Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1

Mitrović, Milena; Ilić, Tamara; Stokić, Edita; Novakovic-Paro, Jovanka; Tomic-Naglic, Dragana; Bajkin, Ivana; Ičin, Tijana

doi:10.2298/vsp1109756m

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…78 In the general population, CRP is considered a marker for future chronic disease and, in obese individuals, its levels are positively correlated with BMI. 69,79 Leptin and adiponectin secretion are related with circulating CRP levels.…”

Section: C-reactive Proteinmentioning

confidence: 99%

Maternal obesity and inflammatory mediators: A controversial association

Pendeloski

Ono

Torloni

et al. 2017

American J Rep Immunol

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The link between maternal obesity and inflammatory mediators is still unclear. Our aim was to summarize the main findings of recently published studies on this topic. We performed a search in Medline for studies published in the last years on obesity, human pregnancy, and inflammatory mediators. We report the findings of 30 studies.The characteristics and number of participants, study design, gestational age at sample collection, and type of sample varied widely. Approximately two-thirds of them investigated more than one mediator, and 50% included participants in only one trimester of pregnancy. The most frequently investigated mediators were leptin, tumour necrosis factor-alpha (TNF-α), and interleukin (IL)-6. Almost all studies reported an association between maternal obesity, leptin, and C-reactive protein (CRP) serum levels but not with IL-1β and IL-10. The association of IL-6, TNF-α, monocyte chemo-attractant protein-1 (MCP-1), adiponectin, and resistin with maternal obesity is still controversial.To clarify the physiopathological link between maternal obesity and inflammation, more high-quality studies are needed. K E Y W O R D Sadipokine, cytokine, inflammatory mediator, maternal obesity, pregnancy | INTRODUCTIONObesity has more than doubled in the last decades in the general population. Maternal obesity is also increasing. In the United Kingdom, nearly 20% of pregnant women are obese, 1 and in the United States, over 50% of all pregnant women are currently overweight or obese.2 Obesity in pregnancy is associated with both immediate and long term adverse events for both the mother and the offspring, including the risk of metabolic diseases years after delivery.

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Section: C-reactive Proteinmentioning

confidence: 99%

Maternal obesity and inflammatory mediators: A controversial association

Pendeloski

Ono

Torloni

et al. 2017

American J Rep Immunol

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“…Even in semen TNF-α levels are higher in smokers (24). In addition, C-reactive protein, a major inflammatory marker, is increased at a higher age, and among smokers (25). One study found higher soluble TNF receptors (sTNFR) in the serum of smokers, although increased serum TNF-α levels were not found (26).…”

mentioning

confidence: 99%

Smoking does not Alter the Therapy Response to Systemic Anti-psoriatic Therapies: A Two-country, Multi-centre, Prospective, Non-interventional Study

et al. 2019

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The German (PsoBest) and Swiss (SDNTT) Psoriasis Registries collect data on the efficacy of anti-psoriatic treatments among smokers and non-smokers. Out of 5,346 patients included in these registries, 1,264 met the inclusion criteria for this study. In the smoking group, 715 (60.6%) reached therapy response at month 3, compared with 358 (63.7%) in the non-smoking group. At month 6, 659 (74.1%) vs. 330 (77%), and at month 12, 504 (76.6%) vs. 272 (79.0%) reached therapy response. Therefore, these data do not show that smoking affects the response rate of anti-psoriatic therapy after 3, 6 and 12 months. Psoriasis can involve the skin, joints, nails and cardiovascular system and result in a significant impairment in quality of life. Studies have shown a lower response rate to systemic anti-sporiatic therapies in smokers, and smoking is a trigger factor for psoriasis. The aim of this study was therefore to analyse the response to systemic therapies for psoriasis, with a focus on smoking. Prospectively collected data from patients with moderate to severe psoriasis included in the national psoriasis registries for Germany and Switzerland (Pso-Best and SDNTT) were analysed. Therapy response was defined as reaching a Psoriasis Area and Severity Index (PASI) reduction of 75%, PASI ≤ 3 or Dermatology Life Quality Index (DLQI) ≤ 1. Out of 5,346 patients included in these registries, 1,264 met the inclusion criteria for this study. In the smoking group, 715 (60.6%) reached therapy response at month 3, compared with 358 (63.7%) in the non-smoking group (p ≤ 0.269), 659 (74.1%) vs. 330 (77%) reached therapy response at month 6 (p ≤ 0.097), and 504 (76.6%) vs. 272 (79.0%) at month 12 (p ≤ 0.611). Therefore, these data do not show that smoking affects the response rate of anti-psoriatic therapy after 3, 6 and 12 months.

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“…Some of the trials dealing with serum levels of TNF-α in T1DM report that they are higher in patients than in nondiabetic individuals [109,110], while other investigators have determined comparable levels in these two groups [111]. Serum TNF-α level was found to be associated with the fifteen year cumulative incidence of gross proteinuria in patients with T1DM [112], while other study has not found the difference in TNF-α serum levels in T1DM patients without and with developed DN [104].…”

Section: Tumor Necrosis Factor-α and Chronic Complications Of Type 1 Diabetesmentioning

confidence: 93%

Levels of different adipocytokines in chronic complications of type 1 diabetes mellitus

Popovic¹,

Sekeruš²

2016

Integr Obesity Diabetes

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Influence of glucoregulation quality on c-reactive protein, interleukin-6 and tumor necrosis factor-α level in patients with diabetes type 1

Abstract: The patients with type 1 diabetes were found to have a low level of inflammatory activity manifested by the increased values of CRP, IL-6 and TNF-alpha.

Cited by 5 publications

References 30 publications

Maternal obesity and inflammatory mediators: A controversial association

Maternal obesity and inflammatory mediators: A controversial association

Smoking does not Alter the Therapy Response to Systemic Anti-psoriatic Therapies: A Two-country, Multi-centre, Prospective, Non-interventional Study

Levels of different adipocytokines in chronic complications of type 1 diabetes mellitus

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