Influence of lodgement site on the proliferation of metastases of Walker 256 carcinoma in the rat

Abstract

The growth of s.c. Walker 256 carcinoma was found to be independent of secondary growths induced by i.v. injection. Tumour cells injected i.v. lodged mainly in the lungs, with small clusters of cells in the lymph nodes. The rate of cellular proliferation of these secondary growths of Walker carcinoma was significantly higher than that observed in the s.c. tumour. In addition, host lung tissue was found to inhibit the development of metastases, and it is postulated that the host tissue may produce a diffusible inhibitor and that differences in the effectiveness of these humoral factors may account, in part, for locational differences in tumour growth patterns.

Walker Carcinoma 256: A Model for Studies on Tumor-Induced Anorexia and Cachexia

“…The tumor has been in tensively studied and is widely used for testing antitumoral agents [17][18][19]. However the existence of several Walker lines, some fast-and some slow-grow ing, makes comparison of the results obtained in various laboratories difficult [6,15,20,21].…”

Review: Biologic heterogeneity of cancer metastases

“…The effect of host tissues on tumor development is less well documented. Preferential growth in certain organs has been explained by local immune defenses [60-61], and diffusible inhibitors of tumor development may be released by certain tissues [62].…”

?Seed and soil? revisited: mechanisms of site-specific metastasis

“…Certain tissues may release factors that either inhibit or stimulate tumor cell proliferation (79,80). For example, extracts of rat kidney have been shown to inhibit DNA synthesis, as assessed by incorporation of tritiated thymidine, in cultured rat cells (80).…”