Abstract:The properties of sodium hyaluronate (HA), such as hygroscopicity, flexibility, the ability to form hydrogels, as well as biocompatibility and biodegradability, are beneficial for the applications in pharmaceutical technology, cosmetics industry, and aesthetic medicine. The aim of this study was to prepare HA-based hydrogels doped with active pharmaceutical ingredient (API): a cationic drug—lidocaine hydrochloride or anionic drug—sodium. The interaction between the carrier and the implemented active pharmaceut… Show more
“…Notably, the HA-HS conditions exhibited higher moisture retention percentages compared to HA-DI across all HA concentration ranges from 0.5% to 3%. The hygroscopic properties of HA [37] enable it to attract and retain water molecules from the surrounding environment effectively, thus hydrating the skin by drawing moisture from the air and deeper layers of the skin. Additionally, HA plays a role in supporting the skin's natural barrier function by maintaining adequate moisture levels in the outermost layer of the skin [38].…”
Section: Incorporation Of Hs Water In Combination With Ha As a Moistu...mentioning
Hot spring (HS) waters manifest diverse positive effects on the skin due to their unique chemical compositions. Sodium hyaluronate acid (HA) comprises N-acetylglucosamine and D-glucuronic acid, and distinguishes itself with superior qualities in skin regeneration, providing moisturizing and anti-aging benefits. The combination of HA with HS water is widely applied across ophthalmology, pneumology, nutrition, and cosmetics. This study delved into the application of HA in cosmetology, with a focus on its interaction with HS water and its effects on moisture retention and promoting wound healing. In particular, with the alkaline pH levels of the Yumoto HS, HA molecules may undergo dissociation to be ionized resulting in a negatively charged polymer and interacting with positively charged ions in the HS water through electrostatic interactions. The shifted peaks in the FTIR result and zeta potential shifts to a less negative region in the case of HA-HS compared to HA-DI indicate an ionic interaction between HS water and HA. Moisture tests confirmed the sustained hydration when HA is dissolved in HS water, underscoring its potential to improve skin hydration at certain concentrations, specifically at 0.5% and 1%. Additionally, MTT assay results demonstrated that HS water stimulates the growth of fibroblast cells compared to distilled water, implying its potential beneficial effect in wound healing. These findings suggested the multifaceted benefits of HAHS in skincare, highlighting its role in enhancing skin hydration and potentially accelerating wound healing processes, thus presenting avenues for the development of advanced cosmeceutical formulations.
“…Notably, the HA-HS conditions exhibited higher moisture retention percentages compared to HA-DI across all HA concentration ranges from 0.5% to 3%. The hygroscopic properties of HA [37] enable it to attract and retain water molecules from the surrounding environment effectively, thus hydrating the skin by drawing moisture from the air and deeper layers of the skin. Additionally, HA plays a role in supporting the skin's natural barrier function by maintaining adequate moisture levels in the outermost layer of the skin [38].…”
Section: Incorporation Of Hs Water In Combination With Ha As a Moistu...mentioning
Hot spring (HS) waters manifest diverse positive effects on the skin due to their unique chemical compositions. Sodium hyaluronate acid (HA) comprises N-acetylglucosamine and D-glucuronic acid, and distinguishes itself with superior qualities in skin regeneration, providing moisturizing and anti-aging benefits. The combination of HA with HS water is widely applied across ophthalmology, pneumology, nutrition, and cosmetics. This study delved into the application of HA in cosmetology, with a focus on its interaction with HS water and its effects on moisture retention and promoting wound healing. In particular, with the alkaline pH levels of the Yumoto HS, HA molecules may undergo dissociation to be ionized resulting in a negatively charged polymer and interacting with positively charged ions in the HS water through electrostatic interactions. The shifted peaks in the FTIR result and zeta potential shifts to a less negative region in the case of HA-HS compared to HA-DI indicate an ionic interaction between HS water and HA. Moisture tests confirmed the sustained hydration when HA is dissolved in HS water, underscoring its potential to improve skin hydration at certain concentrations, specifically at 0.5% and 1%. Additionally, MTT assay results demonstrated that HS water stimulates the growth of fibroblast cells compared to distilled water, implying its potential beneficial effect in wound healing. These findings suggested the multifaceted benefits of HAHS in skincare, highlighting its role in enhancing skin hydration and potentially accelerating wound healing processes, thus presenting avenues for the development of advanced cosmeceutical formulations.
“…The kinetic analysis was carried out using zero-, first-, and second-order kinetics as well as Higuchi and Korsmeyer-Peppas dependences [31][32][33][34]. The equations were included in our previous work [23,35,36], and they are as follows:…”
Section: Kinetic Studymentioning
confidence: 99%
“…The measured viscosity of the formulations F1-F3 containing Nap and Lid, in comparison to the viscosity of the corresponding Lid-free hydrogels assessed in previous work [23], is listed in Table 2. It was found that the viscosity of the preparations F1-F3 was lower than the corresponding viscosity of hydrogels with Nap only.…”
Section: Viscosity Studymentioning
confidence: 99%
“…This work was a continuation of previous studies concerning the influence of the HA on the dissolution patterns of anionic and cationic drug introduced into the hydrogel. The anionic drug was sodium naproxen (Nap) and the cationic substance was lidocaine hydrochloride (Lid) [23]. In the present work, we studied the release of Nap from HA-based matrixes in the presence of Lid.…”
Section: Introductionmentioning
confidence: 99%
“…The purpose of this work was to test the Lid's influence on the dissolution of Nap from HA-based hydrogels. It was interesting to calculate the kinetic parameters of Nap release from formulations containing Lid and to compare the parameters with the values obtained in the previous study, where Nap was released from hydrogels without Lid [23]. Moreover, the interactions between the ingredients of the composition were also studied.…”
Sodium hyaluronate (HA) is a natural polysaccharide. This biopolymer occurs in many tissues of living organisms. The regenerating, nourishing, and moisturizing properties as well as the rheological properties of HA enable its application in the pharmaceutical industry as a carrier of medicinal substances. The aim of this work was to assess the release of naproxen sodium (Nap) in the presence of lidocaine hydrochloride (Lid) from the biopolymer-based hydrogels and to determine the respective kinetic parameters of this process. The possible interaction between the HA polysaccharide carrier and the selected drugs was also investigated. Three hydrogels containing Nap and Lid with different concentrations of the biopolymer were prepared. The release of Nap was studied by employing USP apparatus 5. The infrared study and differential scanning calorimetry analysis of physical mixtures and dried formulations were performed. The highest amount of Nap was released from the formulation with the lowest concentration of the biopolymer. The most representative kinetic model that described the dissolution of Nap was obtained through the Korsmeyer–Peppas equation. The release rate constants were in the range of 1.0 ± 0.1 × 10−2 min−n–1.7 ± 0.1 × 10−2 min−n. Lid did not influence the dissolution of Nap from the formulations tested; however, in the desiccated samples of assessed formulations, the interaction between the polysaccharide and both drugs was observed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.