Influence of multidrug resistant organisms on the outcome of diabetic foot infection

Saltoğlu, Neşe; Ergönül, Önder; Tülek, Necla; Yemişen, Mücahit; Kadanalı, Ayten; Karagöz, Gül; Batırel, Ayşe; Ak, Öznur; Sonmezer, Cagla; Eraksoy, Haluk; Çağatay, Atahan; Sürme, Serkan; Nemli, Salih Atakan; Demırdal, Tuna; Çoşkun, Ömer; Öztürk, Derya; Ceran, Nurgül; Pehlivanoğlu, Filiz; Şengöz, Gönül; Aslan, Turan; Akkoyunlu, Yasemin; Öncül, Oral; Ay, Hakan; Mülazımoğlu, Lütfiye; Erturk, Buket; Yilmaz, Fatma; Yörük, Gülşen; Uzun, Nuray; Şimşek, Funda; Yıldırmak, Taner; Yaşar, Kadriye Kart; Sönmezoğlu, Meral; Küçükardalı, Yaşar; Tuna, Nazan; Karabay, Oğuz; Özgüneş, Nail; Sargın, Fatma

doi:10.1016/j.ijid.2018.02.013

Cited by 77 publications

(68 citation statements)

References 33 publications

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“…In accordance to our study, Konar & Das, Saseedharan et al and Saltoglu et al reported 36.84%, 23.7% & 31% MRSA isolates, respectively [10,11,19]. However, Bansal et al and Otta et al observed 55.56% and 77.8 %MRSA isolates in their study which is high in comparison to our study [6,9].…”

Section: Discussionsupporting

confidence: 88%

“…They observed Pseudomonas aeruginosa (21.67%) to be predominant followed by Staphylococcus aureus (18.88%), Escherichia coli (18.18%) and Klebsiella pneumoniae (16.78%). [6] However, Otta et al and Saltoglu et al reported Staphylococcus aureus (30%, 20%) to be the predominant isolate followed by Pseudomonas aeruginosa (11.7%, 19%) and Escherichia coli (10%, 12%) [9,19] In contrast, Konar and Das reported Pseudomonas aeruginosa (31.34%) as the most commonly isolated organism followed by Escherichia coli (23.8%) and Staphylococcus aureus (22.4%) [10]. This is similar to the findings by Shanmugam et al who reported Pseudomonas spp (16%) followed by Escherichia coli (14.6%) [15].…”

Section: Discussionmentioning

confidence: 99%

“…Among Enterobacteriaceaee, we found 100% ESBL producing strains which is in contrast with other studies. Otta et al Konar & Das, Shanmugam et al and Saltoglu et al isolated 42.1%, 46%, 37.5%, 38% ESBL producers, respectively [9,10,15,19].…”

Section: Discussionmentioning

confidence: 99%

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Microbiological Profile of Diabetic Foot Infections in a Tertiary Care Hospital in Navi Mumbai

Khan¹,

Joshi²,

Chowdhary³

2020

SJAMS

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Original Research Article Diabetic foot ulcers are most common serious consequences of diabetes. The proper management of diabetic foot infection (DFI) requires a detailed knowledge about the microbial spectrum and their antibiogram. In this study, 123 cases with DFI were studied. Pus swabs and deep tissue/ bone samples were collected. We observed 74.8% & 16.2% cases were monomicrobial and polymicrobial in nature, respectively. Pseudomonas aeruginosa (29.5%) was the most commonly isolated organism followed by Staphylococcus aureus (16.6%) and Escherichia coli (12.8%). We observed 27.27% strains of Methicillin Resistant Staphylococcus aureus (MRSA) & 100% Extended Spectrum Beta Lactamases (ESBLs) strains of enterobacteriacae. All the gram positive organisms, Staphylococcus aureus, Enterococcus faecalis and Coagulase negative Staphylococcus were sensitive to vancomycin (100%) and Linezolid (100%). Pseudomonas aeruginosa isolates were 100% sensitive to Amikacin and Tobramicin, Piperacillin-Tazobactm and Ciprofloxacin. Klebsiella pneumoniae showed high resistance to Cefepime (87.5%) and Piperacillin-Tazobactm (75%). Escherichea coli isolate showed 100% sensitivity towards Gentamicin. Acinetobacter baumanni showed 100% sensitivity for Imipenem and Meropenem.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Microbiological Profile of Diabetic Foot Infections in a Tertiary Care Hospital in Navi Mumbai

