Influence of Hydroxyapatite on Extruded 3D Scaffolds

Rodriguez, Geraldine N.; Dias, Juliana R.; d’Ávila, Marcos Akira; Bartolo, Paulo Jorge Da Silva

doi:10.1016/j.proeng.2013.05.120

Cited by 28 publications

(18 citation statements)

References 9 publications

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“…It has been widely used for bone and cartilage potential applications due to its mechanical properties . However, its hydrophobicity can affect cell adhesion and proliferation . Therefore, PCL composites and polymer blends have been fabricated to improve the scaffolds performance.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of PCL/β‐TCP scaffolds by 3D mini‐screw extrusion printing

Dávila

Freitas

Neto

et al. 2015

J of Applied Polymer Sci

112

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Scaffolds of polycaprolactone (PCL) and PCL composites reinforced with b-tricalcium phosphate (b-TCP) were manufactured aiming potential tissue engineering applications. They were fabricated using a three-dimensional (3D) mini-screw extrusion printing, a novel additive manufacturing process, which consists in an extrusion head coupled to a 3D printer based on the Fab@Home equipment. Thermal properties were obtained by differential scanning calorimetry and thermogravimetric analyses. Scaffolds morphology were observed using scanning electron microscopy and computed microtomography; also, reinforcement presence was observed by X-ray diffraction and the polymer chemical structure by Fourier transform infrared spectroscopy. Mechanical properties under compression were obtained by using a universal testing machine and hydrophilic properties were studied by measuring the contact angle of water drops. Finally, scaffolds with 55% of porosity and a pore size of 450 lm have shown promising mechanical properties; the b-TCP reinforcement improved mechanical and hydrophilic behavior in comparison with PCL scaffolds. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43031.

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Section: Introductionmentioning

confidence: 99%

Fabrication of PCL/β‐TCP scaffolds by 3D mini‐screw extrusion printing

Dávila

Freitas

Neto

et al. 2015

J of Applied Polymer Sci

112

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“…That gives HA the potential to be used as a structural biomaterial in multidirectional load-bearing applications [16]. What is more, HA is fully compatible with rapid prototyping technologies, and researchers have employed it in order to produce scaffolds for bone tissue engineering from such techniques [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

3D printing-assisted design of scaffold structures

Kantaros

Chatzidai

Karalekas

2015

Int J Adv Manuf Technol

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Rapid prototyping has emerged as a very auspicious manufacturing method of fabricating tissue engineering scaffolds. Using a 3D CAD design, the 3D printer features the ability of producing the predetermined forms and structures with very high level of accuracy and repeatability. Additionally, the 3D-printed tissue scaffolds are meant to act as replaceable constructs in a very demanding environment. The challenging conditions of the human body set high criteria demands that the scaffold should be capable of fulfilling. One of the most crucial demands is the capability of the scaffold to exhibit the desired mechanical properties depending on the loading conditions that it must cope up against. A mechanical property investigation of different scaffold designs can provide crucial information concerning this key factor in the criteria profile of a functional scaffold design. The target of the present study is to compare the mechanical properties of different scaffold designs that, however, feature same porosity and similar dimensions. Compressive strength testing was conducted in three 3D-printed scaffold designs. Also, a finite element study was conducted, simulating the compressive strength testing. The results of the compression testing experiment were found to be in good agreement with the computational analysis results. Furthermore, a computational fluid dynamic (CFD) simulation was conducted in order to look into the fluid shear stress inside the scaffold. Finally, the properties of the biomaterial hydroxyapatite were used in order to investigate the compressive and shear mechanical behavior of the aforementioned designs by conducting a finite element study.

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“…Because calcium phosphate takes forms of varying complexity, bulk materials provide a convenient method of studying their effects in tissue engineering. However, bulk modifications also significantly affect mechanical properties of the scaffold, usually increasing hardness and brittleness (Rodriguez, Dias, d'Ávila, & Bártolo, 2013). They also require more specialized manufacturing techniques because the crystalline particles degrade typical polyester 3D printing and molding devices.…”

Section: Mineral Depositionmentioning

confidence: 99%

Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

Richbourg

Peppas

Sikavitsas

2019

J Tissue Eng Regen Med

149

115

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Tissue engineering and regenerative medicine rely extensively on biomaterial scaffolds to support cell adhesion, proliferation, and differentiation physically and chemically in vitro and in vivo. Changes to the surface characteristics of the scaffolds have the greatest impact on cell response. Here, we discuss five dominant surface modification approaches used to biomimetically improve the most common scaffolds for tissue engineering, those based on aliphatic polyesters. Scaffolds of aliphatic polyesters such as poly(L-lactic acid), poly(L-lactic-co-glycolic acid), and poly(ε-caprolactone) are often used in tissue engineering because they provide desirable, tunable properties such as ease of manufacturing, good mechanical properties, and nontoxic degradation products. However, cell–surface interactions necessary for tissue engineering are limited on these materials by their smooth postfabrication surfaces, hydrophobicity, and lack of recognizable biochemical binding sites. The surface modification techniques that have been developed for synthetic polymer scaffolds reduce initial barriers to cell adhesion, proliferation, and differentiation. Topographical modification, protein adsorption, mineral coating, functional group incorporation, and biomacromolecule immobilization each contribute through varying mechanisms to improving cell interactions with aliphatic polyester scaffolds. Furthermore, rational combination of methods from these categories can provide nuanced, specific environments for targeted tissue development.

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Influence of Hydroxyapatite on Extruded 3D Scaffolds

Cited by 28 publications

References 9 publications

Fabrication of PCL/β‐TCP scaffolds by 3D mini‐screw extrusion printing

Fabrication of PCL/β‐TCP scaffolds by 3D mini‐screw extrusion printing

3D printing-assisted design of scaffold structures

Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

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