Influence of lung oxidant and antioxidant status on alveolarization: Role of light-exposed total parenteral nutrition

Lavoie, Jean-Claude; Rouleau, Thérèse; Tsopmo, Apollinaire; Friel, James K.; Chessex, Philippe

doi:10.1016/j.freeradbiomed.2008.04.018

Cited by 29 publications

(51 citation statements)

References 32 publications

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“…A significant effect induced by the type of nutrition could be explained either by a difference in the quality of nutrients or by the fact that both TPN solutions were contaminated with peroxides. This clinically tested mode of photoprotection (13,14,15) reduces by half the generation of peroxides in TPN solutions (23,25,26). Compared with controls, the similarity of effects on TG and blood glucose observed between the three groups suggests that even the lower amount of neonatal peroxides generated in photoprotected TPN was sufficient to induce modifications in metabolic programming later in life.…”

Section: Discussionmentioning

confidence: 91%

“…Therefore, the main active agents participating in the generation of peroxides in TPN are ambient light [(ϩ)L] and multivitamin preparations (MVP) (23,24). Photoprotection [(Ϫ)L] of TPN reduces the levels of peroxides by close to 50% (23,25,26). Absence of photoprotection of TPN is associated in preterm newborn infants with higher urinary peroxide concentrations (16), higher blood pressure in girl babies (15), and greater blood glucose and plasma triacylglycerol concentrations (13).…”

mentioning

confidence: 99%

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Neonatal Exposure to Oxidants Induces Later in Life a Metabolic Response Associated to a Phenotype of Energy Deficiency in an Animal Model of Total Parenteral Nutrition

et al. 2010

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Failure to protect total parenteral nutrition (TPN) from ambient light exacerbates the generation of peroxides, which affects blood glucose and plasma triacylglyceride (TG) in neonates. Based on the concept that the origin of adult diseases can be traced back to perinatal life, it was hypothesized that neonatal exposure to peroxides may affect energy availability later in life. Three-day-old guinea pigs, fitted with a jugular catheter, were fed regular chow (sham) Ϯ i. T he association between oxidative stress and characteristic features of the metabolic syndrome, such as diabetes, hypertension, and dyslipidemia, is well documented (1-6). Human (7) and animal studies (8,9) suggest that the origin of the metabolic syndrome can be traced back to perinatal life, a time when newborn infants are at greater risk of oxidative stress caused by weak antioxidant defenses (10 -12) or exposure to an oxidative environment or both (13-18). Several reports suggest that, in neonates, oxidative stress triggers the events that lead to programming of adult diseases (19 -22).Total parenteral nutrition (TPN) represents a source of oxidants in the form of peroxides that can be calibrated either by applying or not photoprotecting. The peroxides are derived from interactions between dissolved oxygen and electron donors such as lipid, amino acid, or ascorbic acid (23,24). The reaction is catalyzed by photoexcited riboflavin (24). Therefore, the main active agents participating in the generation of peroxides in TPN are ambient light [(ϩ)L] and multivitamin preparations (MVP) (23,24). Photoprotection [(Ϫ)L] of TPN reduces the levels of peroxides by close to 50% (23,25,26). Absence of photoprotection of TPN is associated in preterm newborn infants with higher urinary peroxide concentrations (16), higher blood pressure in girl babies (15), and greater blood glucose and plasma triacylglycerol concentrations (13). Hence, peroxides contaminating TPN solutions are not completely quenched by newborns infants and are thought to be an agent initiating metabolic perturbations. We questioned whether these peroxides are linked to metabolic consequences later in life.Based on the concept that neonatal oxidative stress may interfere with metabolic programming (27), we hypothesized that neonatal exposure to peroxides such as those generated in solutions of parenteral nutrition, induces a permanent modification in lipid and glucose metabolism especially lipogenesis and/or glycolysis. Perturbations in lipid and glucose metabolism, which are fuels for energy production, could have longterm consequences on growth and physical activity, thereby affecting global development. The aim of this study was to measure in adult guinea pigs metabolic responses and spontaneous physical activity after a brief neonatal exposure to i.v. oxidant molecules limited to the first wk of life. A second objective was to assess if these modifications were related to the infusion of peroxides. MATERIALS AND METHODSExperimental design. The metabolic response and the levels...

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Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

Neonatal Exposure to Oxidants Induces Later in Life a Metabolic Response Associated to a Phenotype of Energy Deficiency in an Animal Model of Total Parenteral Nutrition

et al. 2010

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“…Lung samples from premature baboons with BPD (Das et al, 2004) showed a large number of apoptotic events. In newborn guinea pigs given parenteral nutrition for 4 days, the alveolar count was 20% lower when the nutritive solution was infused without light protection, peroxide concentration being higher in light-exposed solutions (Section 5.2 below) (Lavoie et al, , 2005(Lavoie et al, , 2008. On histology, 30% of alveolar cells were in an apoptotic state .…”

Section: Redox Potential Of Glutathionementioning

confidence: 98%

“…Various factors may contribute to a shift in redox potential to a more oxidized state ( Figure 3, dashed line). An induced or sustained oxidized status favours the apoptosis process, leading to a loss of tissue such as observed in BPD (Das et al, 2004;Lavoie et al, , 2005Lavoie et al, , 2008. In preterm infants, these factors are oxygen supplementation, parenteral nutrition (containing peroxides), and inflammation.…”

Section: Redox Potential Of Glutathionementioning

confidence: 99%

“…In the presence of light, photoexcited riboflavin catalyzes a peroxide-producing reaction (Laborie et al, 1998). The simple act of adequately shielding parenteral nutrition solutions from ambient light halved the concentration of peroxides in the infused solution (Chessex et al, 2001;Laborie et al, 1998Laborie et al, , 1999Laborie et al, , 2000Lavoie et al, , 2007 as well as in the urine of preterm infants (Bassiouny et al, 2009;Chessex et al, 2001). Adequate photoprotection of parenteral nutrition has also been reported to reduce the incidence of chronic lung disease (Bassiouny et al, 2009) or BPD in premature infants.…”

Section: Parenteral Nutritionmentioning

confidence: 99%

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