P Pu ur rp po os se e: : To evaluate the performance of the Panomat® P-10 micro-volumetric infusion pump for its use in drug administration at minimal flow rates (µL·hr -1 ; e.g., intrathecal application).M Me et th ho od ds s: : Fluid delivery at steady state conditions, and after vertical displacement of the syringe pump by -50 cm was determined gravimetrically. The Panomat® P-10 infusion pump was evaluated at 4, 10, 20, 50 and 100 µL·hr -1 , and compared to a conventional syringe pump assembly at 100, 200, 500 and 1000 µL·hr -1 . Measurements were repeated twice with two different devices of each syringe pump system, and with two syringes. Data are reported as mean ± SD. R Re es su ul lt ts s: : Steady state fluid delivery of the Panomat® P-10 infusion pump revealed less than 5% deviation to set flow rate at 10, 20, 50 and 100 µL·hr -1 , and 12% deviation at 4 µL·hr -1 . Mean zero-drug delivery time (ZDDT) after lowering the pump by 50 cm at 4 µL·hr -1 flow rate was 38.4 ± 7.3 min. At 100 µL·hr -1 and with original infusion line ZDDT was almost 20 times shorter when compared to the conventional syringe pump assembly (1.5 ± 0.5 min vs 28.5 ± 5.0 min). C Co on nc cl lu us si io on n: : The tested Panomat® P-10 micro-volumetric pump shows an acceptable flow accuracy as well as a low susceptibility to vertical displacement, and is therefore suitable for continuous drug administration at minimal flow rates. The technology used in this pump carries potential implications for a new generation of syringe pumps. (1,5 ± 0,5 min vs 28,5 ± 5,0 min
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