Influence of Intraperitoneal Application of Taurolidine/Heparin on Expression of Adhesion Molecules and Colon Cancer in Rats Undergoing Laparoscopy

Bobrich, E.; Braumann, Chris; Opitz, Isabelle; Menenakos, Charalambos; Kristiansen, Glen; Jacobi, C. A.

doi:10.1016/j.jss.2006.07.013

Cited by 11 publications

(9 citation statements)

References 40 publications

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“…However, previous experimental studies with tumor load showed no influence of TRD in hemopoiesis, renal and liver function which are commonly affected by usual chemotherapeutics [5,8,30] .…”

Section: Discussionmentioning

confidence: 85%

Wound Healing Is Not Impaired in Rats Undergoing Perioperative Treatment with the Antineoplastic Agent Taurolidine

Braumann

Guenther²,

Pohlenz³

et al. 2008

Eur Surg Res

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Background/Aim: The aim of this study was to determine whether an intravenous or an intraperitoneal application of the antineoplastic agent taurolidine (TRD) impairs wound healing in the absence of tumor load in rats. Methods: Eighty rats were randomized into eight groups (n = 10). Median laparotomy was performed in all animals. Three groups were treated by intravenous injection and three groups by local administration using a central port catheter system. For each group, 1 ml was applied: isotone sodium chloride solution (control groups), 1% TRD, 2% TRD, and 3% TRD. Fascia and skin were closed using a standardized running suture technique with 4-0 Vicryl®. Wounds were evaluated once a day. Animals were treated every 8 h for 7 days (ports were then removed) and wounds were evaluated at day 28. Macroscopic and histopathologic examinations of scar tissue biopsies (hemalaun-eosin stain) were performed at the end of the experiment. Results: No animal died. No relevant impairment of wound healing was observed independent of the different treatment strategies. Conclusion: Our results suggest that wound healing does not seem to be impaired by TRD in rats.

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Section: Discussionmentioning

confidence: 85%

Wound Healing Is Not Impaired in Rats Undergoing Perioperative Treatment with the Antineoplastic Agent Taurolidine

Braumann

Guenther²,

Pohlenz³

et al. 2008

Eur Surg Res

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“…While most investigators used barbiturate [19,20,22] or ketamine [16-18,21,23] for narcosis, we used isoflurane (Forene®, Abbott GmbH & Co KG, Wiesbaden, Germany), which was also used by Schmelzer et al . [24].…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the capnoperitoneum, several investigators used an angiocatheter (18 or 25 gauge) in a trocarless method to insufflate the peritoneal cavity [16,17,21,23], while others used proper trocars [18-20,22,24]. As the usage of trocars appears to imitate LA more realistically in comparison with modern human laparoscopy, we consequently used trocars within the present study.…”

Section: Resultsmentioning

confidence: 99%

“…In CA models, for example, electrosurgical devices (bipolar cautery [11,14], LigaSure Precise [12,14]), endoclips [12-14], endoloops [13,23] and staplers [13,15] have been compared, and all investigated methods have been shown to be feasible, safe and leakproof. While some of the LA rat models also investigated caecum resection and closure techniques, other groups focused on topics such as postoperative immune function [16,17,21,24], risk of neoplastic port site metastasis after LS [18,23], influence of taurolidine/heparin on local tumour growth after laparoscopy [20,22] and postoperative adhesion formation [19]. With our standardized model, we hope to facilitate such research in the future to improve LS.…”

Section: Resultsmentioning

confidence: 99%

“…However, the data available on laparoscopic caecum resection in rats is scarce; small cohorts of animals have been used and incomplete procedural descriptions have been presented by some authors [16-24]. Furthermore, a majority of published operations must essentially be classified as hybrid interventions rather than pure LS [16-22,24]. Polat et al .…”

Section: Introductionmentioning

confidence: 99%

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Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats

et al. 2014

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BackgroundLaparoscopic appendectomy (LA) has become one of the most common surgical procedures to date. To improve and standardize this technique further, cost-effective and reliable animal models are needed.MethodsIn a pilot study, 30 Wistar rats underwent laparoscopic caecum resection (as rats do not have an appendix vermiformis), to optimize the instrumental and surgical parameters. A subsequent test study was performed in another 30 rats to compare three different techniques for caecum resection and bowel closure.ResultsBipolar coagulation led to an insufficiency of caecal stump closure in all operated rats (Group 1, n = 10). Endoloop ligation followed by bipolar coagulation and resection (Group 2, n = 10) or resection with a LigaSure™ device (Group 3, n = 10) resulted in sufficient caecal stump closure.ConclusionsWe developed a LA model enabling us to compare three different caecum resection techniques in rats. In conclusion, only endoloop closure followed by bipolar coagulation proved to be a secure and cost-effective surgical approach.

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Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines

Hotz

Erben

Arndt

et al. 2014

Int J Colorectal Dis

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Influence of Intraperitoneal Application of Taurolidine/Heparin on Expression of Adhesion Molecules and Colon Cancer in Rats Undergoing Laparoscopy

Cited by 11 publications

References 40 publications

Wound Healing Is Not Impaired in Rats Undergoing Perioperative Treatment with the Antineoplastic Agent Taurolidine

Wound Healing Is Not Impaired in Rats Undergoing Perioperative Treatment with the Antineoplastic Agent Taurolidine

Development of a standardized laparoscopic caecum resection model to simulate laparoscopic appendectomy in rats

Taurolidine induces epithelial-mesenchymal transition via up-regulation of the transcription factor Snail in human pancreatic cancer cell lines

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