Influence of Magnetic Nanoparticles on the Focused Ultrasound Hyperthermia

Abstract

Ultrasound hyperthermia is a medical treatment used to increase temperature of tissues. It can be used independently or as a supportive method for an anticancer treatment. The therapeutic efficacy of focused ultrasound hyperthermia can be improved using sonosensitizers, nanoparticles enhancing the attenuation and dissipation of acoustic energy. As sonosensitizers, we propose magnetic nanoparticles owing to their biodegradability, biocompatibility, and simple positioning in tissues using a magnetic field. Focused ultrasound hyperthermia studies were performed using tissue-mimicking phantoms. Temperature changes were measured at various ultrasound powers and distances from the center of the ultrasound focus. Specific absorption rate (SAR) values, describing the power deposition in the tissues during the hyperthermia treatment, were evaluated for the center of the focus point and for various distances from it. The results show that the addition of nanoparticles increases the SAR almost two times compared to that for the pure phantom. The highest SAR is obtained in the ultrasound focus; it decreases with the increase of the distance from the focus.

Colloids, nanoparticles, and materials for imaging, delivery, ablation, and theranostics by focused ultrasound (FUS)

“…They also observed that in the presence of SPIONs temperature increase in the tumor tissue was more than double compared to the sonication in the absence of SPIONs (15 °C vs. 38 °C). Józefczak and coworkers were obtained similar results in tissue-mimicking phantoms using SPIONs as well (Figure 12C) 200,201. The improved temperature increase in these studies is believed to be due to the enhanced attenuation and dissipation of acoustic energy in the presence of nanoparticles.…”

“…A and B are adapted from reference 14, copyright 2017 American Chemical Society. C is adapted from reference 201, copyright 2018 MDPI.…”

Enhancement of Neurite Outgrowth by Warming Biomaterial Ultrasound Treatment

“…Magnetic particles were embedded in warming biomaterials, so that they lacked the interaction of differences in compressibility, and the particles also had poor thermal transport effectivity, so the nanoparticles of the warming biomaterial heating mechanism were related in high density of magnetic nanoparticles to induce thermal effect [17]. In Józefczak's study [21], the attenuation of increased sonosensitizer enhanced ultrasonic-induced heating effectiveness, and the employed sonosensitizing material could obviously promote the heating rate compared to tissue-mimicking phantoms. Magnetic particles were embedded on warming biomaterials, so that there were no interaction differences in compressibility.…”

ESR Method in Monitoring of Nanoparticle Endocytosis in Cancer Cells

“…Nanomaterials are often a research object for their use in diagnostics and medical therapy [1][2][3][4][5][6]. Iron (II, III) oxide nanoparticles as potential materials for use in medical imaging [7,8], magnetic hyperthermia [9][10][11], and drug delivery carriers [12,13] are of great interest.…”