Influence of infusion line compliance on drug delivery rate during acute line loop formation

Weiß, Markus; Bänziger, O.; Neff, Thomas; Fanconi, Sergio

doi:10.1007/s001340051246

Cited by 55 publications

(40 citation statements)

References 9 publications

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“…7 Infusion line compliance may further influence pump performance substantially. 9 The importance of using the original stiff, low compliant tube extension set with a very small inner diameter was demonstrated by the four-fold increase in ZDDT when it was replaced by the soft, more compliant Injectomat® infusion line (Table II). 9 The design of the tested PMV infusion device results in minimal mechanical gaps, a low overall system compliance and contributes to its optimized functional performance.…”

Section: Discussionmentioning

confidence: 99%

“…9 The importance of using the original stiff, low compliant tube extension set with a very small inner diameter was demonstrated by the four-fold increase in ZDDT when it was replaced by the soft, more compliant Injectomat® infusion line (Table II). 9 The design of the tested PMV infusion device results in minimal mechanical gaps, a low overall system compliance and contributes to its optimized functional performance. 10 Even though this device may be very advantageous in terms of high flow accuracy and low susceptibility to vertical displacement several points with respect to its potential use in pediatric anesthesia and intensive care medicine must be mentioned: First, in case of accidental occlusion, the device's cut-out pressure is set at 4 bar, resulting in a maximum back-up bolus of 80 µL (manufacturer's specifications).…”

Section: Discussionmentioning

confidence: 99%

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The Panomat® P-10 micro-volumetric infusion pump is suitable for continuous drug administration at minimal flow rates

Neff

Fellmann

Fuechslin³

et al. 2002

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To evaluate the performance of the Panomat® P-10 micro-volumetric infusion pump for its use in drug administration at minimal flow rates (µL·hr -1 ; e.g., intrathecal application).M Me et th ho od ds s: : Fluid delivery at steady state conditions, and after vertical displacement of the syringe pump by -50 cm was determined gravimetrically. The Panomat® P-10 infusion pump was evaluated at 4, 10, 20, 50 and 100 µL·hr -1 , and compared to a conventional syringe pump assembly at 100, 200, 500 and 1000 µL·hr -1 . Measurements were repeated twice with two different devices of each syringe pump system, and with two syringes. Data are reported as mean ± SD. R Re es su ul lt ts s: : Steady state fluid delivery of the Panomat® P-10 infusion pump revealed less than 5% deviation to set flow rate at 10, 20, 50 and 100 µL·hr -1 , and 12% deviation at 4 µL·hr -1 . Mean zero-drug delivery time (ZDDT) after lowering the pump by 50 cm at 4 µL·hr -1 flow rate was 38.4 ± 7.3 min. At 100 µL·hr -1 and with original infusion line ZDDT was almost 20 times shorter when compared to the conventional syringe pump assembly (1.5 ± 0.5 min vs 28.5 ± 5.0 min). C Co on nc cl lu us si io on n: : The tested Panomat® P-10 micro-volumetric pump shows an acceptable flow accuracy as well as a low susceptibility to vertical displacement, and is therefore suitable for continuous drug administration at minimal flow rates. The technology used in this pump carries potential implications for a new generation of syringe pumps. (1,5 ± 0,5 min vs 28,5 ± 5,0 min Objectif

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Panomat® P-10 micro-volumetric infusion pump is suitable for continuous drug administration at minimal flow rates

Neff

Fellmann

Fuechslin³

et al. 2002

Can J Anesth/J Can Anesth

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“…The compliance of the drug delivery tubing affects the variability of its infusion rate, affecting the time to initiate the occlusion alarm, time without flow, suction volume, and bolus volume during vertical movements of the syringe pump [16,17]. The impact of this factor is further enhanced in combination with high volume syringes (50 mL) and low flow programming.…”

Section: Factorsmentioning

confidence: 99%

Avoid Drug Incompatibilities: Clinical Context in Neonatal Intensive Care Unit (NICU)

Flamein

Storme

Maiguy-Foinard

et al. 2017

Pharmaceutical Technology in Hospital Pharmacy

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AbstractThe administration of several intravenous products on the same catheter is a very common situation in neonatology, where the stakes are high and the dangers sometimes unknown to clinicians. A large number of factors are involved in this administration, directly related to the installation of the infusion line. Moreover, the therapeutics used are often limited, and excluding classic “Marketing Authorization”. Some of these products may prove to be incompatible and thus lose their effectiveness, or even generate particles that are likely to be administered to the patient. We must be aware of these risks in order to optimize the prescription and administration of these intravenous products, especially as we treat fragile and immature patients. The aim of this work is to review the literature on the subject for the prescribers of neonatology units.

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“…Diese Schwankungen sind auf Veränderungen des hydrostatischen Drucks innerhalb des Infusionssystems zurückzuführen [6]. Das Ausmaß der Unregelmässigkeiten ist von der Compliance der Infusionsschläuche, der Infusionsspritzen und der Spritzenpumpen abhängig, die bei wechselnden hydrostatischen Durckverhältnissen beim Absenken der Spritzenpumpe zum Pooling von Infusat ins Infusionssystem und vice versa beim Anheben der Spritzenpumpe auf das Ausgangsniveau zum Entleeren eines Infusionsbolus in die venöse Strombahn führt [8,13].…”

Section: Zusammenfassungunclassified

Auswirkungen von Luftbläschen in der Infusionsspritze auf die Funktion von Spritzenpumpen

et al. 2000

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Application of highly concentrated short-acting vasoactive drugs in the critically ill patient requires precisely working syringe pump systems for continuous intravenous drug delivery. We performed a bench study to investigate the consequences of small amounts of air entrapped within a 50-ml infusion syringe. In particular we studied the effect of entrapped air on drug delivery after moderate vertical displacement of the pump by 50 cm (e.g. in preparation for transport) and the effect on the time required to trigger the pressure alarm after occlusion of the infusion line. At a flow rate of 1 ml/h, lowering the syringe pump prolonged the zero-drug delivery time from (mean +/- SD) 4.1 +/- 0.8 min (without air) to 6.2 +/- 0.9 (with 1 ml air) and to 13.1 +/- 0.9 min (with 2 ml of air, p < 0.001 for all comparisons). Entrapping of 2 ml of air within the syringe resulted in a 2.6-fold prolongation of the occlusion alarm time after accidental occlusion of the infusion line and a 3-fold increase of the resulting infusion bolus after occlusion. Enclosed air within infusion syringes considerably affects the syringe compliance. It increases the susceptibility of constant drug delivery to vertical displacement of syringe pumps and impairs the occlusion alarm function. Therefore, any air in syringe of infusion pump systems should be carefully removed. To avoid infusion boluses of short-acting vasoactive drugs after accidental occlusions, the occluded infusion line should be released to ambient pressure first.

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Influence of infusion line compliance on drug delivery rate during acute line loop formation

Cited by 55 publications

References 9 publications

The Panomat® P-10 micro-volumetric infusion pump is suitable for continuous drug administration at minimal flow rates

The Panomat® P-10 micro-volumetric infusion pump is suitable for continuous drug administration at minimal flow rates

Avoid Drug Incompatibilities: Clinical Context in Neonatal Intensive Care Unit (NICU)

Auswirkungen von Luftbläschen in der Infusionsspritze auf die Funktion von Spritzenpumpen

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