Influence of microcrystalline cellulose source and batch variation on the tabletting behaviour and stability of prednisone formulations

Landín, Mariana; Martínez‐Pacheco, Ramón; Gómez-Amoza, J.L.; Souto, C.; Concheiro, Angel; Rowe, R.C.

doi:10.1016/0378-5173(93)90333-b

Cited by 33 publications

(19 citation statements)

References 9 publications

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“…Several studies have compared microcrystalline cellulose with various sources, including different manufacturers and different sites [4,[43][44][45][46][47]. MCC produced by various manufacturers or in various manufacturing sites may have different properties due to the kinds of pulp used as raw materials and their respective manufacturing conditions [2,4].…”

Section: Synthesis Of MCCmentioning

confidence: 99%

Microcrystalline Cellulose as Pharmaceutical Excipient

Chaerunisaa¹,

Sriwidodo²,

Abdassah³

2020

Pharmaceutical Formulation Design - Recent Practices

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Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from α-cellulose precursor (type Iβ), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. It is commonly manufactured by spray-drying the neutralized aqueous slurry of hydrolyzed cellulose. The MCC is a valuable additive in pharmaceutical, food, cosmetic, and other industries. MMC obtained from different sources will differ considerably in chemical composition, structural organization, and physicochemical properties (crystallinity, moisture content, surface area and porous structure, molecular weight, etc.). The high demand of microcrystalline cellulose used in pharmaceutical industries has led to the utilization of locally and naturally occurring materials in the production of microcrystalline cellulose. Many studies on the physicochemical properties of locally produced MCC derived from natural sources have been extensively evaluated in the development of a new natural source for MCC as a substitution of wood, the most abundant one.

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Section: Synthesis Of MCCmentioning

confidence: 99%

Microcrystalline Cellulose as Pharmaceutical Excipient

Chaerunisaa¹,

Sriwidodo²,

Abdassah³

2020

Pharmaceutical Formulation Design - Recent Practices

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“…Between the suggested applications to recycle agricultural waste MCC was prepared and used for some pharmaceutical applications (El-Sakhawy and Hassan, 2007). MCC has binding properties which held the components of the pharmaceutical tablets together upon compressing (El-Sakhawy and Hassan, 2007;Landín et al, 1993;Westermarck et al, 1999). It was prepared in an easy way from cellulose pulps using diluted acids and present in markets as a commercial product (El-Sakhawy and Hassan, 2007).…”

Section: Introductionmentioning

confidence: 99%

Microcrystalline cellulose as a reinforcement agent to cement pastes

Mohammed

Ahmed

Osman

2014

Pigment &Amp; Resin Technology

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Purpose -A try to find some useful applications for some products prepared from agricultural waste by mixing them with cement to act as reinforcement agents. The paper aims to discuss these issues. Design/methodology/approach -Cement was mixed with microcrystalline cellulosic (MCC) fibres prepared from baggase, soaked in mixing water, followed by cubic pastes formation. The mixing was performed using different ratios of MCC; 0.5, 0.75, 1 and 3 per cent. The cement properties were followed at timed intervals, up to 90 days. The initial and final setting times of the pastes were determined. Bulk density, apparent porosity and compressive strength of the harden cement pastes were also identified. The hydration kinetic was followed by identifying free lime ratio and chemically combined water content. The structure of the hard cement pastes was followed by SEM, FTIR, DSC and XRD. Findings -It was noticed that the weight of the prepared cement pastes using MCC was reduced, while the compressive strength was increased. In addition, lower ratios of MCC have shown better results at early ages of hydration and reported higher compressive strength than control. No interaction was reported between the fibres and cement constituents based on the performed analysis. Research limitations/implications -Different types of agricultural wastes can be compared in producing the best type of MCC for the same purpose of this research. Practical implications -This piece of work has suggested a simple way to convert a product prepared from agricultural wastes in a small uniform size to a reinforcement agent to cement. Consuming this type of waste reduces the risks resulting from its burning at some countries such as Egypt. Originality/value -MCC fibres have well-known binding properties and used successfully on wide range in medical applications for tablets production with low costs. These fibres have reduced the pastes weight and increased the compressive strength using low ratios of them. Moreover, there is no indication of a reaction between these fibres and cement constituents.

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“…Published reports have underscored the effect of interand intra-manufacturer variability in excipient properties on processability, quality, and performance of the finished drug product (3,4). Polymeric excipients, in particular, comprise mixtures of polymers of different molecular weights and chemical composition and tend, as a result, to exhibit more variability than other excipients.…”

Section: Introductionmentioning

confidence: 99%

Inter- and Intra-Manufacturer Variability in Pharmaceutical Grades and Lots of Xanthan Gum

et al. 2010

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Abstract. A pharmaceutical formulation typically contains one or more excipients in addition to the active pharmaceutical ingredient(s). Though excipients have been considered inert components of a formulation, variability in their properties has been shown to affect the performance of drug dosage forms and delivery systems. This study investigates the inter-and intra-manufacturer variability among different NF grades and lots of xanthan gum made by two manufacturers. As many formulators rely on compendial standards to monitor and control the variability of excipients, this study focuses on the adequacy of the NF specifications, in particular the viscosity specification, to discern the variability in solution properties of different pharmaceutical grades and lots of xanthan gum. All the grades and lots in this study were NF grade materials. Xanthan gum solutions were prepared in accordance with NF test methodology and were rheologically evaluated using a rotational rheometer. Both steady shear measurements and small amplitude oscillatory measurements were carried out on 1% w/w xanthan gum solutions. Results showed significant inter-and intra-manufacturer variability among the NF grades and lots of xanthan gum that was not reflected in the NF viscosity test specifications.

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Influence of microcrystalline cellulose source and batch variation on the tabletting behaviour and stability of prednisone formulations

Cited by 33 publications

References 9 publications

Microcrystalline Cellulose as Pharmaceutical Excipient

Microcrystalline Cellulose as Pharmaceutical Excipient

Microcrystalline cellulose as a reinforcement agent to cement pastes

Inter- and Intra-Manufacturer Variability in Pharmaceutical Grades and Lots of Xanthan Gum

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