1978
DOI: 10.1007/bf01683605
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Influence of Malathion (0,0′-dimethyl dithiophosphate of diethyl mercaptosuccinate) on body enzymes in dermal subacute toxicity studies inBubalus bubalis Species

Abstract: The effect of daily dermal spray of malathion for four weeks in recommended (0.5 and 1.0 per cent) and higher (5.0 per cent) concentration on various enzymes in Bubalus bubalis species were studied. The higher concentration of 5.0 per cent showed lethal effect after 2 to 3 exposures. The cholinesterase activity in both RBC (RChE) and plasma (PChE) were inhibited with all the concentrations. There was also significant (P less than 0.05) elevation in the activities of serum aspartate aminotransferase, alanine am… Show more

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Cited by 11 publications
(4 citation statements)
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“…It induces marked blood biochemical alterations that are qualitatively similar to the effects of other organophosphorus insecticides in buffalo species (V/adlamudi, 1974;Gupta and Paul, 1978;Malik et al, 1978a, b) …”
Section: Acute Toxicitymentioning
confidence: 89%
“…It induces marked blood biochemical alterations that are qualitatively similar to the effects of other organophosphorus insecticides in buffalo species (V/adlamudi, 1974;Gupta and Paul, 1978;Malik et al, 1978a, b) …”
Section: Acute Toxicitymentioning
confidence: 89%
“…Sastry and Sharma (1980) and Agrahari et al (2007) observed an increase in SGOT and SGPT in the blood of C. punctatus following treatment with mercuric chloride and monocrotophos, respectively. Vaglio and Landriscina (1999), Gupta and Paul (1978) and Palanivelu et al (2005) suggested that liver is rich in SGOT and SGPT, and damage to it could result in liberation of large quantities of these enzymes into the blood. An increase in these enzymes after exposure to pollutants is a sensitive indicator of cellular damage ( Van-Dar et al, 2003;Palanivelu et al, 2005).…”
Section: Resultsmentioning
confidence: 99%
“…Liver of vertebrates generally and fish particularly is the principal organ of detoxification (Freeman et al, 1983). So, the increase in AST might be attributed to tissue damage, particularly liver (Gupta &Paul, 1978 andPalanivelu et al, 2005). The elevation of these enzymes in the extracellular fluid or plasma is a sensitive indicator of cellular damage (Van der Oost et al, 2003 andPalanivelu et al, 2005).…”
Section: Discussionmentioning
confidence: 99%