Influence of microphysical structure on in vitro activity of new synthetic antacids

Bulk Crystals to Surfaces: Combining X-ray Diffraction and Atomic Force Microscopy to Probe the Structure and Formation of Crystal Interfaces

“…The orientation and packing density of the MBSA anions deduced from the AFM data were consistent with previously reported X-ray diffraction data obtained for HT intercalated with these anions, in which the less densely packed MBSA 2- layers can interdigitate to afford as interlayer spacing of 13 Å whereas the densely packed MBSA 1- layers cannot interdigitate, resulting in an interlayer spacing of 21 Å. This example demonstrates that the structure of reversibly adsorbed, organized layers of molecules can be characterized in situ by AFM, providing surface stoichiometry and adlayer symmetry and even insight into ordering in a bulk solid that is not attainable by standard diffraction techniques.…”

“…This was demonstrated in our laboratory for the formation of organized adlayers of molecular anions on the (0001) surface of hydrotalcite (HT), a layered clay with the composition Mg 6 Al 2 (OH) 16 CO 3 ·4H 2 O. This adsorption process was believed to mimic the ion exchange reactions that commonly occur within the layers of hydrotalcite and other layered clays, which have significant technological interest due to their utility as ion-exchange materials, catalysts, antacids, and catalytic supports…”

Influence of the Fractal Character of Model Substances on their Reactivity at Solid–Liquid Interfaces

“…In this work, the D of some selected antacids was measured with their velocity of acid neutralization. Also, other physical properties, such as the specific surface area, particle size and size distribution, and porosity, which can also affect surface reactivity (20,21), were studied. Thus, the identification of predominating factors which affect reactions at interfaces between solid and bulk liquid was possible.…”