Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes

Moreli, Jusciéle Brogin; Morceli, Glilciane; Luca, Ana Karina C. De; Magalhães, Cláudia Garcia; Costa, Roberto Antônio de Araújo; Damasceno, Débora Cristina; Rudge, Marilza Vieira Cunha; Calderon, Iracema de Mattos Paranhos

doi:10.1007/s10875-011-9634-3

Cited by 27 publications

(24 citation statements)

References 25 publications

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“…After screening titles and abstracts, 31 references were selected for full-text reading [16][17][18][19][20][21][22][23][24][25][26][27][28][29][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] and 23 citations reporting on 22 studies were included in this review (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

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Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gomes

Torloni

Gueuvoghlanian-Silva

et al. 2013

American J Rep Immunol

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CitationGomes CP, Torloni MR, Gueuvoghlanian-Silva BY, Alexandre SM, Mattar R, Daher S. Cytokine levels in gestational diabetes mellitus: a systematic review of the literature. Am J Reprod Immunol 2013; 69: 545-557 doi:10.1111/aji.12088 Problem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of StudyThree electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. ResultsTwenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD = 0.45, 95% CI À0.34-1.23). ConclusionsNew studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM.

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Section: Resultsmentioning

confidence: 99%

“…Due to its anti-inflammatory properties, IL-10 has also been investigated in GDM and other hyperglycemic conditions 9,53,60 . Four studies included in this review reported lower concentration of IL-10 in patients with GDM compared with healthy pregnant women, as expected.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gomes

Torloni

Gueuvoghlanian-Silva

et al. 2013

American J Rep Immunol

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“…Despite increased synthesis, plasma cytokine levels may not be influenced due to the presence of various factors that prevent the transition of cytokines into the circulation. Among these factors, hypoxic environment due to hyperglycemia and pre-existing inflammatory conditions should be encountered [47]. According to our study, TNF-α appears to be associated more closely than other cytokines with poor glycemic control and oxidative stress parameters.…”

Section: Discussionmentioning

confidence: 61%

The Relation Of Oxidative Stress Biomarkers With Proinflammatory Cytokines In Gestational Diabetes

Genç¹,

Kusku-Kiraz²,

Dervisoglu³

et al. 2017

Clinical-Investigation

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Background: It has been shown that the synthesis and secretion of cytokines is influenced by the imbalance in oxidant/antioxidant status. In this study, the relation between the circulating levels of oxidative stress biomarkers and proinflammatory cytokines was searched in gestational diabetes mellitus (GDM) patients in order to evaluate the possible role of oxidative stress in ongoing proinflammatory condition and impaired glucose homeostasis.

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“…Despite the increase in placental TNF-α, its plasma levels may not alter due to the presence of various factors which is known to affect the transition of placental secretion through the circulation. Among these factors, hypoxia resulted from hyperglycemic environment and pre-existing inflammatory condition should be taken into account [34,35]. Previous studies with regard to IL-10 levels in GDM are not concordant [15,19,25,26,36].…”

Section: Discussionmentioning

confidence: 96%

The Association of Glycemic Markers with Plasma Adipocytokine Levels in Women with Gestational Diabetes

Öztop¹,

Kiraz²,

Dervisoglu³

2016

J Diabetes Metab

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Introduction: Alterations in the synthesis of cytokines have been demonstrated in gestational diabetes (GDM), but the association of cytokines with short-and long-term glycemic markers has not been defined clearly. In this study, the variations in the plasma levels of visfatin, TNF-α, IL-1β, IL-6, and IL-10 were investigated and theirassociations with glycemic markers -HbA1C, fructosamine, 1,5-anhydro-D-glucitol (1,5-AG), and continuous glucose monitoring system (CGMS) parameters were evaluated.

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Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes

Cited by 27 publications

References 25 publications

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

The Relation Of Oxidative Stress Biomarkers With Proinflammatory Cytokines In Gestational Diabetes

The Association of Glycemic Markers with Plasma Adipocytokine Levels in Women with Gestational Diabetes

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