Influence of maternally-derived antibodies on live attenuated influenza vaccine efficacy in pigs

Pyo, Hyun Mi; Hlasny, Magda; Zhou, Yan

doi:10.1016/j.vaccine.2015.06.044

Cited by 13 publications

(13 citation statements)

References 35 publications

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“…Maternal antibodies play an important role in the neonatal protection of piglets from infectious agents in the immediate postnatal days before they can develop robust immunities of their own. The vaccination status of the sow and immune difference between sows influence the level of colostrum IgG [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Supplementing Colostrum from Multiparous Sows: Effects on Performance and Health in Piglets from Gilts in Farm Conditions

Miguel

Mitjana

Tejedor

et al. 2021

Animals

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Gilts produce less colostrum with lower immunoglobulin G concentration than multiparous sows do. An extra dose of colostrum (30 mL) from multiparous sows was administered to piglets from gilts to ascertain its effects on performance and health in farm conditions, especially in the smallest piglets (birth weight < 1.100 kg; Q1). The control group (CON) consisted of 200 piglets from 18 gilts (50 smallest piglets) and 201 piglets from 16 gilts (52 smallest piglets) formed the supplemented group (SUP). Colostrum supplementation increased the homogeneity of weight (days 21 and 60) and average daily gain (ADG; days 0–10, 0–21, and 0–60) and a decreased use of antibiotics and mortality by diarrhoea (p < 0.05). SUP piglets showed better immune response (presence of antibodies, p = 0.033) against Mycoplasma hyopneumoniae (day 21), porcine reproductive and respiratory syndrome (PRRS; day 60), and influenza (day 60). In the smallest piglets, colostrum supplementation had important effects on mean weight in the first day of life (p = 0.009) and ADG until day 21 (p < 0.05). The smallest piglets had decreased the use of antibiotic treatment use when supplemented (p < 0.05). Colostrum supplementation can improve piglets´ performance and health, although doing so requires increased time and labour in maternity.

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Section: Discussionmentioning

confidence: 99%

Supplementing Colostrum from Multiparous Sows: Effects on Performance and Health in Piglets from Gilts in Farm Conditions

Miguel

Mitjana

Tejedor

et al. 2021

Animals

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“…However, those results should be carefully interpreted as the H3N2 challenge virus was also undetected in the lungs of 4 out of 5 pigs from the challenge control group. Those vaccines proved to protect in presence of MDAs and VAERD was never reported (129).…”

Section: Other Technologies Of Attenuationmentioning

confidence: 99%

Influenza A Virus in Swine: Epidemiology, Challenges and Vaccination Strategies

et al. 2020

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“…The left side of the lung was fixed with 10% natural buffered formalin, processed for hematoxylin and eosin (H&E) staining, and assessed in a blind manner by a board-certified veterinary pathologist as previously described [21].…”

Section: Methodsmentioning

confidence: 99%

In Vivo Characterization of Avian Influenza A (H5N1) and (H7N9) Viruses Isolated from Canadian Travelers

Landreth

Gaba

et al. 2019

Viruses

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Highly pathogenic avian influenza (HPAI) H5N1 and low pathogenic avian influenza (LPAI) H7N9 viruses pose a severe threat to public health through zoonotic infection, causing severe respiratory disease in humans. While HPAI H5N1 human infections have typically been reported in Asian countries, avian H7N9 human infections have been reported mainly in China. However, Canada reported a case of fatal human infection by the HPAI H5N1 virus in 2014, and two cases of human illness associated with avian H7N9 virus infection in 2015. While the genomes of the causative viruses A/Alberta/01/2014 (H5N1) (AB14 (H5N1)) and A/British Columbia/1/2015 (H7N9) (BC15 (H7N9)) are reported, the isolates had not been evaluated for their pathogenicity in animal models. In this study, we characterized the pathogenicity of AB14 (H5N1) and BC15 (H7N9) and found that both strain isolates are highly lethal in mice. AB14 (H5N1) caused systemic viral infection and erratic proinflammatory cytokine gene expression in different organs. In contrast, BC15 (H7N9) replicated efficiently only in the respiratory tract, and was a potent inducer for proinflammatory cytokine genes in the lungs. Our study provides experimental evidence to complement the specific human case reports and animal models for evaluating vaccine and antiviral candidates against potential influenza pandemics.

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Influence of maternally-derived antibodies on live attenuated influenza vaccine efficacy in pigs

Cited by 13 publications

References 35 publications

Supplementing Colostrum from Multiparous Sows: Effects on Performance and Health in Piglets from Gilts in Farm Conditions

Supplementing Colostrum from Multiparous Sows: Effects on Performance and Health in Piglets from Gilts in Farm Conditions

Influenza A Virus in Swine: Epidemiology, Challenges and Vaccination Strategies

In Vivo Characterization of Avian Influenza A (H5N1) and (H7N9) Viruses Isolated from Canadian Travelers

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