Influence of inflammatory response, infection, and pulmonary function in cystic fibrosis

Pereira, Leticia Cristina Radin; Moreira, Emília Addison Machado; Bennemann, Gabriela Datsch; Moreno, Yara Maria Franco; Buss, Ziliani da Silva; Barbosa, Eliana; Ludwig-Neto, Norberto; Filho, Danilo Wilhelm; Fröde, Tânia Sílvia

doi:10.1016/j.lfs.2014.06.002

Cited by 16 publications

(14 citation statements)

References 32 publications

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“…As expected (and in accordance with previous studies in this field), the patients had significantly higher levels of RCP, IL-6, and TNF-α than the controls, despite being in a clinically stable state [25,26]. These data support the hypothesis that there is a state of subclinical inflammation associated with CF that can be measured systemically [27,28].…”

Section: Discussionsupporting

confidence: 91%

Inflammation and Oxidation Biomarkers in Patients with Cystic Fibrosis: The Influence of Azithromycin

Olveira¹,

Padilla²,

Dorado³

et al. 2017

Eurasian J Med

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Objective: In addition to their antibiotic effect, macrolides appear to modulate the inflammatory response in cystic fibrosis (CF) and could influence oxidative stress. The objective of this study was to assess oxidation biomarkers and levels of inflammation and to determine whether there is an association between these parameters and the intake of macrolides. Materials and Methods:The subjects included in this cross-sectional study were, on the one hand, clinically stable patients with CF and, on the other, healthy controls. The following serum and plasma inflammatory and oxidative stress biomarkers were measured: interleukin-6 (IL-6), reactive C protein (RCP), tumor necrosis alpha (TNF-α), glutathione peroxidase (GPx), total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD), together with markers of lipid peroxidation (8-isoprostanes and thiobarbituric acid reactive substances [TBARS]). Clinical, anthropometric, lung function, radiological, and analytical variables (albumin, prealbumin, vitamins, and zinc) were also recorded. Results:We studied 36 adults with CF and 41 controls. No differences were observed in age, gender, or anthropometric variables. The patients had significantly higher levels of IL-6, TNF-α, RCP, TBARS, and isoprostanes, and lower levels of SOD than the controls. Twenty-three of the patients were treated with azithromycin, and they had more severe clinical and radiological parameters than those who were not but nevertheless presented significantly lower levels of TNF-α. No differences were observed in the markers of oxidation.Conclusion: Inflammation and oxidation biomarkers were increased in patients with CF compared with controls. The use of azithromycin was associated with reduced TNF-α levels and did not influence oxidation parameters.

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Section: Discussionsupporting

confidence: 91%

Inflammation and Oxidation Biomarkers in Patients with Cystic Fibrosis: The Influence of Azithromycin

Olveira¹,

Padilla²,

Dorado³

et al. 2017

Eurasian J Med

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“…Although there are several potential blood-based biomarkers for monitoring CF subjects and to identify those who are at a risk of acute pulmonary exacerbation, none of them, as yet, have been integrated into routine clinical practice 37 . Serum MPO, IL-1β, and CRP 15 , plasma soluble CD14 16 , and plasma IL-8 17 can predict pulmonary exacerbation effectively, but only at early time points. No significant association between CRP and the severity index of the disease was observed 38 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous reports discussed the potential role of CRP in the prediction and detection of pulmonary exacerbations with relatively good efficacy 15,17,38 . However, this parameter has yet to become a routinely used examination in CF.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The clinical course of CF could then be indirectly assessed using e.g., increased serum concentrations of the C-reactive protein (CRP), interleukin (IL)-1β, and myeloperoxidase 14 that is linked to neutrophilia 15 , while the measurement of plasma soluble CD14 16 , as well as CRP and plasma IL-8 17 concentrations might be predictive of pulmonary exacerbations. Cytokine concentrations were also thoroughly analyzed in the bronchoalveolar lavage fluid (BALF) 9,18 and in sputum samples from CF patients 19 .…”

Section: Introductionmentioning

confidence: 99%

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Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic Fibrosis

Nagy

Fila

Clarke

et al. 2016

Chest

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“…Although CF is a chronic disease affecting many organs, the lung manifestations are still today the major cause of morbidity and mortality of these individuals and are the consequences of an ongoing inflammatory process, which stems either in the absence or in the presence of opportunistic bacterial infections. Lung inflammation and respiratory infections affect the prognosis of CF patients [3,4]; indeed, they are associated with the progressive destructive changes that are responsible for most of the morbidity and mortality in CF [5]. Over 1000 microbial species (viruses, bacteria, mould, and fungi) have been found in the airways of CF patients [6].…”

Section: Introductionmentioning

confidence: 99%

Role of Neutrophils in Cystic Fibrosis Lung Disease

Conese¹,

Castellani²,

D’Oria³

et al. 2017

Role of Neutrophils in Disease Pathogenesis

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Cystic fibrosis (CF) is a genetic syndrome caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene. In CF patients, chief morbidity and mortality are due to pulmonary manifestations. CFTR lack/dysfunction brings an altered ion flux through the airway epithelium and ablation of mucociliary clearance, which in turn ensues in colonization and infection by opportunistic bacterial pathogens and subsequent neutrophil-dominated inflammation. This response eventually leads to the damage of the lung tissue. A host of inflammatory mediators attract, activate, and reprogramme neutrophils to survive (avoiding apoptosis) and produce a wealth of proteases and radical oxygen species. The protease/antiprotease imbalance and oxidative stress have multiple downstream effects, including impaired mucus clearance, increased and self-perpetuating inflammation, and impaired immune responses, thus facilitating and fostering bacterial infections. On the other hand, CFTR lack or dysfunction is likely responsible for alterations in neutrophils concerning chemotaxis, phagocytosis, oxidative burst, degranulation, and neutrophil extracellular trap (NET) formation. A good opportunity to reveal new and non-invasive biomarkers of CF lung disease is the evaluation of circulating neutrophils. Indeed, neutrophil responses are now investigated as outcomes of the aetiological therapies in CF, such as hypertonic saline, antiproteases, CFTR correctors and potentiators.

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Influence of inflammatory response, infection, and pulmonary function in cystic fibrosis

Cited by 16 publications

References 32 publications

Inflammation and Oxidation Biomarkers in Patients with Cystic Fibrosis: The Influence of Azithromycin

Inflammation and Oxidation Biomarkers in Patients with Cystic Fibrosis: The Influence of Azithromycin

Human Epididymis Protein 4: A Novel Serum Inflammatory Biomarker in Cystic Fibrosis

Role of Neutrophils in Cystic Fibrosis Lung Disease

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