Progress in development of bioderived materials for dermal wound healing

Abstract

Treatment of acute and chronic wounds is one of the primary challenges faced by doctors. Bioderived materials have significant potential clinical value in tissue injury treatment and defect reconstruction. Various strategies, including drug loading, addition of metallic element(s), cross-linking and combining two or more distinct types of materials with complementary features, have been used to synthesize more suitable materials for wound healing. In this review, we describe the recent developments made in the processing of bioderived materials employed for cutaneous wound healing, including newly developed materials such as keratin and soy protein. The focus was on the key properties of the bioderived materials that have shown great promise in improving wound healing, restoration and reconstruction. With their good biocompatibility, nontoxic catabolites, microinflammation characteristics, as well as their ability to induce tissue regeneration and reparation, the bioderived materials have great potential for skin tissue repair.

Progress in developing decellularized bioscaffolds for enhancing skin construction

“…90 In addition, SIS scaffolds contain TGF-β, basic FGF, VEGF, and EGF, can promote angiogenesis, cell growth, and differentiation, thus promoting tissue regeneration. 91 OaSIS Wound Matrix (Cook Biotech Inc., West Lafayette, IN) is a trilayered natural matrix in which both surfaces are smooth, without openings or pores. This material is processed by decellularization and retains multiple components found in human normal dermis, including collagens (types I, III, IV, and VI), elastin, heparin, hyaluronic acid, chondroitin, laminin, and decorin.…”

Future Research Directions in the Design of Versatile Extracellular Matrix in Tissue Engineering

“…In the fabrication of a native ECM from cell- and tissue-derived ECMs, decellularization is an important process for removing cells from the scaffold without disturbing the chemical complexity and the mechanical structure of the matrix, including its microstructure and stiffness. Decellularized ECM scaffolds have broad applications in tissue engineering, wound healing, and disease modeling [ 9 , 16 , 18 , 37 - 40 ]. The characteristics of those decellularized ECM scaffolds, such as their good biocompatibility, nontoxic catabolites, and microinflammatory characteristics, as well as their regenerative ability, hold great potential for tissue engineering and wound healing [ 40 ].…”

“…Decellularized ECM scaffolds have broad applications in tissue engineering, wound healing, and disease modeling [ 9 , 16 , 18 , 37 - 40 ]. The characteristics of those decellularized ECM scaffolds, such as their good biocompatibility, nontoxic catabolites, and microinflammatory characteristics, as well as their regenerative ability, hold great potential for tissue engineering and wound healing [ 40 ]. The decellularization of sterilized porcine bladder and urologic ECM as a material for bladder scaffolding and lower urinary tract reconstruction has shown promising results [ 41 ].…”

Wound Healing Potentials of some Fin Fishes

“…The human skin protects the tissues and organs from physical, mechanical, chemical and microbial damage and they mainly consist of the epidermis, dermis and subcutaneous tissue (Da et al, 2017;Bi and Jin, 2013). Skin injury often cause disruption of neutrophils, monocytes and macrophages on the site of injury (Barrientos et al, 2008;Akunne et al, 2016).Wound infection is one of the health concerns that are caused and aggravated by the invasion of pathogenic microorganisms (Mama et al, 2014).…”

“…Furthermore, Obi (2015) classified wound into accidental, pathological or post-operative. Da et al (2017), Patrulea et al (2015) also classified wound based on its thickness including superficial, partial-thickness and fullthickness.…”