Influence of Mechanical Stress on Palmoplantar Erythrodysesthesia - a Case Report

Abstract

Background: Cutaneous adverse events can have an important negative influence on quality of life and compliance in affected patients. Palmoplantar erythrodysesthesia (PPE; hand-foot syndrome) is a cutaneous toxicity associated with chemotherapeutic treatment, which necessitates treatment interruption or dose reduction in severe cases. This case report of pegylated liposomal doxorubicin-induced PPE shows the influence of mechanical stress on the development of skin lesions in various locations and the importance of patient education and compliance. Case Report: We present the case of a 43-year-old female patient diagnosed with ovarian cancer and having undergone surgical and chemotherapeutic treatment. The development of extensive grade 3 PPE affecting numerous areas of the body particularly exposed to mechanical pressure necessitated dermatological treatment. The combination of local application of an antioxidant-containing ointment and the patient's compliance made it possible to continue chemotherapy without interruption or dose reduction. Conclusion: The development of PPE often limits the use of chemotherapeutic agents, and this case report can provide a possible therapeutic and preventive strategy for affected patients.

Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors

“…Nevertheless, it is assumed that the decrease in sweating leads to a lower volume of the sweat secreted with a higher density of the chemotherapeutic agent (unpublished data). Another reason for the appearance of PPE on palmar-plantar skin sites might be the mechanical friction and pressure that might cause vascular microtrauma and enhance the inflammatory response and tissue damage combined with the local toxic effect of the chemotherapy [ 239 ].…”

Identificação, Prevenção e Tratamento da Síndrome Mão-Pé Induzida por Quimioterapia: Revisão Sistemática

“…A síndrome mão-pé é uma reação adversa muito comum durante o tratamento com agentes quimioterápicos e é um fator preditor de morbidade e mortalidade, uma vez que as lesões são portas de entrada para instalação de microrganismos e, dessa forma, implica em risco de sepse [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] .…”

Liposomal doxorubicin-related palmar–plantar erythrodysesthesia (hand–foot syndrome): a case report

“…The incidence of HFS caused by liposomal doxorubicin is relatively low, but the symptoms are obvious and easily cause patients physiological and psychological discomfort. 1 , 2 The purpose of this paper was to raise clinical awareness of the adverse events related to liposomal doxorubicin injection, and to provide new ideas for the clinical treatment of these adverse events.…”