Influence of Liposomes on Tryptic Digestion of Insulin.

Kato, Yasuki; Hosokawa, Toshihito; Hayakawa, Eiji; Ito, Kunio

doi:10.1248/bpb.16.457

Cited by 31 publications

(12 citation statements)

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Section: Recent Advances In Modulating Liposomes For Oral Drug Delivementioning

confidence: 99%

“…In early developmental stages, it is an easy option to improve the physical stability of liposomes by optimizing lipid compositions. By incorporating stearylamine, liposomes are charged positively and are capable of suppressing the digestion of insulin by trypsin 68 and enhancing the hypoglycemic effect26., 69.. Replacing phospholipids or cholesterols with specific lipids or sterols improves the performance of oral liposomes due to enhanced stability in the GIT70., 71., 72., 73..…”

Section: Recent Advances In Modulating Liposomes For Oral Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Adapting liposomes for oral drug delivery

Lü

et al. 2019

Acta Pharmaceutica Sinica B

442

250

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Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.

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Section: Recent Advances In Modulating Liposomes For Oral Drug Delivementioning

confidence: 99%

Section: Recent Advances In Modulating Liposomes For Oral Drug Deliverymentioning

confidence: 99%

Adapting liposomes for oral drug delivery

Lü

et al. 2019

Acta Pharmaceutica Sinica B

442

250

View full text Add to dashboard Cite

show abstract

“…In fact, they have been found to enhance nasal absorption of peptides such as insulin and calcitonin by increasing their membrane penetration (156,157). This has been attributed to the increasing nasal retention of peptides (157), protection of the entrapped peptides from enzymatic degradation (158,159) and mucosal membrane disruption (160). Jain et al (156) incorporated insulin in liposomes coated with chitosan and carbapol and administered them intranasally to rats.…”

Section: Liposomesmentioning

confidence: 99%

Intranasal Drug Delivery: How, Why and What for?

2009

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Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs is increased. Since the nasal mucosa offers numerous benefits as a target tissue for drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topic, systemic and central nervous system action. We have, herein, outlined the relevant aspects of nasal anatomy, physiology and histology, and the biological, physicochemical and pharmaceutical factors that must be considered during the process of discovery and development of nasal drugs as well as in their incorporation into appropriate nasal pharmaceutical formulations. _______________________________________________________________________________________

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“…Liposomes have been extensively investigated for the nasal delivery of proteins; advantages include their protective effect on entrapped protein (Kato et al, 1993;Murramatsu et al, 1999), the ability to cause mucosal membrane disruption (Lee et al, 1991) and the capability of positively charged liposomes to increase residence time at the negatively charged mucosal surface (Law et al, 2001). Unfortunately they are easily removed by MCC.…”

Section: Introductionmentioning

confidence: 99%