A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

Mattar, Rejane; Marques, Sirlei Garcia; Santos, Anibal Ferreira dos; Monteiro, Maria do Socorro; Iriya, Kiyoshi; Carrilho, Flair José

doi:10.2147/ceg.s42260

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…Patients with dyspeptic symptoms underwent an upper endoscopy. H. pylori infection was determined by the rapid urease test [ 24 ] and histology [ 25 ], using gastric mucosal biopsies of the antrum and body. Patients with positive results in the two methods were included in the trial.…”

Section: Methodsmentioning

confidence: 99%

Standard Triple Therapy versus Sequential Therapy inHelicobacter pyloriEradication: A Double-Blind, Randomized, and Controlled Trial

Eisig

Navarro–Rodriguez

Teixeira

et al. 2015

Gastroenterology Research and Practice

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Aim. To compare 10-day standard triple therapy versus sequential therapy as first-line treatment in patients infected with H. pylori. Methods. One hundred H. pylori positive patients (diagnosed by rapid urease test and histology), with average age of 47.2, M/F = 28/72, were randomized to receive either standard triple treatment (TT) as follows: lansoprazole 30 mg, clarithromycin 500 mg, and amoxicillin 1 g, b.i.d. for ten days, or sequential treatment (ST) as follows: lansoprazole 30 mg, amoxicillin and placebo 1.0 g b.i.d for the first five days, followed by lansoprazole 30 mg, clarithromycin 500 mg, and tinidazole 500 mg b.i.d, for the remaining five days. Eradication rates were determined 60 days after treatment by urease, histology, or 13C-urea breath test. Results. In intention to treat (ITT) analysis, the rate of H. pylori eradication in the TT and ST groups was the same for both regimens as follows: 86% (43/50), 95% CI 93,3 to 73.4%. In Per protocol (PP) analysis, the rate of H. pylori eradication in the TT and ST groups was 87.8% (43/49), 95% CI 94,5 to 75.3% and 89.6% (43/48), 95% CI 95,8 to 77.3%, respectively. Conclusions. In Brazil, standard triple therapy is as equally effective as sequential therapy in eradicating Helicobacter pylori patients. This study was registered under Clinical Trials with number ISRCTN62400496.

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Section: Methodsmentioning

confidence: 99%

Standard Triple Therapy versus Sequential Therapy inHelicobacter pyloriEradication: A Double-Blind, Randomized, and Controlled Trial

Eisig

Navarro–Rodriguez

Teixeira

et al. 2015

Gastroenterology Research and Practice

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“…IL-1rα can influence IL-1β levels, and some studies have focused on the relationship between IL-1RN VNTR polymorphism and H . pylori infection related-diseases [46, 47]. Others have investigated the association between IL-1RN VNTR polymorphism and H .…”

Section: Discussionmentioning

confidence: 99%

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

Zhang¹,

Sun²,

Wang³

et al. 2017

PLoS ONE

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The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat (VNTR) polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios (ORs) with 95% confidence intervals (CIs). A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL (OR = 1.17, 95% CI = 1.02–1.33) and 2 allele vs. L allele (OR = 1.18, 95% CI = 1.00–1.40). Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and Hospital-Based subgroup (i.e., study samples obtained from hospital inpatients). In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.

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“…Gastric biopsy samples from the antrum and corpus were fixed in 10% formalin and stained with hematoxylin and eosin (H&E) and Giemsa for H. pylori identification, as was previously described (23) .…”

Section: Histologymentioning

confidence: 99%

Low Dose Capsule Based 13c-Urea Breath Test Compared With the Conventional 13c-Urea Breath Test and Invasive Tests

Mattar

Villares

Marostegam

et al. 2014

Arq. Gastroenterol.

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-Context-One of the limitations of 13 C-urea breath test for Helicobacter pylori infection diagnosis in Brazil is the substrate acquisition in capsule presentation. Objectives-The purpose of this study was to evaluate a capsule-based 13 C-urea, manipulated by the Pharmacy Division, for the clinical practice. Methods-Fifty patients underwent the conventional and the capsule breath test. Samples were collected at the baseline and after 10, 20 and 30 minutes of 13 C-urea ingestion. Urease and histology were used as gold standard in 83 patients. Results-In a total of 50 patients, 17 were positive with the conventional 13 C-urea (75 mg) breath test at 10, 20 and 30 minutes. When these patients repeated breath test with capsule (50 mg), 17 were positive at 20 minutes and 15 at 10 and 30 minutes. The relative sensitivity of 13 C-urea with capsule was 100% at 20 minutes and 88.24% at 10 and at 30 minutes. The relative specificity was 100% at all time intervals. Among 83 patients that underwent capsule breath test and endoscopy the capsule breath test presented 100% of sensitivity and specificity. Conclusion-Capsule based breath test with 50 mg 13 C-urea at twenty minutes was found highly sensitive and specific for the clinical setting. HEADINGS-Helicobacter pylori. Breath Test. Urea, analysis.

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A possible role of IL-1RN gene polymorphism in the outcome of gastrointestinal diseases associated with H. pylori infection

Cited by 8 publications

References 37 publications

Standard Triple Therapy versus Sequential Therapy inHelicobacter pyloriEradication: A Double-Blind, Randomized, and Controlled Trial

Standard Triple Therapy versus Sequential Therapy inHelicobacter pyloriEradication: A Double-Blind, Randomized, and Controlled Trial

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

Low Dose Capsule Based 13c-Urea Breath Test Compared With the Conventional 13c-Urea Breath Test and Invasive Tests

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