Influence of isosorbide dinitrate on superior mesenteric artery impedance in humans

Abstract

In a randomized, double-blind, placebo-controlled crossover study the acute effect of isosorbide dinitrate (ISDN) on the superior mesenteric artery velocity waveform was studied in 10 healthy subjects (mean age 48.2 years) over a 10-minute period. The superior mesenteric artery pulsatility index (PI), which quantifies the blood velocity waveform, increased from the second minute following sublingual administration of 5 mg ISDN (basal PI 4.88 +/- 0.32) and reached its upper level (8.22 +/- 1.38) from the fourth minute on. In comparison with placebo, the significant rise of PI (second minute) occurred before the significant decrease of systolic blood pressure (ninth minute) and before the significant increase in the heart rate (fourth minute). Diastolic and mean arterial blood pressures remained unchanged. These observations suggest an immediate vasoconstrictive effect of ISDN on the resistance vessels of the vascular bed of the superior mesenteric artery.

Splenic Doppler impedance indices: Influence of different portal hemodynamic conditions

“…Cirrhotic patients who underwent surgery been introduced: at first portal blood flow velocity and for the therapy of portal hypertension showed splenic the congestion index of the portal vein, 1,[3][4][5][6] and more recently, the arterial hemodynamic parameters, i.e., the so-called impedance or resistance indices. [7][8][9] The…”