Influence of glycosylated hemoglobin on the choroidal thickness

Şahinoğlu-Keşkek, Nedime; Altan-Yaycıoğlu, Rana; Canan, Handan; Çoban-Karataş, Müge

doi:10.1007/s10792-017-0668-2

Cited by 11 publications

(10 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with other studies, DM duration had no significant correlations with CT(s) and CV(s) in our series [ 15 , 22 , 32 ]. According to our findings, FBS had no association with CT or CV.…”

Section: Discussionsupporting

confidence: 93%

The quantitative measurements of choroidal thickness and volume in diabetic retinopathy using optical coherence tomography and optical coherence tomography angiography; correlation with vision and foveal avascular zone

et al. 2022

View full text Add to dashboard Cite

Background To represent choroidal thickness (CT) and choroidal volume (CV) databases in diabetic retinopathy (DR) patients and healthy control participants using optical coherence tomography (OCT) and enhanced depth imaging OCT (EDI-OCT). No study had evaluated CT at all main stages of diabetic retinopathy in a single study. Methods The study included 176 eyes from 93 patients (39–80 years old; 42% females) who were divided into three groups based on DR severity and normal control group: 39 eyes no DR, 64 eyes NPDR, 33 eyes PDR, and 40 eyes normal control. The CT and CV were measured and statistically analyzed. Intra-observer and inter-observer coefficients of repeatability were calculated. Results Subfoveal CT showed persistent thinning from normal group (322.50 ± 69.24) to no-diabetic retinopathy (NDR, 308.33 ± 74.45) to nonproliferative diabetic retinopathy (NPDR, 283.45 ± 56.50) group and then thickening as the patient progressed to proliferative diabetic retinopathy (PDR, 295.17 ± 95.69) (P = 0.087). A significant difference was found between the control group and the NDR, NPDR, and PDR groups in nearly all CT and CV of Early Treatment Diabetic Retinopathy Study macular subfields. Fasting blood sugar (FBS = 189.08 ± 51.3 mg/dl) and diabetes mellitus (DM) duration (13.6 ± 6.5 years) had no noticeable effect on CT. In patients with diabetes, the best-corrected visual acuity (BCVA), diabetic macular edema (DME), and foveal avascular zone (FAZ) were not affected by CT and CV. Conclusions The choroidal thickness decreases from the early stages of diabetic retinopathy up to the NPDR stage, with a subsequent modest rise in CT during the PDR stage. There was no correlation between FBS, diabetes duration, BCVA, DME, and FAZ, and CT.

show abstract

Section: Discussionsupporting

confidence: 93%

The quantitative measurements of choroidal thickness and volume in diabetic retinopathy using optical coherence tomography and optical coherence tomography angiography; correlation with vision and foveal avascular zone

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In the current study, we found that there was no significant correlation between the duration of diabetes and choroidal thickness. This is compatible with the studies of Sahinoghlu-Keskek et al and Shen et al [23,26]…”

Section: Discussionsupporting

confidence: 93%

“…Sahinoglu-Keskek et al classified 122 eyes of 122 diabetic patients into three study groups including diabetic patients without DR, diabetic patients with DR and no macular edema, and diabetic patients with DR and macular edema. [23] They reported that the sub-foveal choroid in patients with no DR was significantly thicker than that in patients with DR and without macular edema. Moreover, they reported that no significant differences in HbA1c levels were detected among the three study groups and concluded that there was no correlation between sub-foveal choroidal thickness and HbA1c values.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness and Hemoglobin A1c Levels in Patients with Type 2 Diabetes Mellitus

