2016
DOI: 10.1371/journal.pone.0161041
|View full text |Cite|
|
Sign up to set email alerts
|

Influence of Light Emitting Diode-Derived Blue Light Overexposure on Mouse Ocular Surface

Abstract: PurposeTo investigate the influence of overexposure to light emitting diode (LED)-derived light with various wavelengths on mouse ocular surface.MethodsLEDs with various wavelengths were used to irradiate C57BL/6 mice at an energy dose of 50 J/cm2, twice a day, for 10 consecutive days. The red, green, and blue groups represented wavelengths of 630 nm, 525 nm, and 410 nm, respectively. The untouched group (UT) was not exposed to LED light and served as the untreated control. Tear volume, tear film break-up time… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

5
49
0
1

Year Published

2016
2016
2023
2023

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 40 publications
(55 citation statements)
references
References 55 publications
(53 reference statements)
5
49
0
1
Order By: Relevance
“…One should note that the majority of harmful effects observed in this work were not detected after exposure to the control red light, thus confirming the blue wavelength specificity of the presented phototoxic effects. Moreover, it is worth to note that our findings are in line with recent in vivo results of Lee et al who reported that overexposure to blue light induced oxidative damage and apoptosis to the cornea, probably resulting in increased ocular surface inflammation and dry eye [2]. Our work demonstrates the deleterious effects of blue light on the eye, not only on the retina but on the ocular surface.…”
Section: Discussionsupporting
confidence: 92%
See 2 more Smart Citations
“…One should note that the majority of harmful effects observed in this work were not detected after exposure to the control red light, thus confirming the blue wavelength specificity of the presented phototoxic effects. Moreover, it is worth to note that our findings are in line with recent in vivo results of Lee et al who reported that overexposure to blue light induced oxidative damage and apoptosis to the cornea, probably resulting in increased ocular surface inflammation and dry eye [2]. Our work demonstrates the deleterious effects of blue light on the eye, not only on the retina but on the ocular surface.…”
Section: Discussionsupporting
confidence: 92%
“…Today it is widely discussed that blue light may provoke an important ocular phototoxicity [1]. Various blue and UV light-induced and/or -aggravated ocular pathologies have been recognized, including photokeratitis, pterygium, cataract, and corneal and retinal degeneration [2][3][4][5][6]. In particular, patients suffering from dry eye disease (DED) frequently complain about the exacerbated photosensitivity and increased symptoms of discomfort when exposed to various visible light sources [7,8].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…[ 9 ] Overexposure to blue light caused deterioration of the tear film and increased levels of inflammatory markers and reactive oxygen species (ROS) production at the ocular surface of mice. [ 10 ]…”
Section: Introductionmentioning
confidence: 99%
“…Lee HS, Cui L, Li Y, Choi JS, Choi J-H, Li Z, et al (2016) Correction: Influence of Light Emitting Diode-Derived Blue Light Overexposure on Mouse Ocular Surface. PLoS ONE 11(11): e0167671.…”
mentioning
confidence: 99%