Influence of hyaluronic acid on wound healing using composite porcine acellular dermal matrix grafts and autologous skin in rabbits

Zhao, Jingyu; Chai, Jiake; Song, Haixing; Zhang, Jin; Xu, Min; Liang, Yue-Dan

doi:10.1111/j.1742-481x.2012.01023.x

Cited by 26 publications

(28 citation statements)

References 18 publications

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“…24 Contraction was also significantly reduced in a rabbit model when an acellular porcine dermal matrix with hyaluronic acid (HA) was applied in combination with STSG, in comparison with the dermal matrix without HA or STSG alone. 11 The authors further noted that collagen deposition in the wounds treated with HA more closely resembled that of normal skin, compared with other wounds, and that vascularization of the grafts was improved.…”

Section: Discussion Of Findings and Relevant Literature Tissue-enginementioning

confidence: 94%

“…10,22 Other natural materials, such as amniotic membrane and acellular porcine dermal matrix, have further shown therapeutic potential in vivo. 11,23,24 A comparison between human amniotic membrane and IntegraÔ, both in combination with STSG, applied to Berlin minipigs showed a reduction in contraction in amniotic membrane-treated wounds at 60 days postsurgery. This was accompanied by a delay in the appearance of myofibroblasts in the tissue.…”

Section: Discussion Of Findings and Relevant Literature Tissue-enginementioning

confidence: 99%

“…8 Morris et al 9 first described the rabbit ear excision model, which displays raised scars reminiscent of hypertrophic scars in humans, but does not heal by contraction. Others have since used other sites on the rabbit for evaluation of treatments for full-thickness skin defects, 10,11 where contraction does occur. Pig skin has similar physiological, anatomical, and biochemical properties to human skin.…”

Section: Wound Contraction In Animal Modelsmentioning

confidence: 99%

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Strategies Demonstrating Efficacy in Reducing Wound ContractionIn Vivo

Sharpe

Martin

2013

Advances in Wound Care

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Significance: Scarring continues to present a significant clinical problem. Wound contraction leads to scarring and is mediated by myofibroblasts and contractile forces across the wound bed. Contracture formation can have a significant impact on the quality of life of the patient, particularly where function and appearance are affected. Recent Advances: Novel tissue-engineered matrices, cell-based therapies, and medicinal therapeutics have shown significant reduction in wound contraction in in-vivo models, particularly at early time points. These have been accompanied in many cases by reduced numbers of myofibroblasts, and in some by increased angiogenesis and improved neodermal architecture. Critical Issues: There are no animal models that replicate all aspects of wound healing as seen in patients. Therefore, information obtained from in vivo studies should be assessed critically. Additional studies, in particular those that seek to elucidate the mechanisms by which novel therapies reduce contraction, are needed to gain sufficient confidence to move into clinical testing. Future Directions: The use of knockout mouse models in particular has generated significant advances in knowledge of the mechanisms behind myofibroblast conversion and other factors involved in generating tension across the wound. Medicinal therapeutics and tissue-engineering approaches that seek to disrupt/alter these pathways hold much promise for future development and translation to clinical practice. SCOPEFull-thickness wounds heal with scarring, due to the abnormal arrangement of de novo collagen fibres in the neodermis and contractile forces exerted on the wound environment and surrounding tissue. Scar formation can have a negative impact on the patient and continues to present a significant clinical challenge. In vivo models take into account the physiological response to injury and the complex interactions that occur during wound repair that cannot be replicated in vitro. This review summarizes recent in vivo studies that have demonstrated efficacy in reducing wound contraction in model organisms. TRANSLATIONAL RELEVANCEThe demonstration of efficacy in vivo of a potential therapy to reduce wound contraction provides strong evidence of potential clinical efficacy. Further investigation and investment can then be undertaken to translate the novel therapy to early-stage clinical studies. In some cases, the manipulation, through the application of novel wound therapies, of the complex cascade of events leading to wound repair may have

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Section: Discussion Of Findings and Relevant Literature Tissue-enginementioning

confidence: 94%

Section: Discussion Of Findings and Relevant Literature Tissue-enginementioning

confidence: 99%

Section: Wound Contraction In Animal Modelsmentioning

confidence: 99%

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Strategies Demonstrating Efficacy in Reducing Wound ContractionIn Vivo

Sharpe

Martin

2013

Advances in Wound Care

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“…It can reduce graft contracture during skin healing by stimulating the production of more CD44 receptors, which advance the local enzymolysis of HA and promote wound surface vascularization. After the addition of HA during skin healing, the expressions of collagen I and III increase, while the ratio of the two collagen types decreases [35]. Further, in contrast to high-molecular-weight HA, low-molecular-weight HA promotes angiogenesis and granulated tissue formation [36].…”

Section: Scaffolds From Natural Polymersmentioning

confidence: 99%

Progress in development of bioderived materials for dermal wound healing

Huang

Xie

2017

Regenerative Biomaterials

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Treatment of acute and chronic wounds is one of the primary challenges faced by doctors. Bioderived materials have significant potential clinical value in tissue injury treatment and defect reconstruction. Various strategies, including drug loading, addition of metallic element(s), cross-linking and combining two or more distinct types of materials with complementary features, have been used to synthesize more suitable materials for wound healing. In this review, we describe the recent developments made in the processing of bioderived materials employed for cutaneous wound healing, including newly developed materials such as keratin and soy protein. The focus was on the key properties of the bioderived materials that have shown great promise in improving wound healing, restoration and reconstruction. With their good biocompatibility, nontoxic catabolites, microinflammation characteristics, as well as their ability to induce tissue regeneration and reparation, the bioderived materials have great potential for skin tissue repair.

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“…During the past 12 months the IWJ has published papers from the four corners of the globe ensuring its global reach and appropriateness to an international audience. China alone published six papers in this short time period, demonstrating the growing importance of this geographical region in our research and practice development.…”

mentioning

confidence: 99%