Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Bose, Susmita; Fielding, Gary; Tarafder, Solaiman; Bandyopadhyay, Amit

doi:10.1016/j.tibtech.2013.06.005

Cited by 435 publications

(316 citation statements)

References 101 publications

(120 reference statements)

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“…46,47 Given the functions of Si and Mg ions, the incorporation of m-MS into PBSu scaffolds could lead to the release of biologically active ions at the defects, which could control the local pH in a suitable range for cell viability, and stimulate the new bone regeneration. As seen in the histological images, the implantation of m-MS/PBSu composite scaffolds did not cause any adverse reactions during the whole periods, indicating good biocompatibility.…”

Section: àmentioning

confidence: 99%

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Zheng

Zhang

et al. 2016

J. Mater. Chem. B

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Bioactive scaffolds of magnesium silicate (m-MS)/poly(butylene succinate) (PBSu) composites were fabricated by a solvent casting-particulate leaching method for bone regeneration. The scaffolds had a hierarchical porous structure with interconnected macropores (300-500 mm), micropores (1-10 mm) and mesopores (B5 nm). In addition, the composite scaffolds were degradable in Tris-HCl solution and The results demonstrated that the bioactive m-MS/PBSu composite scaffolds with good biocompatibility, degradability, bioactivity and osteogenesis are promising biomaterials for bone repair.

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Section: àmentioning

confidence: 99%

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Zheng

Zhang

et al. 2016

J. Mater. Chem. B

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“…One biomaterial-based regenerative approach involves the incorporation of biologically active moieties into biomaterials to enhance their bone regeneration properties (3). Strontium ranelate (SrRan) reduces vertebral and nonvertebral fractures in osteoporotic women (4,5).…”

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confidence: 99%

Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials

Autefage

Gentleman

Littmann

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Despite the increasing sophistication of biomaterials design and functional characterization studies, little is known regarding cells' global response to biomaterials. Here, we combined nontargeted holistic biological and physical science techniques to evaluate how simple strontium ion incorporation within the well-described biomaterial 45S5 bioactive glass (BG) influences the global response of human mesenchymal stem cells. Our objective analyses of whole gene-expression profiles, confirmed by standard molecular biology techniques, revealed that strontium-substituted BG up-regulated the isoprenoid pathway, suggesting an influence on both sterol metabolite synthesis and protein prenylation processes. This upregulation was accompanied by increases in cellular and membrane cholesterol and lipid raft contents as determined by Raman spectroscopy mapping and total internal reflection fluorescence microscopy analyses and by an increase in cellular content of phosphorylated myosin II light chain. Our unexpected findings of this strong metabolic pathway regulation as a response to biomaterial composition highlight the benefits of discovery-driven nonreductionist approaches to gain a deeper understanding of global cellmaterial interactions and suggest alternative research routes for evaluating biomaterials to improve their design.strontium-releasing biomaterials | human mesenchymal stem cells | microarray analysis | sparse feature selection analysis | mevalonate pathway A n important aim of regenerative medicine is to design smart biomaterials to trigger specific biological responses and enable complex tissue repair (1). Standard in vitro and in vivo testing of such materials usually focuses on assessing the anticipated cell response, often stem cell differentiation to a particular lineage and/or appropriate tissue formation. Although this strategy allows the characterization of specific outcomes, the global cell responses to most biomaterials remain relatively unknown and their mechanisms of action largely unidentified. In comparison with this standard approach, the pharmacology and molecular biology communities have revolutionized their respective fields by taking advantage of unsupervised "-omic" technologies that allow the global biological response to be examined without the inherent bias introduced by predicting particular outcomes. The adoption of comparable hypothesis-generating holistic approaches in the biomaterials communities could stimulate a similar paradigm shift, allowing prospective, rational material design instead of retrospective material evaluation.With more than 2.2 million bone-grafting procedures carried out annually worldwide, the market for smart biomaterials that can be used as functional alternatives to current autogenic and allogenic grafts is significant (2). One biomaterial-based regenerative approach involves the incorporation of biologically active moieties into biomaterials to enhance their bone regeneration properties (3). Strontium ranelate (SrRan) reduces vertebral and nonvertebral fr...

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“…With a contribution to a silane coupling agent, dispersibility of BGNs was improved and size of BGNs was changeable between 20 and 70 nm 20) . Recently, different ions have been added to BGNs, such as zirconium, zinc (Zn), magnesium (Mg), titanium, boron, copper (Cu), cobalt (Co) and silver (Ag) in order to improve functionality and bioactivity of BGNs 21) . However, it is not easy to prepare bioactive glasses in nano-size scale after addition of those ions.…”

Section: Sol-gel Techniquesmentioning

confidence: 99%

“…In another example, Ca 2+ and Si 4+ released from implanted bioactive glasses can be a precursor of HA and increase in pH, inducing antibacterial effects. Released Mg, Sr, Cu, Co, Ag and Ga ions as metal precursors from bioactive glasses could facilitate odontogenesis, osteogenesis, angiogenesis and antibacterial effects 21) . Applicable forms of bioactive glasses in dentistry can be diversified to particles, porous scaffolds, or dense constructs.…”

Section: Intrinsic Propertiesmentioning

confidence: 99%

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

2016

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Bioactive glass nanoparticles (BGNs) have been used over a range of dental tissue engineering. One main reason is possibly that BGNs strongly interact with hard tissues, while forming a stable interface after implantation. Recently, BGNs have been further diversified and ameliorated by incorporating bio-functional ions into BGNs or by functionally modifying the surface of BGNs. A comprehensive overview of the processes and applications of BGNs and their derivatives for the use in dentistry is thus necessary for their stepforward. Therefore, this review focuses on a variety of processes and practical applications of BGNs and their derivatives, which is expected to aid readerships with understanding and employing BGNs and their derivatives for personalized dental treatments.

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Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Cited by 435 publications

References 101 publications

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

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