Influence of Insulin Resistance Status on the Development of Gallstones Following Roux-En-Y Gastric Bypass: a Prospective Cohort Study

Cazzo, Everton; Gestic, Martinho Antônio; Machado, Ricardo Rossetto; Jimenez, Laísa Simakawa; Silva, Amanda Pinter Carvalheiro da; Baracat, Jamal; Callejas-Neto, Francisco; Pareja, José Carlos; Chaim, Élinton Adami

doi:10.1007/s11695-015-1815-3

Cited by 17 publications

(11 citation statements)

References 49 publications

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“…A study found that patients with metabolic syndrome had more deficiencies other than did patients without metabolic syndrome (25). However, hyperinsulinemia appears to be an independent risk factor for cholelithiasis development after bariatric surgery (15,26).…”

Section: Discussionmentioning

confidence: 99%

The Incidence and Risk Factors of Cholelithiasis Development After Bariatric Surgery in Saudi Arabia: A Two-Center Retrospective Cohort Study

et al. 2020

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Section: Discussionmentioning

confidence: 99%

The Incidence and Risk Factors of Cholelithiasis Development After Bariatric Surgery in Saudi Arabia: A Two-Center Retrospective Cohort Study

et al. 2020

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“…Although these hormones have been identified in the early 1970s, they really rose to prominence after the growth of bariatric surgery and the observation of the critical impact of these procedures on their release and, consequently, on the glucose homeostasis and improvement of metabolic syndrome and its clinical features (16)(17)(18)(19)(20)(21)(22)(28)(29)(30)(31)(32)(33)(34) . In this study, we observed that the GLP-1 levels did not differ among non-diabetic individuals with morbid obesity, diabetic individuals with mild obesity and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Levels of C-Reactive Protein, GLP-1 and GLP-2 Among Individuals With Diabetes, Morbid Obesity and Healthy Controls: An Exploratory Study

Cazzo

Pareja

Chaim

et al. 2018

Arq. Gastroenterol.

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-Background -The glucagon-like peptides 1 and 2 (GLP-1/GLP-2) are gut hormones that may directly affect the glucose homeostasis and their activity seems to be significantly affected by chronic inflammation. Objective -To evaluate the postprandial levels of glucagon-like peptides 1 and 2 (GLP-1/GLP-2), C-reactive protein (CRP), and the postprandial glucose and insulin levels among individuals with obesity, type 2 diabetes, and healthy controls. Methods -An exploratory cross-sectional study, which involved individuals awaiting for bariatric/metabolic surgery and healthy controls. Postprandial levels of GLP-1, GLP-2, glucose, and insulin were obtained after a standard meal tolerance test. Inflammation was assessed by means of CRP. Results -There were 30 individuals enrolled in the study, divided into three groups: non-diabetic with morbid obesity (NDO; n=11 individuals), diabetic with mild obesity (T2D; n=12 individuals), and healthy controls (C; n=7 individuals). The mean CRP levels were significantly higher in the NDO group (6.6±4.7 mg/dL) than in the T2D (3.3±2.2 mg/dL) and C groups (2.5±3.2 mg/dL) (P=0.038). The GLP-1 levels following standard meal tolerance test and the area under the curve of GLP-1 did not differ among the three groups. The GLP-2 levels were significantly lower in the NDO and T2D than in the C group following standard meal tolerance test at all the times evaluated. The area under the curve of the GLP-2 was significantly lower in the NDO and T2D groups than in the C group (P=0.05 and P=0.01, respectively). Conclusion -GLP-2 levels were impaired in the individuals with obesity and diabetes. This mechanism seems to be enrolled in preventing the worsening of the glucose homeostasis in these individuals. HEADINGS -Glucagon-like peptide 1. Glucagon-like peptide 2. Diabetes mellitus. Obesity. Insulin resistance. Incretins.

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“…We are not aware of any randomized controlled trials assessing symptomatic gallstone disease after bariatric surgery as a predefined endpoint, and observational studies that have addressed this question are short, retrospective, and lack a proper control group [9][10][11][12][13][14][15][16]26]. Studies with a follow-up of 6-24 months report an incidence of cholecystectomy in postbariatric surgery populations that range from 3.3% [19] to 14.7 % [27], and a meta-analysis found a rate of 6.8 % based on 13 studies of which all but 1 were retrospective [12].…”

Section: Discussionmentioning

confidence: 99%

“…It is also an established treatment for type 2 diabetes in patients with obesity [5]. However, obesity as well as rapid weight loss are risk factors for gallstone disease [6], and gallstone disease is a well-known complication of bariatric surgery [7][8][9][10][11][12][13][14][15][16]. Gallstone disease in patients who underwent gastric bypass surgery may also impose treatment challenges in the presence of common duct gallstones.…”

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confidence: 99%

Long-term incidence of gallstone disease after bariatric surgery

Anveden

Peltonen

Näslund

et al. 2020

Surgery for Obesity and Related Diseases

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Background: Gallstone disease is a known short-term complication of bariatric surgery; little is known of the long-term incidence. Objectives: The aim of this study was to investigate the association between bariatric surgery and long-term incidence of gallstone disease. Settings: A total of 25 surgery departments and 480 primary healthcare centers in Sweden. Methods: The Swedish Obese Subjects study is a prospective, controlled study comparing the effects of bariatric surgery with usual care with a follow-up of 20 years, including 4047 individuals. The current report includes all participants without previous or concomitant cholecystectomy (n 5 3597). Operative techniques used in the surgery group (n 5 1755) were gastric bypass (n 5 236), vertical banded gastroplasty (n 5 1202), and gastric banding (n 5 317). The control group (n 5 1842) received customary treatment for obesity. Gallstone disease was a predefined secondary endpoint in the Swedish Obese Subjects study and the primary endpoint of this report. Data were obtained by cross-checking our study database with the Swedish National Patient Register of diagnosis and procedures. Results: In the surgery and control groups, respectively, there were 307 and 252 first-time events of symptomatic gallstone disease and 230 and 170 cholecystectomies (log-rank P , .001, both outcomes). Bariatric surgery was associated with an increased risk of symptomatic gallstone disease, with a more pronounced risk during the first years of follow-up (P 5 .002) and an increased risk for cholecystectomy but with no time-varying effect (P 5 .213). Conclusions: Bariatric surgery increases the risk for symptomatic gallstone disease and cholecystectomy, especially during the first years following treatment.

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Influence of Insulin Resistance Status on the Development of Gallstones Following Roux-En-Y Gastric Bypass: a Prospective Cohort Study

Cited by 17 publications

References 49 publications

The Incidence and Risk Factors of Cholelithiasis Development After Bariatric Surgery in Saudi Arabia: A Two-Center Retrospective Cohort Study

The Incidence and Risk Factors of Cholelithiasis Development After Bariatric Surgery in Saudi Arabia: A Two-Center Retrospective Cohort Study

Comparison of the Levels of C-Reactive Protein, GLP-1 and GLP-2 Among Individuals With Diabetes, Morbid Obesity and Healthy Controls: An Exploratory Study

Long-term incidence of gallstone disease after bariatric surgery

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