Influence of inflammation on parasitism and area of experimental amoebic liver abscess: an immunohistochemical and morphometric study

Costa, Camila Adriana Barbosa; Fonseca, Thaisa Helena Silva; Oliveira, Fabrício Marcus Silva; Santos, Joseph Fabiano Guimarães; Gomes, Maria Aparecida; Caliari, Marcelo Vidigal

doi:10.1186/1756-3305-4-27

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…Regarding the virulence and pathogenicity inherent to each species, antibodies, complement, macrophages, and neutrophils seem to interfere in the selection of more resistant trophozoites and in the development of amebic liver abscesses. [ 54 55 ]…”

Section: Introductionmentioning

confidence: 99%

Entamoeba dispar: Could it be pathogenic

et al. 2015

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Amebiasis is a disease caused by the protozoan parasite Entamoeba histolytica. This ameba can colonize the human intestine and persist as a commensal parasite, similar to Entamoeba dispar, an ameba considered to be non-pathogenic. The similarities between E. histolytica and E. dispar make the latter an attractive model for studies aimed at clarifying the pathogenesis of amebiasis. However, in addition to being an interesting experimental model, this relative of E. histolytica remains poorly understood. In the 1990, it was believed that E. dispar was unable to produce significant experimental lesions. This scenario began to change in 1996, when E. dispar strains were isolated from symptomatic patients in Brazil. These strains were able to produce liver and intestinal lesions that were occasionally indistinguishable from those produced by E. histolytica. These and other findings, such as the detection of E. dispar DNA sequences in samples from patients with amebic liver abscess, have revived the possibility that this species can produce lesions in humans. The present paper presents a series of studies on E. dispar that begin to reveal a new facet of this protozoan.

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Section: Introductionmentioning

confidence: 99%

Entamoeba dispar: Could it be pathogenic

et al. 2015

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“…Islands of better preserved liver tissue were also seen scattered among the necrotic foci. Moreover, serum sample could easily be obtained from [5][6][7] days post-infected hamster, and contained sufficient polyclonal antibodies that recognize E. histolytica trophozoites [20] .…”

Section: Discussionmentioning

confidence: 99%

“…Contents lists available at ScienceDirect followed by extensive necrosis with fused granulomas [7][8][9] .…”

Section: Pas Ihc Trophozoitementioning

confidence: 99%

Detection of Entamoeba histolytica in experimentally induced amoebic liver abscess: comparison of three staining methods

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Mustafa

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…All analyses were performed with a Nikon Eclipse microscope using 10×, 40×, and 100× planachromatic objectives for transmitted light microscopy and birefringent lenses for polarized light microscopy. In addition, inflammatory cell number were analyzed and calculated as the mean of four regions in each H.E.‐stained histological section similar to Costa et al (2011). The microscope was coupled to the SD‐3.3 CCD image acquisition system of the Department of Morphology and Basic Pathology, Faculty of Medicine of Jundiaí.…”

Section: Methodsmentioning

confidence: 99%