Influence of L-carnitine administration on maximal physical exercise

Vecchiet, L; Lisa, Fabio Di; Pieralisi, G; Ripari, Patrizio; Menabò, Roberta; Giamberardino, M. A.; Siliprandi, N.

doi:10.1007/bf00236072

Cited by 90 publications

(50 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a CAF trial alone did not affect exercise endurance time. Vecchiet et al (47) have reported that pretreatment L-CAR (2g) in creased work capacity with increasing VO2max, but without affecting RQ. They discussed two possible mechanisms for their results: 1) The administration of CAR during exercise might reduce acyl-CoA accumula tion, which has adverse effects on energy production;…”

Section: Discussionmentioning

confidence: 99%

Effects of Carnitine Coingested Caffeine on Carnitine Metabolism and Endurance Capacity in Athletes.

Cha

Choi

Suh³

et al. 2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

SummaryThe purpose of this study was to examine whether caffeine (CAF), carnitine (CAR), or CAP+CAR mixture administration affects exercise endurance time via carnitine metabolism. Water (CON), CAF, CAR, or CAF+CAR mixture was administered to five male rugby athletes participating in this study by a randomized double-blind fashion who were made to ride a cycle ergometer for exercise. The CAF effect on exercise endurance time was small, but the CAR trial significantly increased the exercise endurance time compared with CON trial; a further CAP +CAR mixture trial had greater effects on the exercise endurance time than those of a CON, CAF, or CAR trial. A CAR or CAF+CAR mixed trial increased uri nary nonesterified carnitine (NEC) and total carnitine (TCAR), but no changes were ob served in acid-soluble acylcarnitine (ASAC) and acid-insoluble acylcarnitine (AIAC) excre tion. A CAR or CAF+CAR mixed trial resulted in higher levels of plasma NEC, ASAC, and TCAR fractions than the CON and CAF trials did on exhaustion time. Total cholesterol, triglyceride, and free fatty acid in blood were significantly increased at exhaustion time, but they were not affected in the CAF or the CAR trial. These results suggest that carnitine in gestion could promote fat oxidation, resulting in higher endurance performance in athletes, and especially these ergogenic effects of carnitine coingested with caffeine may be greater than those of carnitine alone.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Carnitine Coingested Caffeine on Carnitine Metabolism and Endurance Capacity in Athletes.

Cha

Choi

Suh³

et al. 2001

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

View full text Add to dashboard Cite

show abstract

“…However, no information is currently available on respiratory muscle training associated with L-carnitine. Previous studies have observed the effects of L-carnitine supplementation on muscle performance, delayed muscle fatigue in vitro (9), increased workload during an incremental test in healthy subjects (39) and athletes (40), reduced muscle fatigue in hemodialysis patients (35), or improved myocardial performance in congestive heart failure patients (29).…”

Section: Discussionmentioning

confidence: 99%

L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs

Borghi‐Silva

Baldissera

Sampaio

et al. 2006

Braz J Med Biol Res

View full text Add to dashboard Cite

The effects of adding L-carnitine to a whole-body and respiratory training program were determined in moderate-to-severe chronic obstructive pulmonary disease (COPD) patients. Sixteen COPD patients (66 ± 7 years) were randomly assigned to L-carnitine (CG) or placebo group (PG) that received either L-carnitine or saline solution (2 g/day, orally) for 6 weeks (forced expiratory volume on first second was 38 ± 16 and 36 ± 12%, respectively). Both groups participated in three weekly 30-min treadmill and threshold inspiratory muscle training sessions, with 3 sets of 10 loaded inspirations (40%) at maximal inspiratory pressure. Nutritional status, exercise tolerance on a treadmill and six-minute walking test, blood lactate, heart rate, blood pressure, and respiratory muscle strength were determined as baseline and on day 42. Maximal capacity in the incremental exercise test was significantly improved in both groups (P < 0.05). Blood lactate, blood pressure, oxygen saturation, and heart rate at identical exercise levels were lower in CG after training (P < 0.05). Inspiratory muscle strength and walking test tolerance were significantly improved in both groups, but the gains of CG were significantly higher than those of PG (40 ± 14 vs 14 ± 5 cmH 2 O, and 87 ± 30 vs 34 ± 29 m, respectively; P < 0.05). Blood lactate concentration was significantly lower in CG than in PG (1.6 ± 0.7 vs 2.3 ± 0.7 mM, P < 0.05). The present data suggest that carnitine can improve exercise tolerance and inspiratory muscle strength in COPD patients, as well as reduce lactate production.

show abstract

“…Paralelamente a esses resultados, algumas pesquisas conseguiram demonstrar uma correlação entre a suplementação de Lcarnitina e melhorias no consumo máximo de oxigênio (MARCONI, et al 1985;VECCHIET, et al 1990;GALLOWAY, et al 2004). Ao mesmo tempo, em situações de hipóxia ou ausência de oxigênio, a fosforilação oxidativa fica impedida na mitocôndria, e a célula fica dependente de vias anaeróbicas para a obtenção de energia (PINHEIRO, 1999).…”

Section: (Figura 2)unclassified

“…Desta maneira, alguns estudos encontraram relação entre a suplementação de L-carnitina e redução de lactato VECCHIET, et al 1990). Porém, a maioria dos estudos não foi capaz de demonstrar efeitos positivos da suplementação com Lcarnitina sobre a redução do acúmulo de lactato e o desempenho em indivíd uos saudáveis (GREIG, et al 1987;MARCONI, et al 1985;OYONO-ENGUELLE, et al 1988;RANSONE & LEFAVI, 1997).…”

Section: (Figura 2)unclassified

Efeitos ergogênicos da L-carnitina no metabolismo lipídico

Maffini

Peloso

2017

RESC

View full text Add to dashboard Cite

RESUMO:Diante da epidemia global de obesidade, suplementos termogênicos tem ganhado destaque com a promessa de diminuição da gordura e melhora na composição corporal. Para tanto, o uso de L-carnitina propõe uma maior oxidação de ácidos graxos, com a diminuição no uso de substâncias glicídicas no metabolismo energético, levando a uma redução nos níveis de gordura corporal. Nesse sentido, esse artigo tem como objetivo revisar a bibliografia acerca do emprego da L-carnitina, ressaltando a relevância e os benefícios associados com a sua suplementação. Dessa forma, as pesquisas sugerem ser possível aumentar a concentração endógena de carnitina, em algumas populações, através da suplementação, que também pode ser estimulada pela concentração de insulina. Por consequência, há priorização no uso de ácidos graxos como fonte energética, em detrimento de glicogênio muscular, ocasionando uma diminuição nos estoques de gordura corporal e beneficiando determinadas modalidades esportivas. No entanto, em razão da escassez de pesquisas sobre o tema, do reduzido tempo empregado na análise dos estudos realizados, bem como, a presença de resultados conflitantes, fazem-se necessárias mais pesquisas sobre o efeito ergogênico da substância. PALAVRAS-CHAVE:L-carnitina. Suplemento. Atividade física.

show abstract

Influence of L-carnitine administration on maximal physical exercise

Cited by 90 publications

References 17 publications

Effects of Carnitine Coingested Caffeine on Carnitine Metabolism and Endurance Capacity in Athletes.

Effects of Carnitine Coingested Caffeine on Carnitine Metabolism and Endurance Capacity in Athletes.

L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs

Efeitos ergogênicos da L-carnitina no metabolismo lipídico

Contact Info

Product

Resources

About