Torabi

Isfeedvajani

Ramezani

et al. 2019

JOVR

View full text Add to dashboard Cite

PurposeThe aim of this study was to assess the correlation of hemoglobin A1c (HbA1c) levels with choroidal thickness in patients with type 2 diabetes mellitus (DM) using spectral domain optical coherence tomography (SD-OCT).MethodsIn this prospective case series, 180 eyes from 90 patients with type 2 DM were classified into three study groups based on HbA1c values: group 1 included patients with good glycemic control (HbA1c ≤ 7%), group 2 included patients with moderate glycemic control (HbA1c between 7% and 8%), and group 3 included patients with poor glycemic control (HbA1c ≥ 8%). Additionally, 50 eyes from 25 non-diabetic subjects were enrolled to group 4 as a control group. Sub-foveal, nasal, and temporal choroidal thickness were measured and compared.ResultsMean central, nasal, and temporal choroidal thicknesses in diabetic patients (247.80, 238.63, and 239.30 μm) were significantly less than non-diabetic healthy subjects (277.56, 262.92, and 266.32 μm). Additionally, mean central, nasal, and temporal choroidal thickness values in group 4 (277.56, 262.92, and 266.32 μm) were significantly greater than the corresponding values in group 2 (248.34, 237.55, and 236.45 μm) and group 3 (239.81, 234.62, and 233.94 μm), but was not significantly different from corresponding values in group 1 (259.46, 246.12, and 251.00 μm).Conclusion HbA1c values have a significant correlation with choroidal thickness in diabetic patients, and better glycemic control with HbA1c ≤ 7% may prevent choroidal thinning.

show abstract

“…The Beijing Eye Study reported that the glucose level did not affect subfoveal CT, but HbA1c was not determined in that study. Sahinoglu-Keskek et al 31 found no correlation between HbA1c and subfoveal CT. Our study confirmed that macular CT was not independently associated with HbA1c. Jonas et al 32 reported that subfoveal CT was significantly associated with BCVA after adjusting for age, sex, AL, and corneal curvature in the normal population.…”

Section: Discussionmentioning

confidence: 95%

Choroidal Thickness in Diabetes and Diabetic Retinopathy: A Swept Source OCT Study

Wang

Liu

Qiu

et al. 2020

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Previous studies on the association between choroidal thickness (CT) and severity of diabetic retinopathy (DR) gave conflicting results. The aim of this study was to evaluate the CT changes in diabetic patients and associated factors in a large sample of Chinese patients with diabetes. METHODS. Type 2 diabetes mellitus patients without history of ocular treatment were recruited from the community health system in Guangzhou, China. The swept source OCT instrument was used to obtain high-definition retina and choroid images. The diabetic retinopathy (DR) status was graded based on the guidelines of the United Kingdom National Diabetic Eye Screening Programme. Univariate and multivariate linear regression analyses was used to explore the association of CT with DR severity, diabetic macular edema (DME), hemoglobin A1c, and vision function. RESULTS. A total of 1347 patients were included in the final analysis. After adjusting for other factors, the patients with stage R3 DR had significantly thinner CT (β =-29.1 μm, 95% CI-53.8 to-4.4, P = 0.021) in comparison in those with R0. After adjusting for other factors, the CTs were thicker than those in R0 patients with difference of 15.6 μm (95% CI 4.3-26.9, P = 0.007) for outer nasal sector, 15.7 μm (95% CI 3.8-25.5, P = 0.008) for outer inferior, and 12.2 μm (95% CI 0.4-24.0, P = 0.042) for inner inferior sector. The presence of DME and hemoglobin A1c levels did not significantly affect average CT. Higher average CT was significantly associated with better best corrected visual acuity, with a-0.02 LogMAR unit per 100 μm increase in average CT (95% CI-0.03 to-0.01, P < 0.001). CONCLUSIONS. CT increased in the early stage of DR, and further decreased with DR progression. DME was not significantly associated with CT. These findings provide more clues to suggest that choroid alterations play a role in the pathogenesis of DR.

show abstract

Influence of glycosylated hemoglobin on the choroidal thickness

Abstract: Serum HbA1c levels were not correlated with foveal choroidal thickness. Choroidal thickness is effected by several factors as axial length, age and systemic diseases.

Cited by 11 publications

References 21 publications

The quantitative measurements of choroidal thickness and volume in diabetic retinopathy using optical coherence tomography and optical coherence tomography angiography; correlation with vision and foveal avascular zone

The quantitative measurements of choroidal thickness and volume in diabetic retinopathy using optical coherence tomography and optical coherence tomography angiography; correlation with vision and foveal avascular zone

Choroidal Thickness and Hemoglobin A1c Levels in Patients with Type 2 Diabetes Mellitus

Choroidal Thickness in Diabetes and Diabetic Retinopathy: A Swept Source OCT Study

Contact Info

Product

Resources

About