Influence of Hyperbaric Oxygenation and Antioxidant Therapy on Oxidative Metabolism in Patients With Burns

Abstract

The aim of the work was to assess the state of oxidative blood metabolism in patients with burns in the dynamics of the use of antioxidant therapy and hyperbaric oxygenation. The study included 25 patients with I-II-III degree burns of various localization (lesion area - over 25% of the body surface), randomized into 3 groups: standard therapy (n=10); addition of standard therapy with antioxidants (n=10); use of the combination "antioxidants – hyperbaric oxygenation (n=5)". It was found that the combined use of hyperbaric oxygenation and antioxidants in burn victims makes it possible to most effectively stop signs of oxidative stress, as indicated by a decrease in the intensity of free radical oxidation against the background of an increase in antioxidant potential (total antioxidant activity, glutathione reductase activity).