Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer

Hellmig, Stephan; Titz, Andrea; Steinel, Stefanie; Ott, Stephan; Fölsch, Ulrich R.; Hampe, Jochen; Schreiber, Stefan

doi:10.1016/j.imlet.2005.04.001

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…Despite this effect, and different from previous reports,18,21 allele 2 had no association with the grading of gastritis of the gastric antrum and with gastric ulcer. H. pylori infection was demonstrated as an independent risk factor for histological gastritis,6 inflammation, and peptic ulcer 5,34,35…”

Section: Discussioncontrasting

confidence: 99%

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A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

Mattar¹,

Marques²,

Santos³

et al. 2013

CEG

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ObjectiveTo verify whether the variable number of tandem repeat (VNTR) polymorphism in the IL-1RN gene that encodes the interleukin (IL)-1 receptor antagonist (IL-1Ra) plays a role in the outcome of gastrointestinal diseases associated with Helicobacter pylori (H. pylori) infection.MethodsPatients with normal endoscopy (n = 71), inflammation of the upper gastrointestinal tract only (n = 196), gastric ulcer (n = 28), duodenal ulcer (n = 76), and gastric cancer (n = 19) were studied. H. pylori infection was diagnosed by the urease test, histological examination, and polymerase chain reaction. The IL-1 receptor antagonist gene (IL-1RN intron 2 VNTR) was analyzed by polymerase chain reaction. Gastritis was scored according to the updated Sydney system of classification.ResultsH. pylori infection was an independent risk factor for mild (odds ratio [OR] = 5.53 [95% confidence interval [CI] = 2.63–11.64; P < 0.05]), moderate (OR = 83.93 [95% CI = 29.7–237.18; P < 0.05]) and marked (OR = 47.47 [95% CI = 5.39–418.05; P < 0.05]) gastritis. The carriage of IL-1RN*2/*2 had a significant protective effect of H. pylori infection (OR = 0.31 [95% CI = 0.17–0.57; P < 0.05]). H. pylori infection was identified as an independent risk of inflammation, duodenal ulcer, and gastric ulcer. The carriage of IL-1RN*2/*2 was an independent risk factor for gastric cancer (OR = 5.81 [95% CI = 1.06–31.98; P < 0.05]); nonetheless, the carriage of allele 2 (IL-1RN*2/*2 plus IL-1RN*L/*2) had an independent protective effect on duodenal ulcer (OR = 0.45 [95% CI = 0.22–0.91; P < 0.05]).ConclusionsAllele 2 of the VNTR IL-1RN polymorphism had a protective effect against duodenal ulcer and H. pylori infection; however, it increased the risk of gastric cancer.

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Section: Discussioncontrasting

confidence: 99%

“…In a study conducted in Bogota, an inverse association was detected 20. Additionally, an increased risk of gastric ulcer has been reported 17,21…”

Section: Introductionmentioning

confidence: 99%

A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

Mattar¹,

Marques²,

Santos³

et al. 2013

CEG

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“…Interestingly, our results demonstrate a significantly higher IL-1␤ expression in the CT and TT genotypes compared to the CC subgroup. In accordance, the IL-1␤(3954) T allele has been associated with increased IL-1␤ production in diverse pathological conditions, such as rheumatoid arthritis and osteoarthritis, and also with an increased risk for the development of such pathologies (3,5,15,52). Indeed, CT and TT genotype patients also presented statistically higher values of mPD and CAL, suggesting that the genetic influence on the levels of IL-1␤ could be relevant to the determination of disease severity.…”

Section: Discussionmentioning

confidence: 75%

An Interleukin-1β (IL-1β) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1β in Diseased Periodontal Tissues

Ferreira¹,

Trombone

Repeke³

et al. 2008

Infect Immun

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“…It has been reported that while the levels of serum IL-1β in all HCV patients are higher in comparison with healthy adults, its levels in patients with liver cirrhosis (LC) or hepatocellular carcinoma (HCC) were higher than that in patients without LC; such high levels of IL-1β result in a lengthening of the inflammatory process in the liver and in a high replication of the HCV [29,30]. However, other studies have reported that the interleukin-1β (+3954) T allele has been associated with increased IL-1β production in diverse pathological conditions, and also with an increased risk for the development of such pathologies [31,32]. In accordance with those findings, our data showed that the percentage of interleukin-1β SNPs in different stages of the liver of chronic C patients, where the percentage of C/C genotype was the highest in lower fibrosis stages i.e.…”

Section: Discussionmentioning

confidence: 99%

Relation of interleukin-1β gene to treatment response in chronic patients infected with HCV genotype 4

Omran

Ibrahim

Youssef

et al. 2013

J Infect Dev Ctries

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Introduction: Hepatitis C virus (HCV) infection results in chronic hepatitis in more than 70% of infected patients, while 20-30% of patients recover spontaneously. This strengthens the role of the host genetic factors in either spontaneous or drug-induced viral clearance. The aim of this study was to investigate the relationship between interleukin-1β +3953 gene polymorphism and the response to interferon therapy in chronic HCV patients infected with genotype 4. Methodology: The interleukin-1β (+3953 C/T) (rs1143634) gene was amplified in 115 chronic HCV patients. Interleukin-1β single nucleotide polymorphism (SNP) plus several clinical and pathological factors were statistically analyzed in correlation with response to therapy. Results: Genotypes C/T and T/T had a significant association with non-response to treatment compared to genotype C/C, which had a strong association with response to treatment (95% confidence; 6.4884-48.5818, p = 0.0001). Furthermore, analysis of allele frequency in this cohort revealed that the T allele is associated with non-response, higher fibrosis, and higher hepatic activity, while the C allele had a significant association with sustained virologic response lower fibrosis, and lower hepatic activity (p value = 0.0001). Conclusion: This is the first study to examine the correlation between interleukin-1β (+3953 C/T) (rs1143634) gene polymorphism and the response of interferon therapy in genotype 4 HCV-infected patients. The results encourage further assessment of this SNP as a marker to predict response to therapy and disease progression, which can have major implications in saving money, time, and in avoiding unnecessary adverse effects.

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Influence of IL-1 gene cluster polymorphisms on the development of H. pylori associated gastric ulcer

Cited by 11 publications

References 34 publications

A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

An Interleukin-1β (IL-1β) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1β in Diseased Periodontal Tissues

Relation of interleukin-1β gene to treatment response in chronic patients infected with HCV genotype 4

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