Influence of moderate physical load on parameters of the immune system among residents of contaminated areas

Sokolenko, V. L.; Sokolenko, S. V.

doi:10.15421/021609

Cited by 5 publications

(2 citation statements)

References 16 publications

(18 reference statements)

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“…A recognized primary biomarker of allostatic loading is cortisol (Seeman et al, 1997). All examined students from the experimental group had an increased cortisol level (at the limit of homeostatic norm), then the indicator showed further increase during additional emotional load and exceeded 850 nmol/L (Sokolenko & Sokolenko, 2015;Sokolenko & Sokolenko, 2016).…”

Section: Discussionmentioning

confidence: 97%

Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

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We studied the features of allostatic load (AL) in 100 students aged 18–24 years old who, from birth to adulthood, lived in the territories assigned to the IV radiation zone after the Chornobyl accident (density of soil contamination by isotopes 137Cs 3.7–18.5∙104 Bq/m2) and underwent prolonged exposure to small doses of ionizing radiation. The examined students did not have any clinical signs of the immune-neuroendocrine system dysfunction. 50 people had signs of vegetative-vascular dystonia syndrome (VVD), 48 had signs of moderate hyperthyroidism and 21 had signs of moderate hypothyroidism. During the examination session, as a factor of additional psycho-emotional load, in 66 of the examined the immunoregulatory index CD4+/CD8+ went below the lower limit of the homeostatic norm, in 62 of the examined low density lipoprotein cholesterol (LDL-C) exceeded the upper level. The relative risk (RR) and attributable risk (AR) of the participation of potential secondary factors of allostatic load formation in CD4+/CD8+ immunoregulatory index going below the lower limit were calculated. The presence of statistically significant relative risk of participation in the formation of suppression of the index CD4+/CD8+: the state of hyperthyroidism, state of hypothyroidism, vegetative-vascular dystonia syndrome, higher than normal LDL-C. When the examined students combined the signs of hyperthyroidism, vegetative-vascular dystonia syndrome and higher level of LDL-C; with combination of signs of hypothyroidism, vegetative-vascular dystonia syndrome and higher level of LDL-C. The attributable risk in all cases exceeded 0.10, which confirmed the importance of some of these factors and their complexes in the formation of the effect of reduced immunoregulatory index. The CD4+/CD8+ index can be considered an important biomarker of AL and premature age-related changes in the immune system in residents of radiation-contaminated areas. The risk of AL formation in the case of occurrence of a complex of mediated secondary biomarkers (vegetative-vascular dystonia syndrome, thyroid dysfunction, hypercholesterolemia) is higher compared to their individual significance.

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Section: Discussionmentioning

confidence: 97%

Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

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“…These include hypoxia of different genesis, hypokinesia, radiation, physical, and mental overload, and stress. [1] Their impact depletes energy potential and the defenses of the human body, manifesting in rapid onset of fatigue, and reduced efficiency. As a result, one may experience different psychosomatic diseases, a typical manifestation of which is chronic fatigue syndrome, accompanied by a significant decrease in efficiency of human organism.…”

Section: Introductionmentioning

confidence: 99%

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Kryvoviaz

2017

AJP

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Aim: To study the effect of 5-R-thio-tetrazolo[1,5-с]quinazoline derivatives on the physical performance in different types of physical exercise. Materials and Methods: The experiments were performed on Wistar white male rats weighing 190-210 g. The investigated substances and a comparator, 2-ethylthiobenzymidazol hydrobromide, were injected intraperitoneally to animals OD during 5 days in ED 50 doses. Physical performance of rats was assessed by treadmill running tests at a speed of 42 m/min with a 10° slope angle and holding rats at a 15 rpm rotarod test. The study was performed on the day 5 of the experiment, 40 min after the past injection. Results and Discussion: We revealed that a 5-day course administration of 5-R-thio-tetrazolo[1,5-c]quinazoline derivatives at an ED 50 dose contributed to growing the length of a rat treadmill running. The results of the test presented that physical endurance of animals grew with compounds KB-10, KB-28, KB-51, and KB-55 by 47.1, 60.7, 32.3, and 46.0 %, respectively. The duration of holding rats on rotarods with a pharmacological correction was 41.2-71.4 % higher than in the control group. The dynamics of physical endurance against treadmill running and rotarod tests results in the group of animals administered the reference medicine, 2-ethylthiobenzymidazol hydrobromide, made up 50.7 and 59.4% compared to the control, respectively. Conclusion: KB-28 (sodium 2-(tetrazolo[1,5-c]quinazoline-5-iltio)acetate) demonstrated the greatest effect on physical endurance of study participants among all 5-R-thio-tetrazolo[1,5-c]quinazoline derivatives. This substance was not only similar with the reference medicine in efficacy but also had ED 50 19 times lower than reference actoprotector.

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Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

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We have studied the interdependence of the intensity of oxidative processes/antioxidant level and the thyroid status parameters in a group of students aged 18–24 who lived for a long time in the territory of enhanced radioecological control (density of soil contamination by isotopes (137Cs 3.7 ∙ 104 – 18.5 ∙ 104 Bq/m2). We examined 50 people from relatively environmentally friendly areas (control group) and 50 people from IV radiation zone (experimental group). In the experimental group, there were no individuals with clinical manifestations of thyroid pathology. However, subgroups with signs of hyperthyroidism and hypothyroidism were identified. We evaluated the level of cortisol, thyrotrophic hormone (TSH), triiodothyronine (T3), thyroxine (T4), malonic dialdehyde (MDA), ceruloplasmin (CP), transferrin (Tf), sulfhydryl groups (SH); we calculated the oxidative stress index (OSI). The research was conducted one month before the examination time and also during the exams as a factor in increased emotional stress. A lowered CP level was found in the subgroup with signs of hypothyroidism; SH groups – in all subgroups, separated by thyroid status. The oxidative stress index was higher in all students examined of the experimental group, compared with the control. The growth of MDA level is marked in the experimental group – it is the most strongly pronounced in conditions of additional emotional load in people with signs of hyperthyroidism and hypothyroidism. CP level significantly decreased in the subgroup of hyperthyroidism on the background of T3 decrease. OSI increased in all students examined from the experimental group. In the subgroup of hypothyroidism it became significantly higher than in the subgroup of euthyroidism. A positive correlation between the levels of CP and T3 was found. The highest values of the correlation coefficients were noted for subgroups with signs of hyperthyroidism and hypothyroidism, with the coefficient significance increasing under conditions of emotional stress. The index of oxidative stress in the experimental group positively correlated with the level of TSH – in terms of emotional stress, the statistical significance of the coefficients disappeared. In the subgroups divided by thyroid status, variability of interactions between OSI and T3 was observed but it was not statistically significant. It was found that the participation of thyroid status in supporting redox homeostasis in people aged 18–24 who suffered from chronic small-doze radiation exposure was realized mainly by the influence on the antioxidant system. The ability of thyroid hormones to maintain a proper antioxidant state was suppressed in this group. The unbalanced relationship between thyroid hormones and oxidative stress indicators is strongly manifested under conditions of additional emotional stress.

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Influence of moderate physical load on parameters of the immune system among residents of contaminated areas

Cited by 5 publications

References 16 publications

Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years

Manifestations of allostatic load in residents of radiation contaminated areas aged 18–24 years

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Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

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