Influence of hypoxia and acidity on thermal radiosensitization and direct heat-induced death of BP-8 sarcoma cells.

Mivechi, Nahid F.; Hofer, Kurt G.; Hofer, Maria G.

doi:10.1148/radiology.138.2.7455132

Cited by 7 publications

(1 citation statement)

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“…Synergistic effects relating to cell death and antiproliferative effects have been described for several carcinoma cell lines in vitro [27][28][29][30]. The same was found for sarcomas [31]. DNA-double-strand-break-repair inhibition has been identified as an intracellular mechanism of enhanced radiosensitivity in combination with hyperthermia [32].…”

Section: Discussionmentioning

confidence: 96%

MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients

Unsoeld

Lamprecht

Traub

et al. 2020

Cancers

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Background: There is a strong biologic rationale for using locoregional hyperthermia in soft tissue sarcoma and a randomized trial reported significant improvements with hyperthermia. The aim of this study was to describe the opportunities of magnetic resonance (MR)-based thermometry in a cohort of soft tissue sarcoma patients undergoing combined radiotherapy and locoregional hyperthermia. Patients and Methods: For eleven evaluable patients, tumor volume (VTu) and a separate volume for temperature analysis with reliable temperature distribution (Vtherm) were contoured for every hyperthermia treatment (103 therapies). Temperature data were recorded for all tumors and were correlated with clinical features and pathologic response data. Results: Of 48 patients with high-risk soft tissue sarcomas treated with radio(chemo)therapy and locoregional hyperthermia, MR thermometry was possible in 11 (23%) patients. For all patients, the temperature superseded by 90% of VTu (T90(VTu)) and T90 (Vtherm) were in the range of 37–43 °C and 40–45 °C, respectively. Larger tumors tended to reach higher temperatures. For tumors showing a pathologic response in the resection specimen after preoperative treatment, temperature (T90 (Vtherm)) was significantly higher than in tumors without pathologic response. Conclusion: Lower extremity sarcomas undergoing preoperative treatment with locoregional hyperthermia are especially suitable for MR thermometry. MR thermometry is a promising non-invasive way for temperature measurement during locoregional hyperthermia, showing a positive dose-response relationship.

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Section: Discussionmentioning

confidence: 96%

MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients

Unsoeld

Lamprecht

Traub

et al. 2020

Cancers

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Evidence for separate modes of action in thermal radiosensitization and direct thermal cell death

Mivechi¹,

Hofer²

1983

Cancer

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It is not known whether heat potentiation of radiation damage and direct heat death are mediated by the same or by different heat lesions within the cell. In this study, three types of experiments were performed on BP‐8 murine sarcoma cells to provide evidence against a common mode of action: (1)Evaluation of the kinetics of cell death from heat, radiation, and combined heat‐radiation treatments: direct heat death is rapid and essentially complete within 24‐48 hours after heat exposure, whereas radiation death develops only after a delay period of several days. Radiosensitization by heat affects only the delayed component of cell death, that is, the radiation component of death. (2)Thermal radiosensitization and direct heat death as a function of heating time: thermal radiosensitization requires only short exposures to heat; prolonged heating does not further enhance this effect. In contrast, direct heat death increases with increasing duration of heat exposure. (3)Independent modification of radiosensitization and thermal death: addition of 5% glycerol to the incubation medium protects cells against direct heat death, but not against thermal radiosensitization. In combination, these findings suggest that heat potentiation of radiation lethality and direct heat death are two distinct phenomena mediated by different cellular mechanisms.

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Significance of additive heat effect in the therapeutic gain factor in combined hyperthermia and radiotherapy: Murine tumor response and foot reaction

Sougawa

Urano

1991

International Journal of Radiation Oncology*Biology*Physics

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Influence of hypoxia and acidity on thermal radiosensitization and direct heat-induced death of BP-8 sarcoma cells.

Cited by 7 publications

References 0 publications

MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients

MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients

Evidence for separate modes of action in thermal radiosensitization and direct thermal cell death

Significance of additive heat effect in the therapeutic gain factor in combined hyperthermia and radiotherapy: Murine tumor response and foot reaction

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