Influence of immune inflammation on androgen receptor expression in benign prostatic hyperplasia tissue

Wu, Zong-Lin; Yuan, Yunbin; Geng, He; Xia, Shujie

doi:10.1038/aja.2011.154

Cited by 30 publications

(25 citation statements)

References 21 publications

(24 reference statements)

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“…24,25,26 Prostate specimens displaying inflammation have also been shown to have higher expression of the androgen receptor. 27 Ripple et al demonstrated that androgens can result in oxidative stress in prostate cancer cells. 28 Interestingly, androgen receptor levels have been shown to be elevated in PCa found in younger individuals.…”

Section: Discussionmentioning

confidence: 99%

Aspirin and NSAID use in association with molecular subtypes of prostate cancer defined by TMPRSS2:ERG fusion status

Wright

Chéry

Holt

et al. 2015

Prostate Cancer Prostatic Dis

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Background The TMPRSS2:ERG (T2E) gene fusion is the most common rearrangement in prostate cancer (PCa). It is unknown if these molecular subtypes have a different etiology. We evaluated aspirin and non-aspirin NSAIDs in association with T2E fusion status. Methods Subjects were from a population-based case-control study of PCa. T2E fusion status for prostatectomy cases (n=346) was determined by FISH. Medication use was determined from questionnaires. Logistic regression, controlling for age, race, PCa family history, and PSA screening, was used to evaluate the association of T2E fusion status according to medication use. Results T2E fusion was present in 171 (49%) cases, with younger cases more likely to be fusion positive (p<0.01). Current aspirin use was associated with a 37% risk reduction of T2E positive tumors (adjusted OR 0.63, 95% CI 0.43–0.93). Aspirin use was not associated with T2E negative PCa (adjusted OR 0.99, 0.69–1.42). There were no associations between PCa fusion status and use of non-aspirin NSAIDs or acetaminophen. Conclusion Aspirin is associated with a significant reduction in the relative risk of T2E fusion positive, but not T2E negative, PCa. Since inflammation and androgen pathways are implicated in prostate carcinogenesis, additional studies of anti-inflammatory medications in relation to these PCa subtypes are warranted.

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Section: Discussionmentioning

confidence: 99%

Aspirin and NSAID use in association with molecular subtypes of prostate cancer defined by TMPRSS2:ERG fusion status

Wright

Chéry

Holt

et al. 2015

Prostate Cancer Prostatic Dis

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“…This study showed that activation of NF-κB pathway by neuroendocrine secretory proteins could sustain androgen independent growth of PCa by regulating AR. One of the other reports studying inflammation in benign prostate hyperplasia patients showed that patients having potent immune inflammation had larger volumes of prostate, increased AR and serum PSA levels [ 135 ]. ADT in mice activates an inflammatory response by the dying PCa cells causing the permeation of B and T cells [ 136 ].…”

Section: Interplay Between Nrf-2-antioxidant Nf-κb Inflammatory Amentioning

confidence: 99%

Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer

Khurana

Sikka

2018

Cancers

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Oxidative stress, inflammation and androgen receptor (AR) signaling play a pivotal role in the initiation, development and progression of prostate cancer (PCa). Numerous papers in the literature have documented the interconnection between oxidative stress and inflammation; and how antioxidants can combat the inflammation. It has been shown in the literature that both oxidative stress and inflammation regulate AR, the key receptor involved in the transition of PCa to castration resistant prostate cancer (CRPC). In this review, we discuss about the importance of targeting Nrf-2-antioxidant signaling, NF-κB inflammatory response and AR signaling in PCa. Finally, we discuss about the crosstalk between these three critical pathways as well as how the anti-inflammatory antioxidant phytochemicals like sulforaphane (SFN) and curcumin (CUR), which can also target AR, can be ideal candidates in the chemoprevention of PCa.

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“…Thus, it is possible that systemic inflammatory mediators and oxidative stress related to obesity promote prostate growth. Wu et al 25 reported that prostate hyperplasia caused by an immune inflammatory process might contribute to BPH progression. Another possible explanation is that sex steroid hormone levels change due to obesity.…”

Section: Discussionmentioning

confidence: 99%

A novel equation and nomogram including body weight for estimating prostate volumes in men with biopsy-proven benign prostatic hyperplasia

Nakanishi

Masuda²,

Kawakami³

et al. 2012

Asian J Androl

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Anthropometric measurements, e.g., body weight (BW), body mass index (BMI), as well as serum prostate-specific antigen (PSA) and percent-free PSA (%fPSA) have been shown to have positive correlations with total prostate volume (TPV). We developed an equation and nomogram for estimating TPV, incorporating these predictors in men with benign prostatic hyperplasia (BPH). A total of 1852 men, including 1113 at Tokyo Medical and Dental University (TMDU) Hospital as a training set and 739 at Cancer Institute Hospital (CIH) as a validation set, with PSA levels of up to 20 ng ml 21 , who underwent extended prostate biopsy and were proved to have BPH, were enrolled in this study. We developed an equation for continuously coded TPV and a logistic regression-based nomogram for estimating a TPV greater than 40 ml. Predictive accuracy and performance characteristics were assessed using an area under the receiver operating characteristics curve (AUC) and calibration plots. The final linear regression model indicated age, PSA, %fPSA and BW as independent predictors of continuously coded TPV. For predictions in the training set, the multiple correlation coefficient was increased from 0.38 for PSA alone to 0.60 in the final model. We developed a novel nomogram incorporating age, PSA, %fPSA and BW for estimating TPV greater than 40 ml. External validation confirmed its predictive accuracy, with AUC value of 0.764. Calibration plots showed good agreement between predicted probability and observed proportion. In conclusion, TPV can be easily estimated using these four independent predictors.

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Influence of immune inflammation on androgen receptor expression in benign prostatic hyperplasia tissue

Cited by 30 publications

References 21 publications

Aspirin and NSAID use in association with molecular subtypes of prostate cancer defined by TMPRSS2:ERG fusion status

Aspirin and NSAID use in association with molecular subtypes of prostate cancer defined by TMPRSS2:ERG fusion status

Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer

A novel equation and nomogram including body weight for estimating prostate volumes in men with biopsy-proven benign prostatic hyperplasia

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