Influence of influenza vaccine and comorbidity on the evolution of hospitalized COVID-19 patients⋆

Ibáñez, José Manuel Fernández; Ballesteros, María del Carmen Morales; Anguita, Manuel José Fernández; Andúgar, María Ángeles Galindo; Arias, Ángel; Barberá-Farré, José Ramón

doi:10.1016/j.medcle.2021.06.022

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…Since influenza almost disappeared during the 2020 season 17–23 and thus the prevention of co‐infection could not explain this possible protective effect of the influenza vaccination on COVID‐19, it was hypothesized that influenza vaccination directly played protective roles against SARS‐CoV‐2 infection. The ensuing studies on the association between influenza vaccination and SARS‐CoV‐2 infection and COVID‐19 severity were the basis for this meta‐analysis 38–88 …”

Section: Discussionmentioning

confidence: 99%

“…The reason for exclusion of other trials was specified (lack of details, no controls, Figure 1). In total: 51 studies, 33 studies for infection (with 37 comparison arms), 38–70 14 studies (with 14 comparison arms) for hospitalization, 43,46,53,54,57,69,71–78 11 studies (with 11 comparison arms) for admission to ICU, 42,53,54,73,77–79 and 19 studies (with 20 comparison arms) for mortality 43,53,57,61,69,75–78,80–88 fulfilled the inclusion criteria. Tables 1A,B,C,D show details of studies included in this meta‐analysis.…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, the quality of studies, as assessed through the NOS was elevated, with a few exceptions, and no publication bias was evident. Finally, even though all subjects in the studies did not receive any anti‐SARS‐CoV‐2 vaccine, we had no information about previous infections with SARS‐CoV‐2, and, with few exceptions, 44,45,51,57,59,65,82,83 about recent infections with the influenza virus, and we had no data on the possible involvement of the cardiovascular system in the studies evaluated 1–4 …”

Section: Limitationsmentioning

confidence: 99%

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Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis

Pontiroli,

Scovenna,

Carlini

et al. 2024

Journal of Medical Virology

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Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) causes COVID‐19 and has brought a huge burden in terms of human lives. Strict social distance and influenza vaccination have been recommended to avoid co‐infections between influenza viruses and SARS‐CoV‐2. Scattered reports suggested a protective effect of influenza vaccine on COVID‐19 development and severity. We analyzed 51 studies on the capacity of influenza vaccination to affect infection with SARS‐CoV‐2, hospitalization, admission to Intensive Care Units (ICU), and mortality. All subjects taken into consideration did not receive any anti‐SARS‐CoV‐2 vaccine, although their status with respect to previous infections with SARS‐CoV‐2 is not known. Comparison between vaccinated and not‐vaccinated subjects for each of the four endpoints was expressed as odds ratio (OR), with 95% confidence intervals (CIs); all analyses were performed by DerSimonian and Laird model, and Hartung‐Knapp model when studies were less than 10. In a total of 61 029 936 subjects from 33 studies, influenza vaccination reduced frequency of SARS‐CoV‐2 infection [OR plus 95% CI = 0.70 (0.65−0.77)]. The effect was significant in all studies together, in health care workers and in the general population; distance from influenza vaccination and the type of vaccine were also of importance. In 98 174 subjects from 11 studies, frequency of ICU admission was reduced with influenza vaccination [OR (95% CI) = 0.71 (0.54−0.94)]; the effect was significant in all studies together, in pregnant women and in hospitalized subjects. In contrast, in 4 737 328 subjects from 14 studies hospitalization was not modified [OR (95% CI) = 1.05 (0.82−1.35)], and in 4 139 660 subjects from 19 studies, mortality was not modified [OR (95% CI) = 0.76 (0.26−2.20)]. Our study emphasizes the importance of influenza vaccination in the protection against SARS‐CoV‐2 infection.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

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Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis

Pontiroli,

Scovenna,

Carlini

et al. 2024

Journal of Medical Virology

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“…Tampoco se han tenido en cuenta los tratamientos administrados durante el ingreso hospitalario, por su heterogeneidad y escaso nivel de evidencia en estudios publicados [ 28 ]. Adicionalmente, la situación epidemiológica puede haber condicionado los criterios de ingreso y disponibilidad de camas y haber influido en los resultados de mortalidad [ 29 ].…”

Section: Discussionunclassified

Epidemiological study on the impact of influenza vaccination on the clinical course of patients with COVID-19 and co-infection by both viruses in Gran Canaria, Spain

Bilbao¹,

Fernández²,

Francés³

et al. 2023

Rev Esp Quimioter

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Objectives. To analyze the frequency of influenza and SARS-CoV-2 co-infections, as well as the differences in the course of disease (risk of mortality, hospital and intensive care admissions) in patients infected with the SARS-CoV-2 virus in relation to flu vaccination status in the 2021-2022 season. Methodology. Population-based observational retrospective study in a cohort of 19,850 patients diagnosed with COVID-19 between June 1, 2021 and February 28, 2022 on the island of Gran Canaria. Results. A total of 1,789 patients (9%) diagnosed with COVID-19 had received flu vaccinations. 13,676 people (68.9%) had a full course of COVID-19 vaccinations. In the period between June 1, 2021 and February 28, 2022, 8 cases of flu and COVID-19 coinfection were recorded. Hypertension (18.5%), asthma (12.8%) and diabetes (7.2%) were the most frequent comorbidities. There were 147 deaths (0.7%). Older patients ([OR] 1.11 95% CI 1.09-1.13) and people with cancer ([OR] 4.21 95% CI 2.58-6.89) had a higher risk of dying from COVID-19 (p<0.05). Female sex was noted as a protective factor ([OR] 0.61 95% CI 0.40-0.92). Conclusions. Old age, male sex and cancer were independent prognostic factors for mortality. Three doses of SARS-CoV-2 vaccines and influenza vaccines were highly effective in preventing COVID-19-related deaths and hospital admissions. These findings suggest that flu vaccination can help control the pandemic.

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“…Although controversial, the influenza vaccine may protect against adverse conditions seen in COVID-19 disease. Although some studies find the influenza vaccine ineffective [ [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] ], many studies support that the vaccine reduces the risk of morbidity and mortality due to COVID-19 infection [ 5 , [27] , [28] , [29] , [30] , [31] , [32] ].…”

Section: Discussionmentioning

confidence: 99%

Influenza and pneumococcal vaccination and COVID-19 in kidney transplant patients

Satir¹,

Demirci²,

Öztürk³

2022

Transplant Immunology

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Influence of influenza vaccine and comorbidity on the evolution of hospitalized COVID-19 patients⋆

Cited by 4 publications

References 9 publications

Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis

Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis

Epidemiological study on the impact of influenza vaccination on the clinical course of patients with COVID-19 and co-infection by both viruses in Gran Canaria, Spain

Influenza and pneumococcal vaccination and COVID-19 in kidney transplant patients

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