Cancer is a hyper-proliferative disorder, which involves transformation, deregulation of apoptosis, proliferation, invasion, angiogenesis, and metastasis. Worldwide, more than half a million people died of cancer every year, at a rate of 1500 patients every day [1]. Breast cancer is the second leading cancer in women, accounting for 25 % of all cases [2]. Currently tamoxifen, selective oestrogen receptor modulator, is widely used in the prevention and treatment of oestrogen receptor positive breast cancer [3]. However, a significant number of patients develop tamoxifen resistance and experience severe side effects [4,5]. It is therefore, imperative to search for newer compounds, which are effective, greener and not with many side effects. As the conventional cancer therapies failed to fulfil the criteria for successful cancer treatments, recent research revolved around the urgency to develop suitable therapy for the cure of cancer with no toxic effects through methodical and scientific exploration of the enormous pool of synthetic, biological, and natural products [2,6-9]. Plant-derived natural products received significant attention due to their diverse pharmacological properties and cancer preventive effects. With the presence of flavonoids, alkaloids and terpenes, these offer different forms of cytotoxic effects such as cell proliferation inhibition, apoptosis induction or modulating signal transduction, without exhibiting considerable damage to normal cells [7-13]. These are relatively new, but very promising strategies in preventing cancer due to both additive and synergistic effects [8]. Interest in the pharmacological effects of bioactive compounds on cancer treatments and prevention has increased dramatically over the past 20 y. Many fruits such as guava [13] , banana [11] , papaya [12] , lemon [14] , orange [15] , apple, water melon, litchi are reported to possess proven medicinal activities when