Influence of Mg doping on the early steps of physico-chemical reactivity of sol–gel derived bioactive glasses in biological medium

Abstract

The aim of this study is to highlight the influence of magnesium doping on the surface reactivity of binary (SiO(2)-CaO) and ternary (SiO(2)-CaO-P(2)O(5)) bioactive glasses, prepared by sol-gel chemistry, in biological conditions. These materials were produced in powder form, and their compositional and textural properties characterized. They were then soaked in biological fluids for different delays from 0 to 4 days. The surface changes were characterized using Particles Induced X-ray Emission (PIXE) associated with Rutherford Backscattering Spectroscopy (RBS), which are efficient methods for multi-elemental analysis. Elemental maps of major and trace elements were obtained at a micrometer scale and revealed the formation of a calcium phosphate-rich layer after a few days of interaction. We demonstrate that the presence of magnesium in the material has an impact on the development and the formation rate of the bone-like apatite layer.

Reprint of: Review of bioactive glass: From Hench to hybrids

“…When phosphate is present (usually using the precursor triethylphosphate) in a silica sol-gel glass, it is present as orthophosphate, as it is in the melt-derived glasses [152]. Replacing calcium with magnesium can also reduce the dissolution rate of the glass and therefore its bioactivity, perhaps due to the magnesium behaving as a network intermediate [153][154][155].…”

Bioactive glasses and glass‐ceramics versus hydroxyapatite: Comparison of angiogenic potential and biological responsiveness

“…In fact, it was previously reported in the literature that Sr (Fernandes et al, ; Isaac et al, ; Lao et al, ; Massera, Kokkari, Narhi, & Hupa, ; Santociledes‐Romero et al, ; Simon, Rawlinson, Hill, & Fortune, ) and Mg (Moghanian, Sedghi, Ghorbanoghli, & Salari, ; Saboori et al, ; Soulié, Nedelec, & Jallot, ; Watts, Hill, O'Donnell, & Law, ) might have a beneficial effect in terms of biological properties.…”

Magnesium‐Containing Bioactive Glasses for Biomedical Applications

“…A number of studies demonstrated that divalent cations such as Mg 2+ play a critical role in bone remodeling and skeletal tissue development . Furthermore, Mg 2+ is also one of the most important divalent ions associated with biological apatites (bone consists of 0.47 wt% Mg and dentin 1.11 wt% Mg) . Moreover, researches have shown that in calcified tissues, magnesium is involved in the calcification process and there is growing evidence that Mg may improve bone mineral density and affect bone fragility .…”