Influence of manganese ions on cellular behavior of human osteoblasts in vitro

Lüthen, Frank; Bulnheim, Ulrike; Müller, Petra; Rychly, Joachim; Jesswein, Henrike; Nebe, J. G. Barbara

doi:10.1016/j.bioeng.2007.08.003

Cited by 68 publications

(41 citation statements)

References 7 publications

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“…While CT and ALP are known for osteogenesis, TRAP is a chemical secreted by osteoclasts that is partially responsible for creating an acidic environment that helps to break down the bone. While it may be surprising that both osteoclast and osteoblast activities are decreased, researchers have found that manganese is essential in the binding of integrins to ligands which is the mechanism by which cells bind to substrates [86]. In the case of osteoblasts and osteoclasts, the ability to bind to fibronectin and collagen in the extracellular matrix is disrupted.…”

Section: Tri-/tetravalent Cationsmentioning

confidence: 99%

Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Bose

Fielding

Tarafder

et al. 2013

Trends in Biotechnology

433

289

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The general trends in synthetic bone grafting materials are shifting towards approaches that can illicit osteoinductive properties. Pharmacologics and biologics have been used in combination with calcium phosphate (CaP) ceramics, however, recently have become the target of scrutiny over the safety. The importance of trace elements in natural bone health is well documented. Ions, e.g. lithium, zinc, magnesium, manganese, silicon, strontium etc. have shown to increase osteogenesis and neovascularization. Incorporation of dopants into CaPs can provide a platform for safe and efficient delivery in clinical applications where increased bone healing is favorable. This review highlights use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.

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Section: Tri-/tetravalent Cationsmentioning

confidence: 99%

Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Bose

Fielding

Tarafder

et al. 2013

Trends in Biotechnology

433

289

View full text Add to dashboard Cite

show abstract

“…These implant surface properties are reported in the literature to enhance bone bonding to implant surfaces and stimulate adjacent bone growth [14][15][16]. The released alloying elements or elements from the coating on magnesium implants could be another source to influence local bone cell response [13,17,18]. Furthermore, magnesium ions from the corroding magnesium implant and the accompanying local alkalosis could also contribute to the enhanced bone growth [19,20].…”

Section: Introductionmentioning

confidence: 96%

Magnesium hydroxide temporarily enhancing osteoblast activity and decreasing the osteoclast number in peri-implant bone remodelling☆

et al. 2010

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“…A study conducted by Rico et al [12] showed that when ovariectomized rats were supplemented with manganese, their bone density was remarkably higher than that of rats without supplementation. Lüthen et al [13] also reported that when they supplied manganese to human MG-63 osteoblastic cells, they could observe a decrease in alkaline phosphatase (ALP) and collagen I mRNA expression at >0.1 mM MnCl 2 . Considering these study results, our research focused on the effects of manganese supplements on osteoporosis and bone metabolism (e.g., bone density, bone formation, and resorption).…”

mentioning

confidence: 93%

Manganese Supplementation Improves Mineral Density of the Spine and Femur and Serum Osteocalcin in Rats

Bae

Kim

2008

Biol Trace Elem Res

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The effect of manganese (Mn) supplementation on bone mineral density (BMD) and bone metabolism parameters was determined in ovariectomized Sprague-Dawley rats. Rats were divided into four groups (OVX, OVX+Mn, sham, sham+Mn) and fed with different intake levels of manganese (adequate 0.001% Mn, supplementation 0.01% Mn) for 12 weeks. BMD of the lumbar vertebrae, femur, and tibia were significantly lowered in ovariectomized rats compared to the sham group. In addition, BMD of the lumbar vertebrae was significantly increased by Mn supplementation in the sham groups. Serum C-telopeptide cross-links of type I collagen (CTx), bone resorption biomarker, alkaline phosphatase (ALP), and bone formation biomarkers were not significantly different among the four groups. However, serum osteocalcin, a more sensitive bone formation biomarker, was significantly increased by Mn supplementation. To summarize, Mn supplementation resulted in increased BMD and bone formation. Based on our findings, more research is needed to better understand the effects of manganese supplementation on bone formation and resorption.

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Influence of manganese ions on cellular behavior of human osteoblasts in vitro

Cited by 68 publications

References 7 publications

Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Magnesium hydroxide temporarily enhancing osteoblast activity and decreasing the osteoclast number in peri-implant bone remodelling☆

Manganese Supplementation Improves Mineral Density of the Spine and Femur and Serum Osteocalcin in Rats

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