Influence of hepatitis G virus infection on liver disease

Diamantis, Ioannis; Koulentaki, Mairi; Fasler‐Kan, Elizaveta; Schmid, Peter; Hirsch, Hans H.; Bühler, H; Gyr, K.; Battegay, Manuel

doi:10.1007/bf01700559

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…Finally, a trend was noted toward more severe fibrosis in patients with dual infection. Similarly, Diamantis et al [1997] reported previously that virus load and ALT levels did not differ significantly in patients coinfected with HCV and GBV-C/HGV. However, mild fibrosis correlated with GBV-C/HGV coinfection.…”

supporting

confidence: 67%

Clinical implications of GB virus C

Mushahwar

Zuckerman

1998

J. Med. Virol.

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supporting

confidence: 67%

Clinical implications of GB virus C

Mushahwar

Zuckerman

1998

J. Med. Virol.

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“…The authors suggested that GBV-C/HGV in patients with HCV infection might accelerate liver injury toward more severe fibrosis in patients with dual infection. Diamantis et al (Diamantis et al 1997) reported that mild fibrosis correlated with GBV-C/HGV whilst Francesconi et al (Francesconi et al 1997) observed subtleties in histological appearance in HCV co-infected patients. However, numerous studies have shown that in HCV co-infected individuals, GBV-C/HGV does not affect HCV replication, HCV RNA concentration, and liver disease Bralet et al 1997;Enomoto et al 1998;Pawlotsky et al 1998;Petrik et al 1998;Slimane et al 2000).…”

Section: Current Status Reviewmentioning

confidence: 99%

“…Diamantis et al . (Diamantis et al . 1997) reported that mild fibrosis correlated with GBV‐C/HGV whilst Francesconi et al .…”

Section: Detection Of Gbv‐c/hgvmentioning

confidence: 99%

GB Virus C/Hepatitis G Virus (GBV‐C/HGV): still looking for a disease

Sathar

Soni²,

York

2000

Int J Experimental Path

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GB Virus C and Hepatitis G Virus (GBV-C/HGV) are positive, single-stranded flaviviruses. GBV-C and HGV are independent isolates of the same virus. Transmission via the blood-borne route is the commonest mode, although vertical and sexual transmission is well documented. GBV-C/HGV is distributed globally; its prevalence in the general population is 10 fold higher in African countries than in non-African countries. High prevalences of GBV-C/HGV have been found in subjects with frequent parenteral exposure and in groups at high risk of exposure to blood and blood products. The clinical significance of human infection with GBV-C/HGV is currently unclear. The virus can establish both acute and chronic infection and appears to be sensitive to interferon. Only some 12-15% of chronic Non-A, B, C hepatitis cases are infected with GBV-C/HGV. A direct association with liver pathology is still lacking and it is not yet clear as to whether GBV-C/HGV is indeed a hepatotropic virus. Current evidence suggests that the spectrum of association of GBV-C/HGV infection with extrahepatic diseases ranges from haematalogical diseases, aplastic anaemia, human immunodeficiency virus (HIV)-positive idiopathic thrombocytopenia and thalassemia, through to common variable immune deficiency and cryoglobunemia.

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GB virus C

Leary

Mushahwar

2003

Perspectives in Medical Virology

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Influence of hepatitis G virus infection on liver disease

Cited by 6 publications

References 14 publications

Clinical implications of GB virus C

Clinical implications of GB virus C

GB Virus C/Hepatitis G Virus (GBV‐C/HGV): still looking for a disease

GB virus C

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