Khan¹,

Joshi²,

Chowdhary³

2020

SJAMS

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“…The most common bacterial isolates from diabetic ulcers in this study were Staphylococci species 40.8% compatible to other findings showed that Staphylococci species accounted 43.37%[23], whereas Gram negative bacteria were the most frequently pathogenic agents reported in other studies 51%[24], 56.1%[25], 61%[26], 67%[27] and 51.2%[28].Interestingly, our study revealed high rate of S. aureus 14.3%, S. epidermidis 14.3%, S. saprophyticus 9.5% and MRSA 4.8%. These results were compatible with the findings of other studies showed that S. aureus 19.4%, S. epidermidis 18.4% and other Staphylococci species 3.6%[29], Other study showed the most commonly isolated S. aureus 30%, followed by S. saprophyticus 19% and S. epidermidis 10%[30].…”

supporting

confidence: 91%

Assessment role of phagocytic neutrophil cells among different Wagner’s grades of diabetic foot ulcers infections

Bin-Hameed¹,

Baras²

2020

Preprint

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Background: Foot ulcers complications in diabetes mellitus (DM) patients are one of the significant medical problems and an economic burden. The aim of this study is to assessment role of phagocytic neutrophil cells and its relationship with the incidence of diabetic foot ulcers (DFU) infection of diabetic patients. A total of 60 venipuncture blood samples collected from diabetes mellitus, diabetic foot ulcer patients and healthy persons as control group. 20 swabs from the DFU patients were collected and processed for culture and susceptibility test after the ulcers classified according to Wagner’s grades system. Phagocytic cells activity test was performed to determine the efficiency of phagocytic neutrophil cells in diabetic patients. Results: Gram positive bacteria were the most prevalent in the DFU patients 57.1% with statistical significant relationship between the type of bacteria and grades of Wagner’s classification followed by Gram negative bacteria in high grades of ulcers. Wagner’s ulcers grade 1 and 2 were the most prevalence in DFU patients 30%. There was a weak negative correlation between the efficiency of phagocytic neutrophil cells activity and grade ulcers classified (r = -0.323). Amikacin and ciprofloxacin were the most effective antibiotics against 90.5% and 81% of the bacterial isolates respectively, whereas ampicillin, cefepime and cefadroxil were less effective antibiotics against the bacterial isolates.Conclusion: When the grade of ulcer increased, the bacterial resistance to antibiotics increased, and this was emphasis the correlation with prevalent of Gram negative bacteria in the high grade of ulcers with high resistance of antibiotics. In contrast, the grade of ulcer increased, the efficiency of phagocytic neutrophil cells decreased.

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“…Although age-related immunosenescence may be associated with infection-related mortality, it is also associated with diseases such as diabetes mellitus and chronic kidney disease (22,23). Moreover, there may be a difference between biological age and chronological age.…”

Section: Accepted Manuscript Discussionmentioning

confidence: 99%

Advanced Age is not a Risk Factor for Mortality in Patients with Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Organisms: a Multicenter Cohort Study

Mitsuboshi

Tsuruma

Watanabe³

et al. 2020

Jpn J Infect Dis

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A 5-year multicenter retrospective cohort study was conducted across six hospitals in Niigata, Japan. Patients (n = 179) with bacteremia due to ESBL-producing organisms were included in the study. The rate of appropriate carbapenem prescription was 41 (61%) in patients aged 65-84 years and 31 (89%) in those aged ≥85 years; patients aged ≥85 years were significantly more like to receive a carbapenem than their younger counterparts. After propensity score matching, 65 patients were assigned to two groups based on age (65-84 years or ≥85 years). Multivariate regression analysis showed that other sites of infection had a positive association with 30-day mortality (odds ratio [OR] 27.50, 95% confidence interval [CI] 2.90-260.00) and biliary tract infection tended to have a positive association with 30-day mortality (OR 8.90, 95% CI 0.88-89.90) compared with urinary tract infection. However, age ≥85 years was not associated with 30-day mortality. Elderly patients aged ≥85 years were more likely to be treated with carbapenem; however, being elderly was not associated with 30-day mortality when bacteremia was caused by ESBL-producing organisms. These results may help clinicians justify withholding carbapenem in patients over 85 years of age.

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Influence of multidrug resistant organisms on the outcome of diabetic foot infection

Abstract: Among rehospitalized patients, methicillin resistant Staphylococcus infections was detected as the most common agent, and Klebsiella spp. infections were found to be significantly associated with fatality.

Cited by 77 publications

References 33 publications

Microbiological Profile of Diabetic Foot Infections in a Tertiary Care Hospital in Navi Mumbai

Microbiological Profile of Diabetic Foot Infections in a Tertiary Care Hospital in Navi Mumbai

Assessment role of phagocytic neutrophil cells among different Wagner’s grades of diabetic foot ulcers infections

Advanced Age is not a Risk Factor for Mortality in Patients with Bacteremia Caused by Extended-Spectrum β-Lactamase-Producing Organisms: a Multicenter Cohort Study

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