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

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Section: Resultsmentioning

confidence: 99%

Fundamental Aspects of Xanthene Dye Aggregation on the Surfaces of Nanocluster Polyoxometalates: H‐ to J‐Aggregate Switching

Fazylova

Shevtsev

Михайлов

et al. 2020

Chemistry A European J

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“…The content of heat shock proteins in the thymus and spleen was also studied, and it was shown that POM administration is accompanied by an increase in the number of cells containing Hsp60 and Hsp70 heat shock proteins in both organs [108,132,159]. The increased expression of heat shock proteins in the thymus [160], despite the presence of a hematothymic barrier, gives reasons to suppose the ability of POM to overcome the histo-hematic barriers of immune privileged organs [161]. Taking into account the results of the ongoing studies [161], it has been shown that POM can also exert a similar effect on other organs with special histo-hematic barriers, in particular, hematoencephalic, hematoophthalmic, hemato-testicular, etc.…”

Section: Poms Impact At the Cellular-molecular Levelmentioning

confidence: 99%

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Ostroushko¹,

Grzhegorzhevskii²,

Medvedeva³

et al. 2021

Nanosystems: Phys. Chem. Math.

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The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.

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“…Пористый сферический нанокластерный полиоксометаллат (ПОМ) с уникальной структурой кеплератного типа [1,2] , как и родственные кеплератные структуры, представляет интерес в различных областях, таких как биомедицинская отрасль [3][4][5]. Указывается на его применимость в катализе [6,7].…”

Section: Introductionunclassified

Influence of the Nanocluster {Mofe} Polyoxometalate on Oxidation of Iodide-Ions by Persulfate

Меньшиков¹,

Белозерова²,

Остроушко³

2020

Physical and Chemical Aspects of the Study of Clusters, Nanostructures and Nanomaterials

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Изучены каталитические свойства нанокластерного железомолибденового полиоксометаллата {MoFe} в растворах при реализации окисления персульфатом йодид-ионов. Использована автоматизированная установка на базе спектрофотометрического метода анализа, управляемая компьютером. Сравнение литературных данных и кинетических данных окисления иодида персульфатом показывает, что кеплерат является гетерогенным катализатором. Эти данные позволяют предполагать нерадикальный механизм для разложения персульфата на поверхности молекул кластера на первой стадии реакции окисления иодида калия. Значение эффективной энергии активации процесса указывает на каталитическое воздействие {MoFe} на промежуточной стадии разложения пероксида водорода. Catalytic properties of the nanocluster iron-molybdenum polyoxometalate {MoFe} in solutions during the oxidation of iodide ions by persulfate have been studied. Automated installation based on spectrophotometric method of analysis controlled by computer was used. Comparison of literary data and kinetic datа on the oxidation of iodide with persulfate showed that keplerate {MoFe} is a heterogeneous catalyst. These data allowed to assume a non-radical mechanism for persulfate decomposition on the surface of cluster molecules at the first stage of the potassium iodide oxidation reaction. The value of the effective activation energy of the process indicates the catalytic effect of {MoFe} at the intermediate stage of the decomposition of the hydrogen peroxide.

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The physicochemical properties and influence on living organisms of nanocluster polyoxomolybdates as prospective bioinspired substances (based on materials from the plenary lecture)

Cited by 18 publications

References 35 publications

Fundamental Aspects of Xanthene Dye Aggregation on the Surfaces of Nanocluster Polyoxometalates: H‐ to J‐Aggregate Switching

Fundamental Aspects of Xanthene Dye Aggregation on the Surfaces of Nanocluster Polyoxometalates: H‐ to J‐Aggregate Switching

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Influence of the Nanocluster {Mofe} Polyoxometalate on Oxidation of Iodide-Ions by Persulfate

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