Influence of microporosity and macroporosity on the mechanical properties of biphasic calcium phosphate bioceramics: Modelling and experiment

Pecqueux, Franc ̧ois; Tancret, Franck; Payraudeau, Nathalie; Bouler, Jean‐Michel

doi:10.1016/j.jeurceramsoc.2009.09.017

“…Since calcium orthophosphates are either thermally unstable (MCPM, MCPA, DCPA, DCPD, OCP, ACP, CDHA) or have a melting point at temperatures exceeding ~ 1400 °C with a partial decomposition (α-TCP, β-TCP, HA, FA, TTCP), only the first and the second consolidation approaches are used to prepare bulk bioceramics and scaffolds. The methods include uniaxial compaction [198,199], isostatic pressing (cold or hot) [200][201][202][203][204][205][206], granulation [207,208], loose packing [209], slip casting [210][211][212][213], gel casting [188,189,[214][215][216][217][218][219], pressure mold forming [220], injection molding [221], polymer replication [222][223][224][225], extrusion [226][227][228], slurry dipping and spraying [229], as well as to form ceramic sheets from slurries tape casting [124,216,230,231] doctor blade [232] and colander methods might be employed [194][195][196][197]…”

Section: Forming and Shapingmentioning

confidence: 99%

“…In general, the mechanical properties decrease significantly with increasing content of an amorphous phase, microporosity and grain sizes, while a high crystallinity, a low porosity and small grain sizes tend to give a higher stiffness, a higher compressive and tensile strength and a greater fracture toughness. Accordingly, from the mechanical point of view, calcium orthophosphate bioceramics appear to be brittle polycrystalline materials for which the mechanical properties are governed by crystallinity, grain size, grain boundaries, porosity and composition [203]. Thus, it possesses poor mechanical properties (for instance, a low impact and fracture resistances) that do not allow calcium orthophosphate bioceramics to be used in loadbearing areas, such as artificial teeth or bones [49][50][51][52][53][54][55]300] ).…”

Section: Sintering and Firingmentioning

confidence: 99%

“…It is also worth mentioning that porous HA bioceramics is considerably less fatigue [306] resistant than dense ones. Both grain sizes and porosity are reported to influence the fracture path, which itself has a little effect on the fracture toughness of calcium orthophosphate bioceramics [203,307]. Furthermore, no obvious decrease in mechanical properties was found after calcium orthophosphate bioceramics had been aged in the various solutions during the different time periods [308].…”

Section: Sintering and Firingmentioning

confidence: 99%

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Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…Since calcium orthophosphates are either thermally unstable (MCPM, MCPA, DCPA, DCPD, OCP, ACP, CDHA) or have a melting point at temperatures exceeding ~ 1400 °C with a partial decomposition (α-TCP, β-TCP, HA, FA, TTCP), only the first and the second consolidation approaches are used to prepare bulk bioceramics and scaffolds. The methods include uniaxial compaction [198,199], isostatic pressing (cold or hot) [200][201][202][203][204][205][206], granulation [207,208], loose packing [209], slip casting [210][211][212][213], gel casting [188,189,[214][215][216][217][218][219], pressure mold forming [220], injection molding [221], polymer replication [222][223][224][225], extrusion [226][227][228], slurry dipping and spraying [229], as well as to form ceramic sheets from slurries tape casting [124,216,230,231] doctor blade [232] and colander methods might be employed [194][195][196][197]…”

Section: Forming and Shapingmentioning

confidence: 99%

Untitled

2011

BIO

0

View full text Add to dashboard Cite

In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…[24,25] Different strategies were tested to fortify the characteristics of ceramics. [26,27] A myriad of methods has been reported to prepare nanostructured CAP, and various morphologies including nanoparticles, plate-like nanocrystals, nanoneedles, nanotubes, and nanoblades. [28] Solubility is one of the important parameter to achieve the desired concentration of drug in systemic circulation for pharmacological response to be shown.…”

Section: Introductionmentioning

confidence: 99%

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Vengala¹

2017

AJP

0

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Introduction: To enhance the delivery of poorly-soluble drugs, we have explored aquasomes (three-layered, ceramic core based, and oligosaccharide-coated nanoparticles) as potential carriers for the delivery of model hydrophobic drug lornoxicam (log P = 3.15). Materials and Methods: Ceramic nanoparticles were prepared using coprecipitation by sonication method. Cellobiose was used for coating onto ceramic core followed by loading of the lornoxicam by partial adsorption mechanism. The prepared system was characterized for size, shape, drug loading efficiency, and in vitro release profile (both 0.1 N hydrochloric acid solution and phosphate buffer solution, pH 6.8). Colorimetric analysis of sugar coating was done using phenol sulfuric acid method. Results and Discussion: The formed particles were spherical with an average particle size in the range of 60-300 nm, with a media of 87 nm. The in vitro dissolution performance was compared with that of pure drug and better results were observed. The cumulative lornoxicam release for the aquasome formulation (49%) was found to be higher than that of pure drug (34%) and was found to be gradual and linear in acidic media. Whereas, in phosphate buffer solution, pH 6.8, an incomplete release was observed with the pure drug (51% in 2 h) and 95% release was observed within 90 min from the formulation. Conclusion: Ceramic nanoparticles can be used for the enhancement of dissolution profile of poorly soluble drugs.

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Influence of microporosity and macroporosity on the mechanical properties of biphasic calcium phosphate bioceramics: Modelling and experiment

Cited by 80 publications

References 49 publications

Medical Application of Calcium Orthophosphate Bioceramics

Medical Application of Calcium Orthophosphate Bioceramics

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